| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Lipids are important biological substances that are involved in signaling roles and energy storages. Among them triacylglycerol (TG) is a major component of food and animal fats. Excess amount of TG storages induce metabolic diseases such as type 2 diabetes and coronary heart disease. Because visceral TG significantly affects human health, we analyzed TG in fatty liver.
TG species in fatty liver can be detected by imaging mass spectrometry (IMS) and the results provided a reliable distribution map of the TG peaks. Compared with histological analyses, IMS provided better semi-quantitative visualisation of preferred TG peaks in liver specimens and would thus serve as a useful tool for clinical and other estimations of fatty liver. Analysis using MS/MS showed a structural change between liver TG and dietary TG. These findings suggest that MALDI-SpiralTOF is a powerful tool for clinical screening and estimating fatty liver, and that resveratrol improves fatty liver.
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