Cancer Microenvironment formed by peritoneal invasion enhance tumor progression through the activation of subperitoneal fibroblast.
| Project/Area Number |
24590458
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
MOTOHIRO Kojima 独立行政法人国立がん研究センター, その他部局等, その他 (30338470)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 人体病理学 / 大腸がん / 癌微小環境 / 大腸癌 / 癌 / 漿膜浸潤 / 病理学 / 線維芽細胞 |
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| Outline of Final Research Achievements |
We reported firstly that peritoneal elastic laminal invasion (ELI) in colon cancer is the strong prognostic factor. This report is going to get world-wide consensus, and upstaging of pT3 colon cancer with ELI is proposed. Furthermore, we found morphologically distinct tumor microenvironment was formed in tumor area with peritoneal invasion, and defined it as cancer microenvironment formed by peritoneal invasion (CMPI). We propagated subperitoneal fibroblast (SPF) from human peritoneum, and found that SPF is characterized by the robust gene overexpression by cancer medium stimulation. Using in vivo mouse model co-injected with subperitoneal fibroblast and cancer cells, we found that SPF actively promote tumor progression and metastasis. Together with these findings, SPF plays crucial role in cancer progression and metastasis in tumor area of CMPI.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] A resected case of intraductal tubulopapillary neoplasm of the pancreas: report of a case.2015
Author(s)
Kitaguchi K, Kato Y, Kojima M, Okubo S, Takahashi D, Okada R, Nakayama Y, Nishida Y, Gotohda N, Takahashi S, Konishi M.
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Journal Title
Int Surg
Volume: 100(2)
Issue: 2
Pages: 281-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Hypoxia imaging endoscopy equipped with laser light source from preclinical live animal study to first-in-human subject research.2014
Author(s)
Kaneko K, Yamaguchi H, Saito T, Yano T, Oono Y, Ikematsu H, Nomura S, Sato A, Kojima M, Esumi H, Ochiai A.
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Journal Title
PLoS One
Volume: 9(6)
Issue: 6
Pages: e99055-e99055
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic impact of M2 macrophages at neural invasion in patients with invasive ductal carcinoma of the pancreas.2014
Author(s)
Sugimoto M, Mitsunaga S, Yoshikawa K, Kato Y, Gotohda N, Takahashi S, Konishi M, Ikeda M, Kojima M, Ochiai A, Kaneko H.
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Journal Title
Eur J Cancer
Volume: 50(11)
Issue: 11
Pages: 1900-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Hypoxia imaging endoscopy equipped with laser light source from preclinical live animal study to first-in-human subject research.2014
Author(s)
Kaneko K, Yamaguchi H, Saito T, Yano T, Oono Y, Ikematsu H, Nomura S, Sato A, Kojima M, Esumi H, Ochiai A.
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Journal Title
PLOS ONE
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Histogenesis and prognostic value of myenteric spread in colorectal cancer: a Japanese multi-institutional study.2014
Author(s)
Ueno H, Shirouzu K, Shimazaki H, Kawachi H, Eishi Y, Ajioka Y, Okuno K, Yamada K, Sato T, Kusumi T, Kushima R, Ikegami M, Kojima M, Ochiai A, Murata A, Akagi Y, Nakamura T, Sugihara K; Study Group for Perineural Invasion projected by the Japanese Society for Cancer of the Colon and Rectum (JSCCR).
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Journal Title
J Gastroenterol
Volume: 49
Issue: 3
Pages: 400-407
DOI
Related Report
Peer Reviewed
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[Journal Article] Practical utility and objectivity: does evaluation of peritoneal elastic laminal invasion in colorectal cancer overcome these contrary problems?2014
Author(s)
Kojima M, Shimazaki H, Iwaya K, Kage M, Akiba J, Ohkura Y, Horiguchi S, Shomori K, Kushima R, Ajioka Y, Nomura S, Ochiai A.
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Journal Title
Am J Surg Pathol
Volume: 38
Issue: 1
Pages: 144-145
DOI
Related Report
Peer Reviewed
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[Journal Article] Pathological diagnostic criterion of blood and lymphatic vessel invasion in colorectal cancer: a framework for developing an objective pathological diagnostic system using Delphi method, from the Pathology Working Group of the Japanese Society for Cancer of the Colon and Rectum.2013
Author(s)
Kojima M, Shimazaki H, Iwaya K, Kage M, Akiba J, Ohkura Y, Horiguchi S, Shomori K, Kushima R, Ajioka Y, Nomura S, Ochiai A.
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Journal Title
J Clin Pathol
Volume: 66
Issue: 7
Pages: 551-558
DOI
Related Report
Peer Reviewed
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[Journal Article] Characterization of perineural invasion as a component of colorectal cancer staging.2013
Author(s)
Ueno H, Shirouzu K, Eishi Y, Yamada K, Kusumi T, Kushima R, Ikegami M, Murata A, Okuno K, Sato T, Ajioka Y, Ochiai A, Shimazaki H, Nakamura T, Kawachi H, Kojima M, Akagi Y, Sugihara K; Study Group for Perineural Invasion projected by the Japanese Society for Cancer of the Colon and Rectum (JSCCR).
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Journal Title
Am J Surg Pathol
Volume: 37
Issue: 10
Pages: 1542-1549
DOI
Related Report
Peer Reviewed
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[Journal Article] Pathological diagnostic criterion of blood and lymphatic vessel invasion in colorectal cancer: a framework for developing an objective pathological diagnostic system using the Delphi method, from the Pathology Working Group of the Japanese Society for Cancer of the Colon and Rectum.2013
Author(s)
Kojima M, Shimazaki H, Iwaya K, Kage M, Akiba J, Ohkura Y, Horiguchi S, Shomori K, Kushima R, Ajioka Y, Nomura S, Ochiai A.
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Journal Title
J Clin Pathol.
Volume: 未定
Related Report
Peer Reviewed
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