| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We reported firstly that peritoneal elastic laminal invasion (ELI) in colon cancer is the strong prognostic factor. This report is going to get world-wide consensus, and upstaging of pT3 colon cancer with ELI is proposed. Furthermore, we found morphologically distinct tumor microenvironment was formed in tumor area with peritoneal invasion, and defined it as cancer microenvironment formed by peritoneal invasion (CMPI). We propagated subperitoneal fibroblast (SPF) from human peritoneum, and found that SPF is characterized by the robust gene overexpression by cancer medium stimulation. Using in vivo mouse model co-injected with subperitoneal fibroblast and cancer cells, we found that SPF actively promote tumor progression and metastasis. Together with these findings, SPF plays crucial role in cancer progression and metastasis in tumor area of CMPI.
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