Regulation of vascular smooth muscle phenotypes by lysophosphatidic acid receptor signaling

• Project/Area Number: 24590462
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kurume University (2014); University of the Ryukyus (2012-2013)
• Principal Investigator: KATO Seiya 久留米大学, 医学部, 非常勤講師 (60268844)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 血管平滑筋細胞 / 形質転換 / 動脈硬化 / リゾフォスファチジン酸

Outline of Final Research Achievements

Lysophosphatidic acid (LPA) is a promoting factor of various aspects of phenotypic modulation of vascular smooth muscle cells, which has been known to be synthesized in the atheromatous lesions from oxidized low-density lipoprotein. Present study may suggest that the expression levels of non-EDG (endothelial differentiation gene) family receptors (LPA4-6) are relatively larger than those of EDG family receptors (LPA1-3). At the down-stream of non-EDG family receptors, differential manner in the activation of transcriptional factors from EDG family receptor activations, may contribute to the regulation of vascular smooth muscle functions.

Research Products

• [Journal Article] Large Blood Pressure Variability Aggravates Arteriolosclerosis and Cortical Sclerotic Changes in the Kidney in Hypertensive Rats (2014)
  • Author(s): Aoki Y, Kai H, Kajimoto H, Kudo H, Takayama N, Yasuoka S, Anegawa T, Iwamoto Y, Uchiwa H, Fukuda K, Kage M, Kato S, Fukumoto Y, Imaizumi T.
  • Journal Title: Circulation Journal Volume: 78 Issue: 9 Pages: 2284-2291
  • DOI: 10.1253/circj.CJ-14-0027
  • NAID: 130004677614
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Impact of diabetes mellitus on myocardial lipid deposition: an autopsy study (2014)
  • Author(s): Takaya Nakanishi, Seiya Kato
  • Journal Title: Pathology-Research and Practice Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Type II interleukin-4 receptor-mediated anti-inflammatory response in Mm1 and J774.1 macrophages (2014)
  • Author(s): Lin Yanhui, Seiya Kato
  • Journal Title: Ryukyu medical Journal Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Lysophosphatidic acid receptor 4 signaling potentially modulates malignant behavior in human head and neck squamous cell carcinoma cells (2013)
  • Author(s): Matayoshi S, Chiba S, Lin Y, Arakaki K, Matsumoto H, Nakanishi T, Suzuki M, Kato S.
  • Journal Title: Int J Oncol Volume: 42 Issue: 5 Pages: 1560-1568
  • DOI: 10.3892/ijo.2013.1849
  • Peer Reviewed
• [Presentation] マクロファージ細胞株Mm1およびJ774.1におけるII型IL-4受容体を介した抗炎症作用について (2014)
  • Author(s): Lin YH, Kato S
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島国際会議場（広島県広島市）
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 受容体選択的IL-4変異体による血管壁細胞の形質転換と動脈硬化病変の制御 (2013)
  • Author(s): Yanhui Lin、千葉俊明、新垣和也、松本裕文、又吉 宣、仲西貴也、大島孝一、加藤誠也
  • Organizer: 日本病理学会総会
  • Place of Presentation: 札幌
• [Presentation] 喉頭扁平上皮癌細胞におけるリゾフォスファチジン酸受容体LPA4遺伝子導入の効果 (2013)
  • Author(s): 又吉 宣、千葉俊明、Lin Yanhui、新垣和也、仲西貴也、松本裕文、加藤誠也
  • Organizer: 日本病理学会総会
  • Place of Presentation: 札幌
• [Presentation] Ectopic wild type gene transfer successfully corrects vascular smooth muscle phenotypes of adipose tissue triglyceride lipase deficient mouse. (2012)
  • Author(s): Yanhui Lin, Shunmei Chiba, Akira Suzuki, Satoshi Yamaguchi, Takaya Nakanishi, Hirofumi Matsumoto, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Ken-ichi Hirano, Seiya Kato.
  • Organizer: American Heart Association, Scientific Sessions 2012
  • Place of Presentation: ロサンゼルス（米国）