Regulation of vascular smooth muscle phenotypes by lysophosphatidic acid receptor signaling
Project/Area Number |
24590462
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Kurume University (2014) University of the Ryukyus (2012-2013) |
Principal Investigator |
KATO Seiya 久留米大学, 医学部, 非常勤講師 (60268844)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 血管平滑筋細胞 / 形質転換 / 動脈硬化 / リゾフォスファチジン酸 |
Outline of Final Research Achievements |
Lysophosphatidic acid (LPA) is a promoting factor of various aspects of phenotypic modulation of vascular smooth muscle cells, which has been known to be synthesized in the atheromatous lesions from oxidized low-density lipoprotein. Present study may suggest that the expression levels of non-EDG (endothelial differentiation gene) family receptors (LPA4-6) are relatively larger than those of EDG family receptors (LPA1-3). At the down-stream of non-EDG family receptors, differential manner in the activation of transcriptional factors from EDG family receptor activations, may contribute to the regulation of vascular smooth muscle functions.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Large Blood Pressure Variability Aggravates Arteriolosclerosis and Cortical Sclerotic Changes in the Kidney in Hypertensive Rats2014
Author(s)
Aoki Y, Kai H, Kajimoto H, Kudo H, Takayama N, Yasuoka S, Anegawa T, Iwamoto Y, Uchiwa H, Fukuda K, Kage M, Kato S, Fukumoto Y, Imaizumi T.
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Journal Title
Circulation Journal
Volume: 78
Issue: 9
Pages: 2284-2291
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access
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[Presentation] Ectopic wild type gene transfer successfully corrects vascular smooth muscle phenotypes of adipose tissue triglyceride lipase deficient mouse.2012
Author(s)
Yanhui Lin, Shunmei Chiba, Akira Suzuki, Satoshi Yamaguchi, Takaya Nakanishi, Hirofumi Matsumoto, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Ken-ichi Hirano, Seiya Kato.
Organizer
American Heart Association, Scientific Sessions 2012
Place of Presentation
ロサンゼルス(米国)
Related Report