| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
This research aims to investigate and elucidate the immune system transcription network, mainly the newly discovered immune-related transcription regulatory factor, ZFAT (zinc-finger gene in AITD susceptibility region), and to understand the molecular mechanism of ZFAT in the development of immunological diseases. We have reported that Zfat is required for proper regulation of the TCR-proximal signalings, and is a crucial molecule for positive selection through ERK and Egr activities. Furthermore, we have demonstrated that Zfat critically participates in the development of DP thymocytes through regulating the activities of p38 and JNK.
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