Elucidation of the transcription factor Zfat function in the immune system using a conditional knockout mouse model
| Project/Area Number |
24590465
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Fukuoka University |
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Principal Investigator |
DOI Keiko 福岡大学, 医学部, 講師 (10341538)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIRASAWA Senji 福岡大学, 大学院医学研究科, 教授 (10253535)
TSUNODA Toshiyuki 福岡大学, 大学院医学研究科, 准教授 (70444817)
KOYANAGI Midori 福岡大学, 大学院医学研究科, 講師 (20153687)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ZFAT / T細胞 |
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| Outline of Final Research Achievements |
This research aims to investigate and elucidate the immune system transcription network, mainly the newly discovered immune-related transcription regulatory factor, ZFAT (zinc-finger gene in AITD susceptibility region), and to understand the molecular mechanism of ZFAT in the development of immunological diseases. We have reported that Zfat is required for proper regulation of the TCR-proximal signalings, and is a crucial molecule for positive selection through ERK and Egr activities. Furthermore, we have demonstrated that Zfat critically participates in the development of DP thymocytes through regulating the activities of p38 and JNK.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.2013
Author(s)
Ogawa M, Okamura T, Ishikura S, Doi K, Matsuzaki H, Tanaka Y, Ota T, Hayakawa K, Suzuki H, Tsunoda T, Sasazuki T, Shirasawa S.
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Journal Title
DOI
Related Report
Peer Reviewed
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