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Elucidation of the transcription factor Zfat function in the immune system using a conditional knockout mouse model

Research Project

Project/Area Number 24590465
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental pathology
Research InstitutionFukuoka University

Principal Investigator

DOI Keiko  福岡大学, 医学部, 講師 (10341538)

Co-Investigator(Renkei-kenkyūsha) SHIRASAWA Senji  福岡大学, 大学院医学研究科, 教授 (10253535)
TSUNODA Toshiyuki  福岡大学, 大学院医学研究科, 准教授 (70444817)
KOYANAGI Midori  福岡大学, 大学院医学研究科, 講師 (20153687)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsZFAT / T細胞
Outline of Final Research Achievements

This research aims to investigate and elucidate the immune system transcription network, mainly the newly discovered immune-related transcription regulatory factor, ZFAT (zinc-finger gene in AITD susceptibility region), and to understand the molecular mechanism of ZFAT in the development of immunological diseases. We have reported that Zfat is required for proper regulation of the TCR-proximal signalings, and is a crucial molecule for positive selection through ERK and Egr activities. Furthermore, we have demonstrated that Zfat critically participates in the development of DP thymocytes through regulating the activities of p38 and JNK.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

Research Products

(9 results)

All 2015 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (3 results)

  • [Journal Article] Zfat-deficient CD4⁺ CD8⁺ double-positive thymocytes are susceptible to apoptosis with deregulated activation of p38 and JNK.2015

    • Author(s)
      Ishikura S, Ogawa M, Doi K, Matsuzaki H, Iwaihara Y, Tanaka Y, Tsunoda T, Hideshima H, Okamura T, Shirasawa S.
    • Journal Title

      J Cell Biochem.

      Volume: 16(1) Pages: 149-157

    • DOI

      10.1002/jcb.24954

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The roles of ZFAT in thymocyte differentiation and homeostasis of peripheral naive T-cells.2014

    • Author(s)
      Doi K, Ishikura S, Shirasawa S.
    • Journal Title

      Anticancer Res

      Volume: 34 Pages: 4489-4495

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.2013

    • Author(s)
      Ogawa M, Okamura T, Ishikura S, Doi K, Matsuzaki H, Tanaka Y, Ota T, Hayakawa K, Suzuki H, Tsunoda T, Sasazuki T, Shirasawa S.
    • Journal Title

      PLoS One.

      Volume: 8

    • DOI

      10.1371/journal.pone.0076254

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response.2012

    • Author(s)
      Doi K, Shirasawa S
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 425(1) Pages: 107-112

    • DOI

      10.1016/j.bbrc.2012.07.065

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tespa1 is a novel IP3R-binding protein in T- and B-lymphocytes2012

    • Author(s)
      Matsuzaki H, Shirasawa S
    • Journal Title

      FEBS Open Bio.

      Volume: 2 Pages: 255-259

    • DOI

      10.1016/j.fob.2012.08.005

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model.2012

    • Author(s)
      Tsunoda T.
    • Journal Title

      Mol Cancer.

      Volume: 11(1) Pages: 11-46

    • DOI

      10.1186/1476-4598-11-46

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ZFAT欠損CD4+CD8+ double positive胸腺細胞におけるアポトーシス感受性の亢進2014

    • Author(s)
      土井佳子、石倉周平、岡村匡史、角田俊之、田中陽子、白澤専二
    • Organizer
      日本人類遺伝学会第59回大会
    • Place of Presentation
      船堀
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転写制御分子ZFAT欠損による胸腺内T細胞分化異常に関するZFAT分子機序の解明2013

    • Author(s)
      土井佳子、小川雅弘、岡村匡史、石倉周平、角田俊之、田中陽子、白澤専二
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] 遺伝子改変マウスを利用した転写制御分子ZFATの機能解明2012

    • Author(s)
      土井佳子
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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