| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The aims of this study were to focus on and analyze the hematopoietic regulatory system on the basis of three aspects, specifically focusing on a system that maintains hematopoietic stemness via hematopoietic stem/progenitor cell (HSPC) niches, the site of xenobiotic interrelationship. The first aim was to analyze the system during the dormancy period of HSPCs using several gene-modified mice with impaired hematopoiesis. The second aim was to examine the cellular and molecular mechanisms related to hematopoietic kinetic changes under oxidative stresses (e.g. induced by whole-body irradiation or benzene treatment). The third aim was to examine changes in the cell-cycle fraction during the senescent stage solely in relation to natural aging or in the presence of additional oxidative stresses such as those mentioned above. As a result, a functionally different regulatory/protecting systems were supposed to be present depending on the differentiation status of HSPCs.
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