Regulation of hematopoietic stem/progenitor cell (HSPC) cycle via HSPC niches, the site of xenobiotic interrelationship, in relation to natural aging
| Project/Area Number |
24590467
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
HIRABAYASHI Yoko 国立医薬品食品衛生研究所, 安全性生物試験研究センター毒性部, 室長 (30291115)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 造血幹・前駆細胞 / 幹細胞ニッチ / 生体異物相互作用 / 細胞周期 / 酸化ストレス / 酸化的ストレス |
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| Outline of Final Research Achievements |
The aims of this study were to focus on and analyze the hematopoietic regulatory system on the basis of three aspects, specifically focusing on a system that maintains hematopoietic stemness via hematopoietic stem/progenitor cell (HSPC) niches, the site of xenobiotic interrelationship. The first aim was to analyze the system during the dormancy period of HSPCs using several gene-modified mice with impaired hematopoiesis. The second aim was to examine the cellular and molecular mechanisms related to hematopoietic kinetic changes under oxidative stresses (e.g. induced by whole-body irradiation or benzene treatment). The third aim was to examine changes in the cell-cycle fraction during the senescent stage solely in relation to natural aging or in the presence of additional oxidative stresses such as those mentioned above. As a result, a functionally different regulatory/protecting systems were supposed to be present depending on the differentiation status of HSPCs.
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Report
(4 results)
Research Products
(37 results)
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[Presentation] Differences in regulation of gene expression profiles of the bone marrow between C57BL/6 and C3H/He mice after benzene treatment.
Author(s)
Hirabayashi, Y., Yoon, B.I., Igarashi, K., Kanno, J., Inoue, T.
Organizer
Society of Toxicology 52nd Annual Meeting & ToxExpo
Place of Presentation
Santa Fe TX, USA
Related Report
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[Presentation] Role of Connexin 32: maintenance of cell quiescence and support of proliferation of hematopoietic stem/progenitor cells.
Author(s)
Hirabayashi, Y., Yoon, B.I., Tsuboi, I., Kanno, J., Trosko, J.E., Inoue, T.
Organizer
The 41st Annual meeting for the International Society for Hematology and Stem Cells
Place of Presentation
Amsterdam, Netherlands
Related Report
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[Presentation] Dual Function of Cx32 in Hematopoiesis: Maintenance of cell quiescence and support of proliferation of hematopoietic stem/progenitor cells.
Author(s)
Hirabayashi, Y., Yoon, B.I., Tsuboi, I., Kanno, J., Trosko, J.E., Inoue, T
Organizer
The 10th Annual meeting for the International Society for Stem Cell Research (ISSCR)
Place of Presentation
横浜
Related Report
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