Re-profiling of protein kinase inhibitors for next generation molecular target therapy

• Project/Area Number: 24590469
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Hokkaido University
• Principal Investigator: TSUDA Masumi 北海道大学, 医学(系)研究科(研究院), 講師 (30431307)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 腫瘍 / 分子標的治療 / キナーゼ阻害剤 / 薬剤耐性 / シグナル伝達 / 分子標的治療薬 / キナーゼ阻害薬

Outline of Final Research Achievements

Several molecular therapeutics targeting protein tyrosine kinases have recently been attempted; however, an emerging drug resistance is a crucial issue. Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor. Despite technological advances in surgery, combined with regimens of radiotherapy and new generation chemotherapy with temozolomide, the median survival is still 15 months. Here, we established cell lines acquired drug resistance to individual tyrosine kinase inhibitor (TKI) for EGFR, c-Met, and PDGFR that highly expressed in GBM, and characterized the underlying mechanisms. We found that c-Met inhibitor effectively abrogated TKIs-dependent enhancement of phosphorylation of EGFR, although it did not effect on the ATP-binding ability of EGFR. In addition, the combination therapy of c-Met and PI3K inhibitors might be a powerful approach to abolish the TKI resistance for molecular target therapy in GBM, by inhibiting phosphorylations of Akt, Src, and p38 MAPK.

Research Products

• [Journal Article] CRK adaptor protein induces epithelial-mesenchymal transition and metastasis of bladder cancer cells via HGF/c-Met feedback loop. (2015)
  • Author(s): Matsumoto R, Tsuda M, Wang L, Maishi N, Abe t, Kimura T, Tanino M, Nishihara H, Hida K, Ohba Y, Shinohara N, Nonomura K, Tanaka S.
  • Journal Title: Cancer Sci Volume: in press Issue: 6 Pages: 709-17
  • DOI: 10.1111/cas.12662
  • Peer Reviewed / Open Access
• [Journal Article] Lysosomal interaction of Akt with Phafin2 : a critical step in the induction of autophagy (2014)
  • Author(s): M. Matsuda-Lennikov, F. Suizu, N. Hirata, M. Hashimoto, K. Kimura, T. Nagamine, Y. Fujioka, Y. Ohba, T. Iwanaga, and M. Noguchi
  • Journal Title: PLoS One Volume: 9 Issue: 5 Pages: 671-685
  • DOI: 10.1093/neuonc/not239
  • NAID: 120005385325
  • Peer Reviewed
• [Journal Article] Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastoma. (2014)
  • Author(s): Kohsaka, S., Hinohara, K., Wang, L., Nishimura, T., Urushido, M., Yachi, K., Tsuda, M., Tanino, M., Kimura, T., Nishihara, H., Gotoh, N., Tanaka, S.
  • Journal Title: Neuro Oncol. Volume: 16 Pages: 960-970
  • Peer Reviewed
• [Journal Article] C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma (2014)
  • Author(s): Kawamata F, Homma S, Kamachi H, Einama T, Kato Y, Tsuda M, Tanaka S, Maeda M, Kajino K, Hino O, Takahashi N, Kamiyama T, Nishihara H, Taketomi A, Todo S
  • Journal Title: J Gastroenterology Volume: 49 Issue: 1 Pages: 81-92
  • DOI: 10.1007/s00535-013-0773-6
  • NAID: 120005537455
  • Peer Reviewed
• [Journal Article] SS18-SSX-regulated miR-17 promotes tumor growth of synovial sarcoma by inhibiting p21WAF1/CIP1. (2014)
  • Author(s): Minami, Y., Kohsaka, S., Tsuda, M., Yachi, K., Hatori, N., Tanino, M., Kimura, T., Nishihara, H., Minami, A., Iwasaki, N., Tanaka, S.
  • Journal Title: Cancer Sci. Volume: 105 Issue: 9 Pages: 1152-1159
  • DOI: 10.1111/cas.12479
  • NAID: 120005515315
  • Peer Reviewed / Open Access
• [Journal Article] Differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma: a case report of an elderly man. (2014)
  • Author(s): Takahashi, K., Tsuda, M., Kanno, H., Murata, J., Mahabir, R., Ishida, Y., Kimura, T., Tanino, M., Nishihara, H., Nagashima, K., and Tanaka, S.
  • Journal Title: Brain Tumor Pathol. Volume: 31 Issue: 2 Pages: 118-23
  • DOI: 10.1007/s10014-013-0158-9
  • Peer Reviewed
• [Journal Article] Expression of CD163 prevents apoptosis through the production of granulocyte colony-stimulating factor in meningioma (2013)
  • Author(s): Kanno H, Nishihara H, Wang L, Yuzawa S, Kobayashi H, Tsuda M, Kimura T, Tanino M, Terasaka S, Tanaka S
  • Journal Title: Neuro-Oncology Volume: 15 Issue: 7 Pages: 853-64
  • DOI: 10.1093/neuonc/not028
  • Peer Reviewed
• [Journal Article] Relationship between Methyl CpG Binding Protein 2 and JC Viral Proteins (2013)
  • Author(s): Takahashi K, Orba Y, Kimura T, Wang L, Kohsaka S, Tsuda M, Tanino M, Nishihara H, Nagashima K, Sawa H, Tanaka S
  • Journal Title: Japanese Journal of Infectious Diseases Volume: 66 Issue: 2 Pages: 126-132
  • DOI: 10.7883/yoken.66.126
  • NAID: 130003381654
  • ISSN: 1344-6304, 1884-2836
  • Peer Reviewed
• [Journal Article] Combining integrated genomics and functional genomics to dissect the biology of a cancer-associated, aberrant transcription factor, the SAPSCR1-TFE3 fusion oncoprotein. (2013)
  • Author(s): Kobos, R., Nagai, M., Tsuda, M., Merl, MY., Saito, T., Laé, M., Mo, Q., Olshen, A., Lianoglou, S., Leslie, C., Ostrovnaya, I., Antczak, C., Djaballah, H., and Ladanyi, M.
  • Journal Title: J Pathol. Volume: 229 Issue: 5 Pages: 743-754
  • DOI: 10.1002/path.4158
  • Peer Reviewed
• [Journal Article] A Ca2+-dependent signaling circuit regulates influenza A virus internalization and infection (2013)
  • Author(s): Fujioka Y, Tsuda M, Nanbo A, Hattori T, Sasaki J, Sasaki T, Miyazaki T, Ohba Y
  • Journal Title: Nature Co㎜unnications Volume: 4 Issue: 1 Pages: 2-763
  • DOI: 10.1038/ncomms3763
  • Peer Reviewed
• [Journal Article] NS1-binding protein abrogates the elevation of cell viability by the influenza A virus NS1 protein in association with CRKL. (2013)
  • Author(s): Miyazaki M, Nishihara H, Hasegawa H, Tashiro M, Wang L, Kimura T, Tanino M, Tsuda M, Tanaka S.
  • Journal Title: Biochem Biophys Res Commun Volume: 441 Issue: 4 Pages: 953-7
  • DOI: 10.1016/j.bbrc.2013.11.011
  • NAID: 120005367439
  • Peer Reviewed
• [Journal Article] Fluorescent protein-based biosensors and their clinical applications. (2013)
  • Author(s): Ohba, Y., Fujioka, Y., Nakada, S., Tsuda, M.
  • Journal Title: Prog Mol Biol Transl Sci. Volume: 113 Pages: 313-348
  • DOI: 10.1016/b978-0-12-386932-6.00008-9
  • Peer Reviewed
• [Journal Article] The relationship between methyl CpG binding protein 2 and JC viral proteins. (2013)
  • Author(s): Takahashi K, Orba Y, Kimura T, Wang L, Kohsaka S, Tsuda M, Tanino M, Nishihara H, Nagashima K, Sawa H, Tanaka S.
  • Journal Title: Jpn J Infect Dis. Volume: 66 Pages: 126-132
  • NAID: 130003381654
  • Peer Reviewed
• [Journal Article] C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma. (2013)
  • Author(s): Kawamata F, Homma S, Kamachi H, Einama T, Kato Y, Tsuda M, Tanaka S, Maeda M, Kajino K, Hino O, Takahashi N, Kamiyama T, Nishihara H, Taketomi A, Todo S.
  • Journal Title: J Gastroenterol. Volume: in press
  • NAID: 120005537455
  • Peer Reviewed
• [Journal Article] Expression of CD163 prevents apoptosis through the production of granulocyte colony-stimulating factor in meningioma. (2013)
  • Author(s): Kanno H, Nishihara H, Wang L, Yuzawa S, Kobayashi H, Tsuda M, Kimura T, Tanino M, Terasaka S, Tanaka S.
  • Journal Title: Neuro Oncol. Volume: in press
  • Peer Reviewed
• [Journal Article] Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo. (2012)
  • Author(s): Arai R
  • Journal Title: European journal of cancer(Oxford,England:1990) Volume: 48 Issue: 15 Pages: 2417-2430
  • DOI: 10.1016/j.ejca.2011.12.028
  • Peer Reviewed
• [Journal Article] Roles for Crk in Cancer Metastasis and Invasion. (2012)
  • Author(s): Masumi Tsuda and Shinya Tanaka.
  • Journal Title: Genes & Cancer Volume: 3 Issue: 5-6 Pages: 334-340
  • DOI: 10.1177/1947601912458687
  • Peer Reviewed
• [Presentation] Mir-326 promotes tumor growth of human synovial sarcoma. (2015)
  • Author(s): Yusuke Minami, Masumi Tsuda, Shinji Kohsaka, Akio Minami, Shinya Tanaka, Norimasa Iwasaki
  • Organizer: 2015 Annual Meeting, Orthopaedic Research Society
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2015-03-28 – 2015-03-31
• [Presentation] High aldo-keto reductase 1C1 expression in metastatic bladder cancer cells associated with invasive potential and drug resistance. (2015)
  • Author(s): Ryuji Matsumoto, Masumi Tsuda, Nobuo Shinohara, Takashige Abe, Shinya Tanaka, Katsuya Nonomura.
  • Organizer: 30th Anniversary EAU Congress
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2015-03-20 – 2015-03-24
• [Presentation] Signaling adaptor protein CRK promotes epithelial-mesenchymal transition and metastasis of bladder cancer cells via HGF-Met signaling. (2015)
  • Author(s): Ryuji Matsumoto, Masumi Tsuda, Nobuo Shinohara, Takashige Abe, Shinya Tanaka, Katsuya Nonomura.
  • Organizer: 30th Anniversary EAU Congress
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2015-03-20 – 2015-03-24
• [Presentation] 27歳で発症し、11年の経過観察後に摘出された頚髄腫瘍の1例 (2015)
  • Author(s): 湯澤明夏、西原広史、岡田佳奈子、津田真寿美、田中伸哉
  • Organizer: 第114回東京脳腫瘍研究会
  • Place of Presentation: 東京医科大学（東京都）
  • Year and Date: 2015-01-17
• [Presentation] High Aldo-Keto Reductase 1C1 Expression in Metastatic Bladder Cancer Cells Associated with Invasive Potential and Drug Resistance. (2014)
  • Author(s): 松本隆児、津田真寿美、篠原信雄、安部崇重、田中伸哉、野々村克也
  • Organizer: 第66回西日本泌尿器科学会
  • Place of Presentation: 倉敷市芸文館・倉敷アイビースクエア（岡山県・倉敷市）
  • Year and Date: 2014-11-06 – 2014-11-08
• [Presentation] Preclinical evaluation of EZH2 inhibitors in models of human synovial sarcoma. (2014)
  • Author(s): Heike Keilhack, Satoshi Kawano, Sarah K. Knutson, Natalie M. Warholic, Jamie Kubica, Galina Kuznetsov, Shanqin Xu, Yonghong Xiao, Roy M. Pollock, Jesse S. Smith, Kevin K. Kuntz, Yukinori Minoshima, Masumi Tsuda, Shinya Tanaka, Robert A. Copeland
  • Organizer: Connective Tissue Oncology Society, 2014 Annual Meeting
  • Place of Presentation: InterContinental Berlin Hotel, Berlin, Germany
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] ヒト滑膜肉腫におけるmiR-326の機能解析 (2014)
  • Author(s): 三浪友輔、津田真寿美、高阪真路、田中伸哉、岩崎倫政
  • Organizer: 第29回日本整形外科学会基礎学術集会
  • Place of Presentation: 城山観光ホテル（鹿児島県・鹿児島市）
  • Year and Date: 2014-10-09 – 2014-10-10
• [Presentation] IGFBP2 in acquired drug resistance to TKIs targeting EGFR, c-Met, and PDGFR in glioblastoma (2014)
  • Author(s): Masumi Tsuda, Lei Wang, Mishie Tanino, Taichi Kimura, Hiroshi Nishihara, Shinya Tanaka
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (神奈川県・横浜市)
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Resistance to tyrosine kinase inhibitors: Transition from mesenchymal to stemness-like features in glioblastoma. (2014)
  • Author(s): Shinya Tanaka, Masumi Tsuda, Lei Wang, Michie Tanino, Taichi Kimura, Hiroshi Nishihara
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (神奈川県・横浜市)
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] MicroRNA miR-326 promotes tumor growth of human synovial sarcoma. (2014)
  • Author(s): Yusuke Minami, Masumi Tsuda, Shinji Kohsaka, Shinya Tanaka, Norimasa Iwasaki
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (神奈川県・横浜市)
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] EpiregulinはERK/MAPK pathwayを介して膠芽腫の腫瘍形成性を促進する (2014)
  • Author(s): 王磊、高坂真路、日野原邦彦、漆戸万沙那、谷内一博、津田真寿美、谷野美智枝、木村太一、西原広史、後藤典子、田中伸哉
  • Organizer: 第110回北海道癌談話会例会
  • Place of Presentation: 札幌医科大学（北海道・札幌市）
  • Year and Date: 2014-09-13
• [Presentation] EMT-stemnesss transition and functional properties of IGFBP2 in acquired drug resistance to TKIs targeting EGFR, c-Met, and PDGFR in glioblastoma. (2014)
  • Author(s): Masumi Tsuda, Lei Wang, Mishie Tanino, Taichi Kimura, Hiroshi Nishihara, Shinya Tanaka
  • Organizer: Cold Spring Harbor Laboratory Meeting, Mechanisms and Model of Cancer,
  • Place of Presentation: New York, USA
  • Year and Date: 2014-08-12 – 2014-08-16
• [Presentation] Crk adaptor protein induces EMT and metastasis via novel Rac1/Snail and RhoA/Slug signaling along with TGF-β1 positive feedback loop in lung cancer cell A549. (2014)
  • Author(s): Aiman Elmansuri, Mishie Tanino, Roshan Mahabir, Lei Wang, Taichi Kimura, Hiroshi Nishihara, Yasuhiro Hida, Hirotoshi Akita, Masumi Tsuda, Shinya Tanaka
  • Organizer: Cold Spring Harbor Laboratory Meeting, Mechanisms and Model of Cancer
  • Place of Presentation: New York, USA
  • Year and Date: 2014-08-12 – 2014-08-16
• [Presentation] グリオーマモデル細胞を用いる不死化・癌化に伴う糖鎖発現変動の解析 (2014)
  • Author(s): 古川潤一、津田真寿美、岡田和恵、木村太一、朴錦花、田中伸哉、篠原康郎
  • Organizer: 第33回日本糖質学会年会
  • Place of Presentation: 名古屋大学豊田講堂（愛知県・名古屋市）
  • Year and Date: 2014-08-10 – 2014-08-12
• [Presentation] ヒト滑膜肉腫におけるmiR-326の機能解析 (2014)
  • Author(s): 三浪友輔、津田真寿美、高阪真路、田中伸哉、岩崎倫政
  • Organizer: 第47回日本整形外科学会骨軟部腫瘍学術集会
  • Place of Presentation: 大阪国際会議場（大阪府・大阪市）
  • Year and Date: 2014-07-17 – 2014-07-18
• [Presentation] 診断と治療に苦慮し、急速な進行をたどったepithelioid gliosarcomaの症例 (2014)
  • Author(s): 岡本沙織、小森隆司、新田雅之、丸山隆志、村垣善浩、津田真寿美、田中伸哉、岡田芳和
  • Organizer: 第55回日本神経病理学会総会
  • Place of Presentation: 学術総合センター（東京都）
  • Year and Date: 2014-06-05 – 2014-06-07
• [Presentation] 悪性神経膠腫放射線照射後のSnailによるGlial-mesenchymal transition (GMT)の関与 (2014)
  • Author(s): 谷野美智枝、Roshan Mahabir、 Aiman Elimansuri、 王磊、木村太一、西原広史、伊東民雄、白土博樹、津田真寿美、田中伸哉
  • Organizer: 第32回日本脳腫瘍病理学会
  • Place of Presentation: あわぎんホール（徳島県・徳島市）
  • Year and Date: 2014-05-23 – 2014-05-24
• [Presentation] EGFR、c-Met、PDGFR阻害薬耐性膠芽腫細胞株における多能性獲得とIGFBP2の機能解析 (2014)
  • Author(s): 津田真寿美、王磊、谷野美智枝、木村太一、西原広史、田中伸哉
  • Organizer: 第32回日本脳腫瘍病理学会
  • Place of Presentation: あわぎんホール（徳島県・徳島市）
  • Year and Date: 2014-05-23 – 2014-05-24
• [Presentation] 免疫染色を用いたヒートマップ解析による膠芽腫の分子発現プロファイリング (2014)
  • Author(s): 西原広史、宮崎将也、木村太一、谷野美智枝、津田真寿美、田中伸哉
  • Organizer: 第32回日本脳腫瘍病理学会
  • Place of Presentation: あわぎんホール（徳島県・徳島市）
  • Year and Date: 2014-05-23 – 2014-05-24
• [Presentation] Pilomyxoid-spectrum astrocytoma２例の臨床病理学的検討-BRAF遺伝子異常の検討も加えて- (2014)
  • Author(s): 伊東民雄、佐藤憲市、及川光照、尾崎義丸、中村博彦、津田真寿美、田中伸哉、杉尾啓徳、浅野目卓、長嶋和郎
  • Organizer: 第32回日本脳腫瘍病理学会
  • Place of Presentation: あわぎんホール（徳島県・徳島市）
  • Year and Date: 2014-05-23 – 2014-05-24
• [Presentation] 膠芽腫におけるチロシンキナーゼ阻害薬耐性メカニズムの解析 (2013)
  • Author(s): 津田真寿美、王磊、谷野美智枝、木村太一、西原広史、田中伸哉
  • Organizer: 第３１回日本脳腫瘍病理学会
  • Place of Presentation: KFC Hall 国際ファッションセンター（東京）
• [Presentation] miR-23aによる神経膠芽腫の浸潤能亢進とその機能解析 (2013)
  • Author(s): 谷地一博、高阪真路、三浪友輔、王磊、木村太一、谷野美智枝、西原広史、津田真寿美、田中伸哉
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌、さっぽろ芸文館（札幌市）
• [Presentation] 髄膜腫におけるCD163発現の分子病理学的解析 (2013)
  • Author(s): 菅野 宏美、西原 広史、王磊、木村 太一、津田 真寿美、谷野 美智枝、田中 伸哉
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌、さっぽろ芸文館（札幌市）
• [Presentation] 新規シグナル特異的阻害剤スクリーニングシステムを用いた膠芽腫治療薬の探索 (2013)
  • Author(s): 王磊、津田真寿美、菅野宏美、木村太一、谷野美智枝、西原広史、田中伸哉
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌、さっぽろ芸文館（札幌市）
• [Presentation] 膠芽腫における分子標的治療薬耐性メカニズムの解明 (2013)
  • Author(s): 津田真寿美、王磊、谷野美智枝、木村太一、西原広史、田中伸哉
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌、さっぽろ芸文館（札幌市）
• [Presentation] CrkI and CrkII Promote Epithelial - Mesenchymal Transition in A549 Lung Cancer Cell Line. (2013)
  • Author(s): Aiman Elmansuri, Mishie Tanino, Roshan Mahabir, Lei Wang, Masumi Tsuda, Taichi, Kimura, Hiroshi Nishihara, Shinya Tanaka.
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌、さっぽろ芸文館（札幌市）
• [Presentation] Snail promotes glial-mesenchymal transition (GMT) after irradiation in malignant glioma. (2013)
  • Author(s): Mahabir Roshan、谷野美智枝、Elimansuri Aiman、津田真寿美、王磊、木村太一、西原広史、田中伸哉
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌、さっぽろ芸文館（札幌市）
• [Presentation] BRAF異常とグリオーマ (2013)
  • Author(s): 田中伸哉、谷野美智枝、津田真寿美、石田雄介、木村太一、西原広史、長嶋和郎
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌、さっぽろ芸文館（札幌市）
• [Presentation] 新規膀胱癌転移関連分子の同定を目的としたヒト膀胱癌同所性移植多臓器転移モデルの確立. (2013)
  • Author(s): 松本隆児、津田真寿美、王磊、木村太一、谷野美智枝、西原広史、篠原信雄、野々村克也、田中伸哉
  • Organizer: 第10回日本病理学会カンファレンス2013六甲山
  • Place of Presentation: 六甲山ホテル（神戸市）
• [Presentation] 膠芽腫における主要チロシンキナーゼEGFR、c-Met、PDGFRに対する分子標的治療薬耐性メカニズムの解明 (2013)
  • Author(s): 津田真寿美、王磊、谷野美智枝、木村太一、西原広史、田中伸哉
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜パシフィコ（横浜市）
• [Presentation] miR-17はp21を標的としヒト滑膜肉腫の細胞増殖能や腫瘍形成能を亢進させる (2013)
  • Author(s): 三浪友輔、津田真寿美、岩崎倫政、田中伸哉
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜パシフィコ（横浜市）
• [Presentation] Irradiation induces stem cell enrichment mediated by Snail in malignant glioma. (2013)
  • Author(s): Roshan Mahabir, Mishie Tanino, Aiman Elmansuri, Masumi Tsuda, Taichi Kimura, Lei Wang, Hiroshi Nishihara, Shinya Tanaka
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜パシフィコ（横浜市）
• [Presentation] CrkI and CrkII promote lung cancer metastasis via epithelial- mesenchymal transition (EMT) in A549 adenocarcinoma cells. (2013)
  • Author(s): Aiman Elmansuri, Mishie Tanino, Roshan Mahabir, Lei Wang, Masumi Tsuda, Taichi Kimura, Hiroshi Nishihara, Shinya Tanaka
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜パシフィコ（横浜市）
• [Presentation] Mechanisms of drug resistance to molecular target therapeutics against tyrosine kinases as EGFR,c-Met,andPDGFR in GBM. (2013)
  • Author(s): Masumi Tsuda, Lei wang, Mishie Tanino, Taichi Kimura, Hiroshi Nishihara, Shinya Tanaka.
  • Organizer: AACR-NCI-EORTC International Conference, Molecular Targets and Cancer Therapeutics.
  • Place of Presentation: Hynes Convention Center, Boston, USA
• [Presentation] The mesenchymal phenotype in recurrent glioblastoma is due to irradiation induced Snail expression and resultant EMT. (2013)
  • Author(s): Roshan Mahabir, Mishie Tanino, Aiman Elmansuri, Masumi Tsuda, Taichi Kimura, Lei Wang, Hiroshi Nishihara, Shinya Tanaka
  • Organizer: AACR-NCI-EORTC International Conference, Molecular Targets and Cancer Therapeutics.
  • Place of Presentation: Hynes Convention Center, Boston, USA
• [Presentation] CrkI and CrkII adaptor proteins promotes invasiveness and metastasis via epithelial-mesenchymal transition (EMT) in A549 lung adenocarcinoma cells. (2013)
  • Author(s): Aiman Elmansuri, Mishie Tanino, Roshan Mahabir, Lei Wang, Masumi Tsuda, Taichi Kimura, Hiroshi Nishihara, Shinya Tanaka
  • Organizer: AACR-NCI-EORTC International Conference, Molecular Targets and Cancer Therapeutics.
  • Place of Presentation: Hynes Convention Center, Boston, USA
• [Presentation] Let 7a regulates IL-6 expression in malignant mesothelioma. (2013)
  • Author(s): Mishie A. Tanino, Shinji Kohsaka, Kazuhiro Yachi, Masumi Tsuda, Taichi Kimura, Hiroshi Nishihara, Shinya Tanaka
  • Organizer: AACR-NCI-EORTC International Conference, Molecular Targets and Cancer Therapeutics.
  • Place of Presentation: Hynes Convention Center, Boston, USA
• [Presentation] The distinct role of CRKI, CRKII and CRKL in tumorigenesis of human head and neck squamous cell carcinoma. (2012)
  • Author(s): Hiroshi Nishihara, Hiroko Yanagi, Yusuke Fukushima, Teruki Yanagi, Lei Wang, Taichi Kimura, Mishie Tanino, Masumi Tsuda and Shinya Tanaka.
  • Organizer: Mechanisms & Models of Cancer Meeting
  • Place of Presentation: Salk Institute, USA
• [Presentation] Irradiation induced glial-mesenchymal transition in malignant glioma. (2012)
  • Author(s): Mahabir R, Tanino M, Elmansuri A, Kimura T, Tsuda M, Nishihara H, Tanaka S.
  • Organizer: 第７１回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌、さっぽろ芸文館、札幌市教育文化会館（札幌市）
• [Presentation] Involvement of CrkI and CrkII in epithelial-mesenchymal transition (EMT) and its role in lung metastasis. (2012)
  • Author(s): Aiman E, 谷野美智枝、mahabir R, 王磊, 木村太一、津田真寿美、西原広史、田中伸哉
  • Organizer: 第７１回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌、さっぽろ芸文館、札幌市教育文化会館（札幌市）
• [Presentation] 悪性グリオーマの分子病理学的解析：病理組織から治療薬へ (2012)
  • Author(s): 田中伸哉、高阪真路、﨓康一、王磊、津田真寿美、木村太一、谷野美智枝、西原広史、木村博道
  • Organizer: 第７１回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌、さっぽろ芸文館、札幌市教育文化会館（札幌市）
• [Presentation] Ras-PI3Kシグナルによる外来因子取込み制御機構の解析 (2012)
  • Author(s): 藤岡容一朗、津田真寿美、服部ともえ、佐々木純子、佐々木雄彦、宮崎忠昭、大場雄介
  • Organizer: 第３５回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場、マリンメッセ福岡（福岡県）
• [Presentation] RANKLはインテグリンa2の発現とエンドサイトーシスを介したインテグリンの細胞内輸送を亢進する (2012)
  • Author(s): 我妻孝則、津田真寿美、山田珠希、藤岡容一朗、芳賀永、戸塚靖則、進藤正信、大場雄介
  • Organizer: 第３５回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場、マリンメッセ福岡（福岡県）
• [Presentation] 新規シグナル特異的阻害剤スクリーニングシステムを用いた膠芽腫治療薬の探索
  • Author(s): 王磊、津田真寿美、菅野宏美、木村太一、谷野美智枝、西原広史、田中伸哉
  • Organizer: 第108回北海道癌談話会
  • Place of Presentation: 旭川グランドホテル（旭川市）
• [Presentation] BRAF遺伝子変異によるグリオーマの新規診断技術の検討
  • Author(s): 津田真寿美、谷野美智枝、木村太一、西原広史、田中伸哉
  • Organizer: 第46回北海道病理談話会
  • Place of Presentation: 北海道大学医学部フラテ会館（札幌市）
• [Book] Fluorescent protein-based biosensors and their clinical applications. (2013)
  • Author(s): Ohba Y, Fujioka Y, Nakada S, Tsuda M.
  • Publisher: Progress in Molecular Biology and Translational Science Volume 113. Fluorescece-Based Biosensors.
• [Book] Biosensors and Cancer (2012)
  • Author(s): Ohba Y, Darmanin S, Mizutani T, Tsuda M, Kondo T.
  • Publisher: Biosensors for BCR-ABL activity and their application to cancer.
• [Book] 細胞内シグナル伝達の可視化技術と分子標的治療薬の耐性判定への応用 (Visualization of intracellular signaling and its application to assessment of response to molecular target drugs) (2012)
  • Author(s): 大場雄介、津田真寿美
  • Publisher: 生化学ミニレビュー
• [Remarks] 北海道大学大学院医学研究科 腫瘍病理学分野
  • URL: http://patho2.med.hokudai.ac.jp/
• [Remarks] 北海道大学大学院医学研究科 腫瘍病理学分野
  • URL: http://patho2.med.hokudai.ac.jp/
• [Remarks] 北海道大学大学院医学研究科 腫瘍病理学分野
  • URL: http://patho2.med.hokudai.ac.jp/
• [Patent(Industrial Property Rights)] ホルマリン固定生体組織内での活性型低分子量GTP結合蛋白質検出方法 (2015)
  • Inventor(s): 田中伸哉、津田真寿美、谷野美智枝
  • Industrial Property Rights Holder: 田中伸哉、津田真寿美、谷野美智枝
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-03-05
• [Patent(Industrial Property Rights)] グリオーマの診断マーカー、診断方法、糖鎖マーカーを検出する方法及び糖鎖マーカー (2014)
  • Inventor(s): 篠原康郎、田中伸哉、古川潤一、津田真寿美
  • Industrial Property Rights Holder: 篠原康郎、田中伸哉、古川潤一、津田真寿美
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-08-08