| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that exhibit immunosuppressive activity in cancer. We have studied the effects of innate immune signaling activation on MDSC function. A double-stranded (ds) RNA adjuvant induced IFN-α production by MDSCs through MAVS (IPS-1) signaling pathway, leading to NK cell activation. dsRNA adjuvant stimulation also converted MDSCs into cells with anti-tumor activity through TICAM-1 (TRIF) signaling pathway. In contrast, Pam2 lipopeptide-induced toll-like receptor 2 (TLR2) activation resulted in enhanced survival and immunosuppressive activity of MDSCs. Thus, our data suggest that innate immune signaling is closely related to expansion and function of MDSCs.
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