Regulation of function of tumor-infiltrating myeloid cells by RNA adjuvant
| Project/Area Number |
24590470
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
SHIME Hiroaki 北海道大学, 医学(系)研究科(研究院), 助教 (70372133)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | がん免疫 / ミエロイド系細胞 / アジュバント / マクロファージ / TLR / MDSC / がん免疫療法 / 免疫抑制 / 自然免疫 / ミエロイド / 癌免疫療法 / 腫瘍随伴マクロファージ(TAM) / RNAアジュバント / 免疫抑制細胞 / IPS-1 MAVS / NK細胞 / インターフェロン |
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| Outline of Final Research Achievements |
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that exhibit immunosuppressive activity in cancer. We have studied the effects of innate immune signaling activation on MDSC function. A double-stranded (ds) RNA adjuvant induced IFN-α production by MDSCs through MAVS (IPS-1) signaling pathway, leading to NK cell activation. dsRNA adjuvant stimulation also converted MDSCs into cells with anti-tumor activity through TICAM-1 (TRIF) signaling pathway. In contrast, Pam2 lipopeptide-induced toll-like receptor 2 (TLR2) activation resulted in enhanced survival and immunosuppressive activity of MDSCs. Thus, our data suggest that innate immune signaling is closely related to expansion and function of MDSCs.
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Report
(4 results)
Research Products
(31 results)
