Development of histologically accurate brain tumor mouse models for preclinical trial
| Project/Area Number |
24590478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokyo (2014-2015)
Nagoya University (2012-2013) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脳腫瘍 / マウスモデル / 前臨床試験 / 生体イメージング / 神経膠腫 / 髄芽腫 / トランスレーショナルリサーチ |
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| Outline of Final Research Achievements |
Malignant brain tumors are the most devastating human cancers and accurate mouse models of these tumors are essential in order to develop optimal therapies. The RCAS/tv-a mouse model system is used to create histologically accurate brain tumors by RCAS virus-mediated gene transfer into the brain cells expressing tv-a receptor. I have introduced and established these mouse models first in Japan, successfully developed brain tumors in mice, and investigated drug efficacy and the mechanisms of tumorigenesis. These results will further expand the research on brain tumor biology and the development of new treatments for brain tumors.
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Report
(5 results)
Research Products
(19 results)
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[Journal Article] Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase.2015
Author(s)
Ohkawa Y, Momota H, Kato A, Hashimoto N, Tsuda Y, Kotani N, Honke K, Suzumura A, Furukawa K, Ohmi Y, Natsume A, Wakabayashi T, Furukawa K.
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Journal Title
J Biol Chem.
Volume: 290
Issue: 26
Pages: 16043-16058
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Assessment of tumor cells in a mouse model of diffuse infiltrative glioma by Raman spectroscopy.2014
Author(s)
Tanahashi K, Natsume A, Ohka F, Momota H, Kato A, Motomura K, Watabe N, Muraishi S, Nakahara H, Saito Y, Takeuchi I, Wakabayashi T.
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Journal Title
Biomed Res Int.
Volume: 2014
Pages: 860241-860241
DOI
Related Report
Peer Reviewed / Open Access
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