| Project/Area Number |
24590480
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KIN Tetsushou 滋賀医科大学, 医学部, 非常勤講師 (10204968)
MUKAISHO Ken-ichi 滋賀医科大学, 医学部, 准教授 (50343223)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | Cyclin D1b / トランスジェニックマウス / 直腸腫瘍 / エストロゲンレセプター / Akt / Erk / cyclin D1b / 無茎性鋸歯状腺腫 / エストロゲン受容体 / SSA/P / 腺癌 |
|---|
| Outline of Final Research Achievements |
Cyclin D1b, a splicing variant of cyclin D1, is hardly expressed in normal tissues but is frequently expressed in certain types of cancer tissues. To clarify the role of cyclin D1b in tumorigenesis, we developed cyclin D1b transgenic (Tg) mice and found the rectal tumors, including adenocarcinoma and sessile serrated adenoma (SSA) in 62.5% of female Tg mice. We also found that enhanced phosphorylation of Akt and Erk plays a critical role for rectal tumorigenesis by cyclin D1b. No rectal tumors were found in the ovariectomized female cyclin D1b Tg mice, indicating that female sex hormones played a critical role in rectal carcinogenesis in these Tg mice. Enhanced expression of estrogen receptor by cyclin D1b was involved in this female-specific recral tomorigenesis. These cyclin D1b Tg mice would provide an excellent model system for investigating the molecular mechanism of development of SSA and the progression from these precancerous lesions to adenocarcinomas in colorectal cancer.
|
