| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis and can colonize genetically infertile testes. Previous result demonstrated that Rac1 mediated CLDN3 expression is necessary for homing of SSCs. Although atypical PKC (aPKC) molecule, such as PKCl and PKCz are known to regulate expression of tight junction molecules including CLDN3, Role of aPKC in SSC homing remained unknown.
In the present study, we tried to unveil the role of aPKC molecules in SSC homing using aPKC conditional knockout mice. However, our SSC transplantation assay revealed that aPKC molecules were dispensable for SSC homing.
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