Biological analysis of miR-210 which is deregulated in clear cell renal cell carcinoma.
Project/Area Number |
24590485
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Oita University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | microRNA / トランスジェニックマウス / 腎臓 / 腎細胞癌 |
Outline of Final Research Achievements |
Previously, I have reported that miR-210 is constitutively upregulated in clear cell renal cell carcinoma because of the deregulation of VHL-HIF axis. To elucidate whether the upregulation of miR-210 is involved in the tumorigenesis and/or progression of renal cell carcinoma, I addressed the following two issues, 1) the identification of the target genes of miR-210 and 2) the observation of biological effect of miR-210 upregulation on renal tubules in vivo. Research results; A miR-210 target gene which is conserved as target between human and mouse was identified by microarray analysis. MiR-210 transgenic mice which express miR-210 in renal proximal tubules were established and histopathologically analyzed. Tg-mice kept alive without specific symptoms and development of renal carcinoma at least for 96 weeks. The chronic inflammations were observed in kidneys of young Tg-mice, and their renal function was diminished with aging. The overexpression of miR-210 may damage the renal tubules.
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Report
(5 results)
Research Products
(11 results)
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[Journal Article] Kidney-specific knockout of Sav1 in the mouse promotes hyper-proliferation of renal tubular epithelium through suppression of the Hippo pathway.2016
Author(s)
Kai T, Tsukamoto Y, Hijiya N, Tokunaga A, Nakada C, Uchida T, Daa T, Iha H, Takahashi M, Nomura T, Sato F, Mimata H, Ikawa M, Seto M, Matsuura K, Moriyama M.
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Journal Title
J Pathol.
Volume: 印刷中
Issue: 1
Pages: 97-108
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma.2016
Author(s)
Takahashi M, Tsukamoto Y, Kai T, Tokunaga A, Nakada C, Hijiya N, Uchida T, Daa T, Nomura T, Sato F, Mimata H, Matsuura K, Moriyama M.
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Journal Title
Cancer Science
Volume: 107(4)
Issue: 4
Pages: 417-423
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Downregulation of NDUFB6 due to 9p24.1-p13.3 loss is implicated in metastatic clear cell renal cell carcinoma.2015
Author(s)
Narimatsu T, *Matsuura K, Nakada C, Tsukamoto Y, Hijiya N, Kai T, Inoue T, Uchida T, Nomura T, Sato F, Seto M, Takeuchi I, Mimata H, Moriyama M
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Journal Title
Cancer Medicine
Volume: 4(1)
Issue: 1
Pages: 112-124
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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