Exploratory analysis for functional genes which play critical roles in malignant features of glioblastoma
| Project/Area Number |
24590486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 癌 / 遺伝子 / 細胞・組織 / 病理学 / 脳神経疾患 / 膠芽腫 / 浸潤 / 実験病理 / glioblastoma / IGFBP-2 / CD24 / がん幹細胞 |
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| Outline of Final Research Achievements |
Glioblastoma is a malignant brain tumor with miserable prognosis, and breakthrough on treatment against this malignant tumor is required. We performed exploretary analysis for novel functional genes which play important roles in malignant features of glioblastoma with a central focus on IGFBP2 and CD24.
Several mechanisms of chemoresistance of glioblastoma are discovered. It was revealed that RelA enhances the expression of IGFBP2 in glioblastoma cells, and inhibition of RelA reduced in vitro-proliferative activity and in vivo-tumorigenicity of glioblastoma cells. Not a few pancreatic ductal adenocarcinoma cell lines also express IGFBP2 and CD24.
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Report
(4 results)
Research Products
(18 results)
