Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Outline of Final Research Achievements |
In renal tubulointerstitial fibrosis, tubular epithelial cells are stimulated by various factors and transform from epithelial cells to mesenchymal cells. This epithelial to mesenchymal transition is caused by transforming growth factor (TGF) - beta, which promotes interstitial fibrosis. In this study, we forcused on the relationship between phosphate/calcium metabolism and renal interstitial fibrosis and investigated how a loss of Klotho influenced the degree of fibrosis. As a result, we found that the total loss of Klotho increases the active form of vitamin D, which in turn inhibits TGF-beta signaling, resulting in suppressing tubulointerstitial fibrosis.
|