Research and development of human neutralizing antibodies aiming at treatment of non-small cell lung carcinoma
| Project/Area Number |
24590490
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKADA Yasunori 慶應義塾大学, 医学部, 教授 (00115221)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ADAM / 分子標的 / 肺癌 / 癌転移 / 分子標的治療 / VWF / 癌細胞増殖 / ヒト型抗体 |
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| Outline of Final Research Achievements |
ADAM28, a member of the ADAM (a disintegrin and metalloproteinase) gene family, plays an important role in cancer cell proliferation and metastasis. In the present study, we screened Human Combinatorial Antibody Library by phage display panning and obtained antibodies (211-14 and 211-12) against ADAM28. Tumor growth and metastasis of the lung tumors after intravenous injection of PC-9 ffLuc-cp156 lung carcinoma cells were significantly inhibited by the antibody treatment, improving survival rate of the mice. These data indicate that our antibodies 211-14 and 211-12 neutralize ADAM28 activity and antibody 211-14 inhibits cancer cell proliferation and metastasis in vivo. The antibodies could be used as an ADAM28 inhibitor for clinical application to treat the patients with lung or breast carcinoma in the future.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] ADAM28 is elevated with the metabolic syndrome and is a sheddase of human tumour necrosis factor2012
Author(s)
Jowett J.B.M., Okada Y., Leedman P.J., Curran J.E., Johnson M.P., Moses E.K., Goring H.H.H., Mochizuki S., Blangero J., Stone L., Allen H., Mitchell C. and Matthews V.B
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Journal Title
Immunology & Cell Biology
Volume: 90
Pages: 966-973
DOI
Related Report
Peer Reviewed
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[Journal Article] Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy2012
Author(s)
Murata M, Noda K, Fukuhara J, Kanda A, Kase S, Saito W, Ozawa Y, Mochizuki S, Kimura S, Mashima Y, Okada Y, Ishida S.
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Journal Title
Investigative Ophthalmology & Visual Science
Volume: 53
Pages: 4055-4062
DOI
Related Report
Peer Reviewed
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