| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
By using cDNA library of interstitial cells of Cajal(ICCs), we first clarified that CADM1, one of cell adhesion molecules, is specifically expressed by ICCs. We investigated CADM1 expression in gastrointestinal stromal tumors (GISTs) which are considered to be originated from ICCs, and found that most of GISTs in the small intestine express CADM1, but most of gastric GISTs do not. The specific expression of CADM1 in small intestinal GISTs might mean that specific expression of CADM1 in ICCs in the small intestine. ICCs in different sites may show different protein expression pattern and may have different role.
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