Investigation of mechanisms to keep blood vessels patent in hepatocellular carcinoma.

• Project/Area Number: 24590499
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kanagawa Cancer Center Research Institute
• Principal Investigator: MIYAGI Yohei 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 総括部長 (00254194)
• Co-Investigator(Kenkyū-buntansha): KOIZUME Shiro 神奈川県立がんセンター臨床研究所, 主任研究員 (60416063)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 凝固第VII因子 / 組織因子 / 凝固 / 肝がん / TFPI / TF / fVII / 肝細胞癌 / 血栓塞栓 / tissue factor / 血液凝固第7因子 / 血液凝固

Outline of Final Research Achievements

Hepatocellular carcinoma (HCC) cells produce both blood coagulation factor-VII (fVII) and tissue factor (TF). We clarified in the present study that under such circumstances, HCC cells do not elicit TF-fVIIa blood coagulation pathway because of ectopic tissue factor pathway inhibitor (TFPI)-1 production. At least in HCC cells, there exist a mechanism to keep patency of tumor vessels, that could be a good target for novel anticancer therapy.

Research Products

• [Journal Article] Breast cancer phenotypes regulated by tissue factor-factor VII pathway: Possible therapeutic targets. (2014)
  • Author(s): Koizume, S and Miyagi, Y.
  • Journal Title: World J Clin Oncology Volume: 5(5) Issue: 5 Pages: 908-920
  • DOI: 10.5306/wjco.v5.i5.908
  • Peer Reviewed / Open Access
• [Journal Article] Angiomodulin (AGM/IGFBP-rP1) is a molecular marker of vascular endothelial cells activated by VEGF in human breast cancers. (2014)
  • Author(s): Komiya, E, Sato, H., Ise, I., Watanabe, N., Higashi, H., Miyagi, Y., Miyazaki, K.
  • Journal Title: Cancer Med Volume: 印刷中 Issue: 3 Pages: 537-549
  • DOI: 10.1002/cam4.216
  • Peer Reviewed / Open Access
• [Journal Article] HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells (2012)
  • Author(s): Koizume S, Ito S, Miyagi E, Hirahara F, Nakamura Y, Sakuma Y, Osaka H, Takano Y, Ruf W, Miyagi Y
  • Journal Title: Nucleic Acid Research Volume: 40(12) Issue: 12 Pages: 5389-5401
  • DOI: 10.1093/nar/gks201
  • Peer Reviewed
• [Presentation] 肝細胞癌で発見する異所性TFPI1による癌細胞での接着阻害
  • Author(s): 伊藤 慎，小井詰史朗、高野康雄、宮城洋平
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌