Analysis of factors involvement of specificity of phagocytosis in Entamoeba histolytica
| Project/Area Number |
24590514
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分子 / Rab GTPase / 貪食 / 小胞体 / 寄生性原虫 / ゴルジ体 / 膜輸送 / 国際情報交換 |
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| Outline of Final Research Achievements |
Phagocytosis is indispensable for the pathogenesis of the intestinal protozoan parasite Entamoeba histolytica. This report showed that in E. histolytica Rab8A, which is generally involved in trafficking from the trans-Golgi network to the plasma membrane in other organisms, but was previously identified in phagosomes of the ameba in the proteomic analysis, primarily resides in the endoplasmic reticulum (ER) and participates in phagocytosis.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] The cell surface proteome of Entamoeba histolytica2014
Author(s)
Laura Biller, Jenny Matthiesen, Vera Kuhne, Hannelore Lotter, Ghassan Handal, Tomoyoshi Nozaki, Yumiko Saito-Nakano, Michael Schumann, Thomas Roeder, Egbert Tannich, Eberhard Krause, and Iris Bruchhaus
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Journal Title
Molecular and Cellular Proteomics
Volume: 13
Issue: 1
Pages: 132-144
DOI
Related Report
Peer Reviewed
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