New biologicol activity of staphylococcal enterotoxin: Elucidation of neurotoxic effects and its mechanism
| Project/Area Number |
24590516
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | エンテロトキシン / ブドウ球菌 / 病原性 / 神経細胞 / 嘔吐活性 / 神経毒 / 嘔吐 |
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| Outline of Final Research Achievements |
Staphylococcal enterotoxin (SE) is an important bacterial toxin that involved in human diseases including food poisoning and toxic shock syndrome. We have been studied the emetic activity and its mechanism of SE, used a small vomiting animal model, house musk shrews. In this study, a new feature-neurotoxic effects of SE were studied. In house musk shrews experiments, SE showed vomiting activity, but it does not have the diarrhea activity. The vomiting of house musk shrews was also inhibited by administering antagonists of nerve cell receptors. In addition, we examined the binding of the toxin and the nerve cells in culture,the release with the production of such 5-HT in the cells.SE did not show toxicity in nerve cells, but it binds to neuronal cells, stimulates cellular signal transduction material, and revealing the SE has neuronal intracellular signal redulatory functions.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Molecular epidemiology and identification of a Staphylococcus aureus clone causing food poisoning outbreaks in Japan.2014
Author(s)
Sato’o, Y., Omoe, K., Naito, I., Ono, H. K., Nakane, A. Sugai, M., Yamagishi, N. and Hu, D.-L.
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Journal Title
J. Clin. Microbiol.
Volume: 52
Pages: 2637-2640
Related Report
Peer Reviewed
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[Journal Article] Molecular epidemiological characterization of Staphylococcus aureus isolates originating from food poisoning outbreaks that occurred in Tokyo, Japan.2014
Author(s)
Suzuki, Y., Omoe, K., Hu, D.-L., Sato’o, Y., Ono, H., Monma, C., Arai, T.;, Konishi, N., Kato, R., Hirai, A., Nakama, A., Kai, A., Kamata, Y.
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Journal Title
Microbiol. Immunol.
Volume: 58
Pages: 570-580
NAID
Related Report
Peer Reviewed
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[Presentation] Elucidation of biological characteristics and emetic activities of newly identified staphylococcal enterotoxins．2014
Author(s)
Hu, D.-L.,Okamura, M., Ono, H. K., Nakane, A., Imanishi, K．
Organizer
International Symposium on Microbiology (IUMS)
Place of Presentation
Convention Center, Montreal, Canada.
Year and Date
2014-07-21 – 2014-08-01
Related Report
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[Presentation] Emetic potential of newly identified staphylococcal enterotoxin-like toxins in cynomolgus monkey and house musk shrew．2014
Author(s)
Ono, H. K., Omoe, K., Hirose, S., Hu, D.-L., Imanishi, K., Nakane, A．
Organizer
The 12th Japan-Korea International Symposium on Microbiology (XII-JKISM).
Place of Presentation
Tower Hall Funabori, Tokyo Japan
Related Report
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[Presentation] Emetic potentiona od newly identified staphylococcal superantigens.2013
Author(s)
Imanishi, K., Omoe, K., Ono, H.K., Kato, H., Shinagawa, K., Yagi, J., Nakane, A., Uchiyama, T. Hu, D.-L.
Organizer
15th International Congress of Immunology.
Place of Presentation
MiCo - Milano Congressi, Milan, Italy
Related Report
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