Regulation of autophagy by endogenously produced hydrogen sulfide anion and its physiological functions
| Project/Area Number |
24590527
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Tohoku University (2014)
Kumamoto University (2012-2013) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 硫化水素 / オートファジー / 感染防御 / 細菌 / 病原性 |
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| Outline of Final Research Achievements |
The present study revealed that a sulfur-containing compound cysteine persulfide and a nitrated cyclic nucleotide 8-nitro-cGMP are involved in the regulation of autophagy and antibacterial host defense. Also, it showed that hydrogen sulfide produced by bacteria inhibits the autophagy induction in host cells and may contribute to the growth of bacteria in infected cells.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses.2014
Author(s)
Khan S, Rahman H N A, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T, Yoshitake J, Ono K, Ahmed K A, Rahaman M d M, Oyama K, Takeya M, Ida T, Kitamura Y, Fujii S, Akaike T.
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Journal Title
Sci. Rep.
Volume: (印刷中)
Issue: 1
Pages: 4680-4680
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.2014
Author(s)
Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: (印刷中)
Issue: 21
Pages: 7606-7611
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria.2013
Author(s)
Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H.
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Journal Title
Mol. Cell
Volume: 52
Issue: 6
Pages: 794-804
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] タンパク質ポリサルファー化による酸化ストレス・レドックスシグナル制御2014
Author(s)
藤井重元、井田智章、居原 秀、笠松真吾、ジョン ミンギョン、赤司壮一郎、松永哲郎、津々木博康、澤 智裕、本橋ほづみ、熊谷嘉人、赤池孝章.
Organizer
生理学研究所研究会「新規シグナル伝達分子とその生理学的可能性」
Place of Presentation
大学共同利用機関法人自然科学研究機構NIPS 生理学研究所１階大会議室（愛知県岡崎市）
Year and Date
2014-09-18 – 2014-09-19
Related Report
Invited
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