| Project/Area Number |
24590530
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Soh 札幌医科大学, 医学部, 助教 (10588479)
FUJII Nobuhiro 札幌医科大学, 医学部, 教授 (90133719)
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| Research Collaborator |
KONNO Mutsuko 札幌厚生病院, 小児科
FUJIWARA Shin-ichi 札幌厚生病院, 小児科
TOITA Nariaki 札幌厚生病院, 小児科
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ヘリコバクター・ピロリ / 感染免疫 / リポ多糖 / 炎症 / エピトープ / 発癌 / 抗原性 / 糖鎖抗原 / 菌株多様性 / Toll-like receptor |
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| Outline of Final Research Achievements |
Helicobacter pylori lipopolysaccharide (LPS) can divide highly-antigenic epitope-carrying one and weakly-antigenic epitope-carrying one. We found that weakly-antigenic epitope-carrying LPS enhanced Escherichia coli LPS-induced IL-8 production by upregulation of Toll-like receptor 4 expression in cooperation with host surfactant protein D, which specifically interacted with the weakly-antigenic LPS. The weakly-antigenic LPS-carrying H. pylori is more frequently found in gastric tumor than other gastroduodenal diseases. In this study, we did not observe relationship between the antigenicity of LPS and pathogenesis of H. pylori-related iron deficiency anemia.
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