Genome and virulence factor analysis of streptococci affected to chronic inflammatory diseases including primary biliary cirrhosis
| Project/Area Number |
24590536
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Tokyo Women's Medical University (2014-2015)
Juntendo University (2012-2013) |
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Principal Investigator |
KIKUCHI KEN 東京女子医科大学, 医学部, 教授 (60214748)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 原発性胆汁性肝硬変 / S. intermedius / histone-like protein / S. anginosus group / competence / HLP / S. anginosus / S. constellatus / transformation / gp210 / molecular mimic / ELISA / horizontal transfer / house keeping gene / Streptococcus anginosus |
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| Outline of Final Research Achievements |
Chronic inflammation like periodontitis caused by Streptococcus intermedius (SI) contributed to the etiology and progression of primary biliary cirrhosis (PBC), which occurred in menopausal females mainly. The continuous and localized production of histone-like protein was one of the mechanism of the pathogenesis of PBC. SI, one of the members of S. anginosus group, had uniform genetic backgrounds compared as other species, and the result was due to co-evolution with human in specialized niche environments.
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Report
(5 results)
Research Products
(26 results)
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[Journal Article] Frequent occurrence of fever in patients who have undergone endoscopic submucosal dissection for colorectal tumor, but bacteremia is not a significant cause.2014
Author(s)
Izumi K, Osada T, Sakamoto N, Kodani T, Higashihara Y, Ritsumo H, Shibuya T, Nagahara A, Ogihara T, Kikuchi K, Watanabe S.
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Journal Title
Surg Endosc
Volume: 28
Issue: 10
Pages: 2899-2904
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of commensal bacteria may lead to dysregulated inflammatory and autoimmune responses in a mouse model for chronic nonsuppurative destructive cholangitis2012
Author(s)
HARUTA Ikuko, KIKUCHI Ken, NAKAMURA Minoru, HIROTA Katsuhiko, KATO Hidehito, MIYAKAWA Hiroshi, SHIBATA Noriyuki, MIYAKE Yoichiro, HASHIMOTO Etsuko, SHIRATORI Keiko, YAGI Junji
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Journal Title
Journal of clinical immunology
Volume: 32(5)
Issue: 5
Pages: 1026-1037
DOI
Related Report
Peer Reviewed
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