Isolation of humonal monoclonal antibody cross-reactively neutralizing against shiga toxin type 1 and 2 and treating a patient suffering HUS
| Project/Area Number |
24590539
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Fujita Health University |
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Principal Investigator |
TSUJI Takao 藤田保健衛生大学, 医学部, 教授 (60171998)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腸管出血性大腸菌 / 致死毒素（Stx1と2） / 経鼻投与ワクチン / ヒトモノクローナル抗体 / HUS治療薬 / 腸管出血性大腸菌(EHEC) / HUS / Stx1と2 / 抗体治療薬 / Stx2B-His / ニワトリIgY |
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| Outline of Final Research Achievements |
Enterohemorrhagic Escherichia coli (EHEC) produces Stx1 and Stx2 causing severe diseases like hemolytic uremic syndrome (HUS). As there is no vaccine or no curative for these diseases caused by both toxins, we have been trying to isolate monoclonal antibody or polyclonal antibodies cross-reactively neutralizing both toxins. We already reported that nasal subunit-vaccine such as Stx2B-His with a mutant heat-labile enterotoxin induced polyclonal antibodies cross-reactively neutralizing both toxins （Vaccine,24:3591,2006、26:469,2008、26:2092.2008）.Then, in this project, we try to isolate a monoclonal antibody, which will neutralize both toxins cross-reactively and use for the treatment of severe diseases like HUS caused by both toxins.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Whole genomic analysis of human G12P[6] and G12P[8] rotavirus strains that have emerged in Kenya: Identification of porcine-like NSP4 genes.2014
Author(s)
Komoto S, Wandera Apondi E, Shah M, Odoyo E, Nyangao J, Tomita M, Wakuda M, Maeno Y, Shirato H, Tsuji T, Ichinose Y, Taniguchi K.
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Journal Title
Infect Genet Evol.
Volume: 27
Pages: 277-293
Related Report
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[Journal Article] Randomized placebo-controlled clinical trial of immunoglobulin Y as adjunct to standard supportive therapy for rotavirus-associated diarrhea among pediatric patients2012
Author(s)
Rahman S, Higo-Moriguchi K, Htun KW, Taniguchi K, Icatlo FC Jr, Tsuji T, Kodama Y, Van Nguyen S, Umeda K, Oo HN, Myint YY, Htut T, Myint SS, Thura K, Thu HM, Fatmawati NN, Oguma K
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Related Report
Peer Reviewed
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