| Project/Area Number |
24590541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kagawa Prefectural College of Health Sciences |
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Principal Investigator |
OKUDA Jun 香川県立保健医療大学, 保健医療学部, 教授 (90334276)
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| Co-Investigator(Kenkyū-buntansha) |
後藤 直正 京都薬科大学, 薬学部, 教授 (30121560)
皆川 周 京都薬科大学, 薬学部, 助教 (50445962)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 緑膿菌 / 内因性血液感染 / 上皮細胞透過メカニズム / 病原性発現メカニズム / 内因性血液感染メカニズム / 組織上皮透過メカニズム / 感染予防 / III型エフェクター / ExoS / 宿主因子KIF7 / 細胞傷害機構 / 線毛 / pilA / CAMLG / カルシウム / 細胞傷害 |
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| Outline of Final Research Achievements |
The type III effector exoS gene and genes encoding type IV pili were previously identified through CGH analysis. We focused on these genes, and revealed that type IV pili had ability to cause increase in Ca2+ concentration of epithelial cells through binding to Ca2+ regulator CAMLG, and it was also found that ExoS had ability to cause necrosis of human epithelial cells through binding to host factor KIF7.
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