Comparative genome analysis of M. leprae
Project/Area Number |
24590544
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Bacteriology (including Mycology)
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
KAI MASANORI 国立感染症研究所, その他部局等, 室長 (10291147)
|
Co-Investigator(Renkei-kenkyūsha) |
KURODA Makoto 国立感染症研究所, 病原体ゲノム解析研究センター, センター長 (80317411)
SEKIZUKA Takeshi 国立感染症研究所, 病原体ゲノム解析研究センター, 主任研究官 (40462775)
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Research Collaborator |
NAKATA Noboru
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | ハンセン病 / らい菌 / ゲノム / 少菌型 / 多菌型 / SNPs / genotyping |
Outline of Final Research Achievements |
Leprosy is caused by Mycobacterium leprae and classified into multi-bacillary (MB) and pauci-bacillary (PB). Objectives and results of this study were as follows. (1) The genome sequence of M. leprae isolated from MB patient in Honshu islands of Japan was determined and compared with two genome sequences (isolated from India and Brazil) registered in database. Some characteristic features were found in the genome of Japanese isolate. (2) The SNPs pattern on the regions in M. leprae strains isolated in East Asia or Southeast Asia was investigated. And we found that many of Korean isolates and Honshu isolates showed identical characteristic SNPs pattern. (3) The number of M. leprae bacilli in PB patient was extremely small. We acquired some information of genome sequence in M. leprae derived from PB patient but not finished completely.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Genome-wide re-sequencing of multidrug-resistant Mycobacterium leprae Airaku-32014
Author(s)
Singh P, Benjak A, Carat S, Kai M, Busso P, Avanzi C, Paniz-Mondolfi A, Peter C, Harshman K, Rougemont J, Matsuoka M, Cole ST
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Journal Title
Clin Microbiol Infect
Volume: 20
Issue: 10
Pages: 0619-0622
DOI
Related Report
Peer Reviewed / Open Access
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