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Understanding of mechanisms of avian influenza virus adaptation to humans.

Research Project

Project/Area Number 24590549
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Virology
Research InstitutionThe University of Tokyo

Principal Investigator

YAMADA SHINYA  東京大学, 医科学研究所, 助教 (90466839)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsインフルエンザ / 適応
Outline of Final Research Achievements

To better understand how H5N1 influenza viruses could become to replicate and transmit efficiently among humans, we analyzed mutations occurred in H5N1 viruses through the adaptation to normal human bronchial epithelial (NHBE) cells. We found some HA mutations responsible for the efficient replication in NHBE cells affected thermal stability, fusion activity and cytotoxicity, suggesting such mutations might confer the phenotype of seasonal human viruses to avian H5N1 viruses.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] Mammalian Adaptive Mutations of the PA Protein of Highly Pathogenic Avian H5N1Influenza Virus.2015

    • Author(s)
      Yamaji R, YamadaS, Le MQ, Ito M, Sakai-Tagawa Y, KawaokaY.
    • Journal Title

      Journal of Virology

      Volume: 89 Pages: 4117-4125

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification of PB2 mutations responsible for the efficient replication of H5N1 influenza viruses in human lung epithelial cells.2015

    • Author(s)
      Yamaji R, Yamada S, Le MQ, Li C, Chen H, Qurnianingsih E, Nidom CA, Ito M, Sakai-Tagawa Y, Kawaoka Y.
    • Journal Title

      J Virol.

      Volume: 89 Issue: 7 Pages: 3947-3956

    • DOI

      10.1128/jvi.03328-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Virulence-Affecting Amino Acid Changes in the PA Protein of H7N9 Influenza A Viruses.2014

    • Author(s)
      Yamayoshi S, Yamada S, Fukuyama S, Murakami S, Zhao D, Uraki R, Watanabe T, Tomita Y, Macken C, Neumann G, Kawaoka Y
    • Journal Title

      Journal of Virology

      Volume: 88(6) Issue: 6 Pages: 3127-34

    • DOI

      10.1128/jvi.03155-13

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of H7N9 influenza A viruses isolated from humans.2013

    • Author(s)
      Watanabe T, Kiso M, Fukuyama S, Nakajima N, Imai M, Yamada S, Murakami S, Yamayoshi S, Iwatsuki-Horimoto K, Sakoda Y, Takashita E, McBride R, Noda T, Hatta M, Imai H, Zhao D, Kishida N, Shirakura M, de Vries RP, Shichinohe S, Okamatsu M, Tamura T, Tomita Y , Fujimoto N, Goto K, Katsura H, Kawakami E, Ishikawa I, Watanabe S, Ito M, Sakai-Tagawa Y, Sugita Y, Uraki R, Yamaji R, Eisfeld AJ, Zhong G, Fan S, Ping J, Maher EA, Hanson A, Uchida Y, Saito T, Ozawa M, Neumann G, Kida H, Odagiri T, Paulson JC, Hasegawa H, Tashiro M, Kawaoka Y
    • Journal Title

      Nature

      Volume: 501(7468) Issue: 7468 Pages: 551-5

    • DOI

      10.1038/nature12392

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013.2013

    • Author(s)
      Kageyama T, Fujisaki S, Takashita E, Xu H, Yamada S, Uchida Y, Neumann G, Saito T, Kawaoka Y, Tashiro M.
    • Journal Title

      Euro Surveillance

      Volume: 18 Pages: 20453-20453

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Attenuation of an influenza A virus due to alteration of its hemagglutinin-neuraminidase functional balance in mice2013

    • Author(s)
      Gen F, Yamada S, Kato K, Akashi H, Kawaoka Y, Horimoto T
    • Journal Title

      Arch Virol

      Volume: 158 Issue: 5 Pages: 1003-1011

    • DOI

      10.1007/s00705-012-1577-3

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Experimental adaptation of an influenza H5 haemagglutinin confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets2012

    • Author(s)
      M. Imai, T. Watanabe, M. Hatta, S. C. Das, M. Ozawa, K. Shinya, G. Zhong, A. Hanson, H. Katsura, S. Watanabe, C. Li, E. Kawakami, S. Yamada, M. Kiso, Y. Suzuki, E. A. Maher, G. Neumann, Y. Kawaoka
    • Journal Title

      Nature

      Volume: (電子版) Issue: 7403 Pages: 1-11

    • DOI

      10.1038/nature10831

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic characterization of H5N1 influenza viruses isolated from chickens in Indonesia in 2010.2012

    • Author(s)
      Nidom CA, Yamada S, Nidom RV, Rahmawati K, Alamudi MY, Kholik, Indrasari S, Hayati RS, Iwatsuki Horimoto K, Kawaoka Y
    • Journal Title

      Virus Genes

      Volume: 44(3) Issue: 3 Pages: 459-465

    • DOI

      10.1007/s11262-012-0722-0

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adaptation of a duck influenza A virus in quail2011

    • Author(s)
      Yamada S, Shinya K, Takada A, Ito T, Suzuki T, Suzuki Y, Le QM, Ebina M, Kasai N, Kida H, Horimoto T, Rivailler P, Chen LM, Donis RO, Kawaoka Y
    • Journal Title

      J Virol

      Volume: 86(3) Issue: 3 Pages: 1411-1420

    • DOI

      10.1128/jvi.06100-11

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Genetic characterization of H5N1 influenza viruses isolated in Indonesia from 2010-20122013

    • Author(s)
      Shinya Yamada, CA. Nidom, RV. Nidom, Kadek Rahmawati, Muhamad Y. et.al.
    • Organizer
      Asia-Africa research forum 2013
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Research-status Report
  • [Presentation] Mutations responsible for the efficient replication of H5N1 influenza viruses in normal human epithelial cells.2012

    • Author(s)
      Shinya Yamada, Mai Q. Le, Chairul A. Nidom, Mutsumi Ito,Yuko Sakai-Tagawa, Yasuo Suzuki, and Yoshihiro Kawaoka
    • Organizer
      The American Society for Virology (ASV)
    • Place of Presentation
      Madison(USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Selection of H5N1 influenza Virus PB2 during Replication in Humans

    • Author(s)
      山田晋弥
    • Organizer
      Pelaksanaan Seminar Protemik Vaksin Flu Burung (Seminor of Bird Flu Vaccine and Proteomics)
    • Place of Presentation
      インドネシア、スラバヤ、アイルランガ大学
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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