Study on the chronic inflammation and cell growth transformation induced by gammaherpesvirus infection
| Project/Area Number |
24590550
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
YASUI Teruhito 大阪大学, 微生物病研究所, 准教授 (60283074)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Epstein-Barrウイルス / ウイルス発がん / Latent membrane protein / B細胞 / リンパ腫 / ノックインマウス / 持続感染 / 自己免疫疾患 / Immunoediting / LMP1 / ヘルペスウイルス / 上皮がん / 慢性炎症 / EBV / MHV68 / 胚中心 / リンパ球 / 抗体 / 発がん |
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| Outline of Final Research Achievements |
Epstein-Barr virus (EBV) infects into the 90 % of human being in the world-wide and is thought to a causative agent for some malignancies. Of the EBV-coding genes, Latent membrane protein (LMP) has been known to be involved in the tumorigenesis. Here this study demonstrates that molecular pathogenesis by which both LMP1 and LMP2a expression in B cells gives rise to lymphomagenesis. Depletion of T cells resulted in the development of splenomegaly induced by aberrant B cell growth. In conclusion, this study clearly indicates that T cells is responsible for the regulation of EBV-induced cell growth transformation in vivo.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis.2014
Author(s)
Tada S, Okuno T, Hitoshi Y, Yasui T, Honorat JH, Takata K, Koda T, Shimagami H, Chi-Jing C, Namba A, Sugimoto T, Sakoda S, Mochizuki H, Kikutani H, Nakatsuji Y.
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Journal Title
J Neuroinflammation
Volume: 11
Pages: 179-186
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Morihana T, Goya S, Mizui M, Yasui T, Prasad DV, Kumanogoh A, Tamura M, Shikina T, Maeda Y, Iwamoto Y, Inohara H, Kikutani H.2013
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[Journal Article] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor.2012
Author(s)
Nakahashi-Oda, C., Tahara-Hanaoka, S., Shoji, M., Okoshi, Y., Nakano-Yokomizo, T., Ohkohchi, N., Yasui, T., Kikutani, H., Honda, S., Shibuya, K., Nagata, S. and Shibuya, A.
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Journal Title
J Exp. Med.
Volume: 209
Issue: 8
Pages: 1493-1503
DOI
Related Report
Peer Reviewed
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