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Study on the chronic inflammation and cell growth transformation induced by gammaherpesvirus infection

Research Project

Project/Area Number 24590550
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Virology
Research InstitutionOsaka University

Principal Investigator

YASUI Teruhito  大阪大学, 微生物病研究所, 准教授 (60283074)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsEpstein-Barrウイルス / ウイルス発がん / Latent membrane protein / B細胞 / リンパ腫 / ノックインマウス / 持続感染 / 自己免疫疾患 / Immunoediting / LMP1 / ヘルペスウイルス / 上皮がん / 慢性炎症 / EBV / MHV68 / 胚中心 / リンパ球 / 抗体 / 発がん
Outline of Final Research Achievements

Epstein-Barr virus (EBV) infects into the 90 % of human being in the world-wide and is thought to a causative agent for some malignancies. Of the EBV-coding genes, Latent membrane protein (LMP) has been known to be involved in the tumorigenesis. Here this study demonstrates that molecular pathogenesis by which both LMP1 and LMP2a expression in B cells gives rise to lymphomagenesis. Depletion of T cells resulted in the development of splenomegaly induced by aberrant B cell growth. In conclusion, this study clearly indicates that T cells is responsible for the regulation of EBV-induced cell growth transformation in vivo.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (33 results)

All 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 1 results) Presentation (27 results) (of which Invited: 1 results)

  • [Journal Article] Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis.2014

    • Author(s)
      Tada S, Okuno T, Hitoshi Y, Yasui T, Honorat JH, Takata K, Koda T, Shimagami H, Chi-Jing C, Namba A, Sugimoto T, Sakoda S, Mochizuki H, Kikutani H, Nakatsuji Y.
    • Journal Title

      J Neuroinflammation

      Volume: 11 Pages: 179-186

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] BAFF controls neural cell survival through BAFF receptor.2013

    • Author(s)
      Tada S, Yasui T, Nakatsuji Y, Okuno T, Koda T, Mochizuki H, Sakoda S, Kikutani H
    • Journal Title

      PLoS One.

      Volume: 29;8(7) Issue: 7 Pages: e70924-e70924

    • DOI

      10.1371/journal.pone.0070924

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significance of GPI-anchored protein enrichment in lipid rafts for the control of autoimmunity2013

    • Author(s)
      Wang, Y., Y. Murakami, T. Yasui, S. Wakana, H. Kikutani, T. Kinoshita and Y. Maeda
    • Journal Title

      J. Biol. Chem

      Volume: 288 Issue: 35 Pages: 25490-25499

    • DOI

      10.1074/jbc.m113.492611

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Morihana T, Goya S, Mizui M, Yasui T, Prasad DV, Kumanogoh A, Tamura M, Shikina T, Maeda Y, Iwamoto Y, Inohara H, Kikutani H.2013

    • Author(s)
      An inhibitory role for Sema4A in antigen-specific allergic asthma
    • Journal Title

      J Clin Immunol.

      Volume: 33(1) Issue: 1 Pages: 200-9

    • DOI

      10.1007/s10875-012-9798-5

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation2012

    • Author(s)
      Yasui T, Sakakibara-Yada K, Nishimura T, Morita K, Tada S, Mosialos G, Kieff E, Kikutani H
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 109(51) Issue: 51 Pages: 21022-7

    • DOI

      10.1073/pnas.1218925110

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor.2012

    • Author(s)
      Nakahashi-Oda, C., Tahara-Hanaoka, S., Shoji, M., Okoshi, Y., Nakano-Yokomizo, T., Ohkohchi, N., Yasui, T., Kikutani, H., Honda, S., Shibuya, K., Nagata, S. and Shibuya, A.
    • Journal Title

      J Exp. Med.

      Volume: 209 Issue: 8 Pages: 1493-1503

    • DOI

      10.1084/jem.20120096

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Averrant activation of Akt in antigen-committed B cells results in selective IgA deficiency2014

    • Author(s)
      Minamitani T,Sakakibara S, Tsai Chau-Yuang, Kikutani H, Yasui T
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Generation and evolution of autoreactive B cells in systemic lupus erythematosus patients2014

    • Author(s)
      Sakakibara S, Takeda K, Yasui T, Kikutani H
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] EBV LMP1/LMP2a誘発B細胞不死化過程における宿主Immunoediting制御2014

    • Author(s)
      安居輝人、南谷武春、Chiau-Yuang Tsai、菊谷仁
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Generation and evolution of autoreactive B cells in systemic lupus erythematosus2014

    • Author(s)
      Sakakibara S, Takeda T, Jinzai H, Yasui T, Kikutani H
    • Organizer
      The 13th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Nara, Japan
    • Year and Date
      2014-09-23 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Epstein-Barr virus LMP2a accelerates B cell survival and plasma cell differentiation in germinal centers2014

    • Author(s)
      Minamitani T, Yasui T, Tsai CY,sakakibara S, Kikutani H
    • Organizer
      The 39th International Herpesvirus workshop
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2014-07-19 – 2014-07-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] EBウイルス LMP1/LMP2a誘導性Bリンパ腫形成とCancer Immunoediting制御2014

    • Author(s)
      安居輝人、南谷武春、Chiau-Yuang Tsai、菊谷仁
    • Organizer
      第11回EBウイルス研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] プロスタグランジン12アゴニストであるONO‐1301はALSモデル動物の神経変性を抑制する2014

    • Author(s)
      多田智、奥野龍禎、安居輝人、中辻裕司、酒井芳紀、宮川繁、菊谷仁、佐古田三郎、望月秀樹
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] EBV LMP2a reduces the stringency of B cell selection in germinal centers.2014

    • Author(s)
      Yasui, T., T. Minamitani, C.-Y. Tsai, S. Sakakibara, M. Busslinger, E. Kieff, and H. Kikutani
    • Organizer
      EBV 50th Anniversary 2014
    • Place of Presentation
      オックスフォーオド大学(イギリス)
    • Related Report
      2013 Research-status Report
  • [Presentation] Direct and indirect inhibition of germinal cnter formation and humoral immune responses by Epstein-Barr virus LMP1.2013

    • Author(s)
      Tsai, C.-Y., T. Yasui, T. Minamitani, S. Sakakibara, and H. Kikutani
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Epstein-Barr virus LMP2a reduces the stringency of B cell selection in germinal center by augmenting BCR signal strength and enhancing plasma cell differentiation.2013

    • Author(s)
      Minamitani, T., T. Yasui, S. Sakakibara, C.-Y. Tsai, and H. Kikutani
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Generation of polyreactive B cells during murine herpesvirus infection.2013

    • Author(s)
      Sakakibara, S., T. Yasui, T. Minamitani, and H. Kikutani
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Signal-cell biology技術を用いたヒト抗HSV1抗体の単離‐持続感染ウイルスに対するヒト液性免疫応答の推移2013

    • Author(s)
      安居輝人、渡部明子、榊原修平、義江修、菊谷仁
    • Organizer
      第61回日本ウイルス学会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Epstein-Barr virus-encoded latent membrane protein 2A impairs B cell selection in germinal centers but not germinal center formation.2013

    • Author(s)
      Minamitani, T., S. Sakakibara, T. Yasui, and H. Kikutani
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milano Congressi (ミラノ市、イタリア)
    • Related Report
      2013 Research-status Report
  • [Presentation] Generation of autoreactive and poly-reactive antibody producing cells during gamma-herpevirus infection.2013

    • Author(s)
      Sakakibara, S., T. Yasui, T. Minamitani, H. Jinzai, and H. Kikutani
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milano Congressi (ミラノ市、イタリア)
    • Related Report
      2013 Research-status Report
  • [Presentation] Inhibition of germinal center formation and humoral immune responses by EB virus protein LMP1.2013

    • Author(s)
      Tsai, C.-Y., T.Yasui, T. Minamitani, K. Morita, S. Sakakibara, and H. Kikutani
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milano Congressi (ミラノ市、イタリア)
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒトHSV1 gD抗体の作成2013

    • Author(s)
      安居輝人、渡部明子、榊原修平、義江修、菊谷仁
    • Organizer
      第28回ヘルペスウイルス研究会
    • Place of Presentation
      淡路夢舞台国際会議場(淡路市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Inhibition of germinal center formation and humoral immune responses by EB virus protein LMP12012

    • Author(s)
      Chiau-Yuang Tsai
    • Organizer
      第41回日本免疫学会
    • Place of Presentation
      神戸市
    • Related Report
      2012 Research-status Report
  • [Presentation] Epstein-barr virus LMP2a affects affinity maturation but not germina.2012

    • Author(s)
      Minamitan, T.
    • Organizer
      第41回日本免疫学会
    • Place of Presentation
      神戸市
    • Related Report
      2012 Research-status Report
  • [Presentation] Generation and selection of virus- and self-reactive B cells during herpesvirus infection.2012

    • Author(s)
      Sakakibara, S.
    • Organizer
      第41回日本免疫学会
    • Place of Presentation
      神戸市
    • Related Report
      2012 Research-status Report
  • [Presentation] Population analysis of effector CD4+ T cells in MHV68 infection by single cell-based RT-PCR.2012

    • Author(s)
      Morita, K.
    • Organizer
      第41回日本免疫学会
    • Place of Presentation
      神戸市
    • Related Report
      2012 Research-status Report
  • [Presentation] ガンマヘルペスウイルス感染による自己抗原産生。2012

    • Author(s)
      榊原修平
    • Organizer
      第60回日本ウイルス学会
    • Place of Presentation
      大阪市
    • Related Report
      2012 Research-status Report
  • [Presentation] Pathogenic activation and evasion of humoral immune responses by γ-herpesvirus infection.2012

    • Author(s)
      Yasui, T.
    • Organizer
      The 11th Awaji International Forum on Infection and Immunity.
    • Place of Presentation
      兵庫県淡路市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Population analysis of effector CD4+ T cells in MHV68 infection by single cell-based RT-PCR.2012

    • Author(s)
      Morita, K.
    • Organizer
      The 11th Awaji International Forum on Infection and Immunity.
    • Place of Presentation
      兵庫県淡路市
    • Related Report
      2012 Research-status Report
  • [Presentation] Generation of virus-and self-reactive B cells during herpesvirus infection.2012

    • Author(s)
      Sakakibara, S.
    • Organizer
      The 11th Awaji International Forum on Infection and Immunity.
    • Place of Presentation
      兵庫県淡路市
    • Related Report
      2012 Research-status Report
  • [Presentation] Expression of EB virus LMP2a modifies the selection of B cells in germinal center.2012

    • Author(s)
      Minamitani, T.
    • Organizer
      International Congress on Oncogenic Herpesviruses and Associated Diseases.
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] EBウイルスLMP1は関連腫瘍発生の必要十分分子となり得るか?-胚中心B細胞特異的LMP1発現マウスの解析。2012

    • Author(s)
      安居輝人
    • Organizer
      第27回ヘルペスウイルス研究会
    • Place of Presentation
      愛知県知多郡東浦町
    • Related Report
      2012 Research-status Report
  • [Presentation] EBウイルス関連腫瘍の発症メカニズム‐胚中心B細胞特異的LMP1発現マウスの解析

    • Author(s)
      安居輝人
    • Organizer
      第9回EBウイルス研究会
    • Place of Presentation
      米子市
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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