| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Outline of Final Research Achievements |
A candidate host factor which may contribute to alter the mutation rate of the virus polymerase was explored in the early experiment. As a series of the experiments, virus factor which may affect mutation rate was sought by comparing a pair viruses derived from the same lineage. These viruses showed a different tendency of mutation under certain environment of selective pressure. With the aim of discovering the genetic predisposition, we conducted Next-generation DNA sequencing against them and plotted the gene mutation. Currently we are comparing these ascertained mutation genes with gene sequences in the database.
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