Defensive mechanism of interferon-regulatory factors (IRFs) via trypsinogens against virus infection.
| Project/Area Number |
24590555
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
HAYASHI Hideki 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (10218589)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUBO Yoshinao 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (30273527)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MATSUYAMA Toshifumi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (30165922)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | インフルエンザウイルス / トリプシノーゲン / エンテロキナーゼ / インターフェロン調節因子(IRFs) / インターフェロン誘導遺伝子(ISGs) / インターフェロン誘導遺伝子 / インターフェロン調節因子 / インターフェロン調節因子IRFs / トリプシノーゲン遺伝子 / A型インフルエンザ・ウイルス / インターフェロン誘導遺伝子ISGs / A型インフルエンザウイルス |
|---|
| Outline of Final Research Achievements |
We have shown the expressions of enterokinase in many human cells other than duodenal cells where it activates trypsinogens secreted from the pancreas. In addition, some types of trypsinogens are reported to exist in many cells as well as pancreatic cells. Our data indicated that the enterokinase significantly enhanced the influenza A virus infection by activating the trypsinogens. The enterokinase-mediated activation of trypsinogens could be a target for the development of new anti-viral reagents against influenza A virus.
|
Report
(4 results)
Research Products
(12 results)
-
-
[Journal Article] Susceptibility of muridae cell lines to ecotropic murine leukemia virus and the cationic amino acid transporter 1 viral receptor sequences: implications for evolution of the viral receptor.2014
Author(s)
Kakoki K, Shinohara A, Izumida M, Koizumi Y, Honda E, Kato G, Igawa T, Sakai H, Hayashi H, Matsuyama T, Morita T, Koshimoto C, Kubo Y.
-
Journal Title
Virus Genes.
Volume: 48
Issue: 3
Pages: 448-456
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] CXCR4-tropic, but not CCR5-tropic, human immunodeficiency virus infection is inhibited by the lipid raft-associated factors, acyclic retinoid analogs, and cholera toxin B subunit2013
Author(s)
H. Kamiyama, K. Kakoki, S. Shigematsu, M. Izumida, Y. Yashima, Y. Tanaka, H. Hayashi, T. Matsuyama, H. Sato, N. Yamamoto, T. Sano, Y. Shidoji, Y. Kubo
-
Journal Title
AIDS Res.Hum.Retrovir.
Volume: 29
Issue: 2
Pages: 279-88
DOI
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
