Analysis of chronic inflammation caused by HTLV-1 infection and development of novel strategies to prevent HTLV-1 associated diseases.
Project/Area Number |
24590556
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Virology
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Research Institution | Kawasaki Medical School |
Principal Investigator |
SAITO Mineki 川崎医科大学, 医学部, 教授 (40398285)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | HTLV-1 / HBZ / 慢性炎症 / 感染防御 / ワクチン |
Outline of Final Research Achievements |
In this study, we have developed novel monoclonal antibodies (mAbs) against HBZ, and established novel ELISA system that allow the quantitative analysis of HBZ protein. Using this newly developed ELISA, we successfully detect and quantified the HBZ protein in HTLV-1 infected T cell lines as well as ATL cells from patients. Meanwhile, we have established a simple humanized mouse model of HTLV-1 infection for evaluating prophylactic and therapeutic interventions. Using this model, we found that neutralizing mAbs specific to HTLV-1 Env gp46 as well as human IgG isolated from HAM patients completely blocked the HTLV-1 infection in vivo, indicating that the neutralizing function of the antibody is essential for preventing the in vivo transmission of HTLV-1.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Increased expression of OX40 is associated with progressive disease in patients with HTLV-1- associated myelopathy/tropical spastic paraparesis.2013
Author(s)
Saito M, Tanaka R, Arishima S, Matsuzaki T, Ishihara S, Tokashiki T, Ohya Y, Takashima H, Umehara F, Izumo S, Tanaka Y.
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Journal Title
Retrovirology
Volume: 10
Issue: 1
Pages: 51-51
DOI
Related Report
Peer Reviewed
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