Characterization of cellular phenotypes specific for the ATL development in HTLV-1 infected humanized mouse
| Project/Area Number |
24590562
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ウイルス / ATL / 動物モデル / HTLV-1 / ヒト化マウス / CD25 / マウスモデル |
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| Outline of Final Research Achievements |
Tumorigenesity of CD25-negative and -positive CD4 T cells isolated from HTLV-1-infected humanized mice that exhibit ATL-like symptoms was examined by transplanting cells to the spleen of NOG mouse and only CD25-positive HTLV-1-infected CD4 T cells was found to form tumor. cDNA microarray analysis demonstrated that several genes related to the regulatory T-cells and a cellular mutator gene, APOBEC3B, were activated upon HTLV-1 infection. Genes for BATF3 and SYK were upregulated in parallel with the expression of CD25. Since no sign of mutation in the level of host genome was detected, the epigenetic modifications are suggested to be mainly involved in the leukemogenesis of HTLV-1 infected humanized mouse.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] A novel HSP90 inhibitor, 17-DMAG, induces Tax down-regulation and its oral administration to ATL-model mice intervenes against the infiltration property of the ATL-like lymphocytes and provides extended survival period2014
Author(s)
Ikebe E, Kawaguchi A, Tezuka K, Taguchi S, Hirose S, Matsumoto T, Mitsui T, Senba K, Nishizono A, Hori M, Hasegawa H, Yamada Y, Ueno T, Tanaka Y, Sawa H, Hall W, Minami Y, Jeang K-T, Ogata M, Morishita K, Hasegawa H, Fujisawa J, Iha H
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Journal Title
Retrovirology
Volume: 11(Suppl1)
Issue: S1
Pages: 44-44
DOI
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[Presentation] Mouse model of ATL2014
Author(s)
Fujisawa J-i, Tanaka M, Ueno T, Xun R, Yao J, Lee S-il
Organizer
第73回日本癌学会学術総会
Place of Presentation
パシフィコ横浜（横浜）
Year and Date
2014-09-25 – 2014-09-27
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