Functional analysis of neurite outgrowth inhibitor proteins in B cell activation
| Project/Area Number |
24590572
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Tohoku University |
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Principal Investigator |
INUI Masanori 東北大学, 加齢医学研究所, 講師 (80443985)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | B細胞 / 免疫寛容 / TLR / 自己寛容 / 免疫制御 / 自己免疫疾患 |
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| Outline of Final Research Achievements |
In this study, I examined the physiological roles of neurite outgrowth inhibitor protein Nogo and Nogo receptor (NgR1) in B cell activation. Nogo-deficient B cells showed a significant reduction of IL-6 and IgM production in response to LPS, CpG and poly(I:C). Thus, Nogo was indispensable for full activation of nucleic acid-sensing TLR responses in B cells.
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Report
(4 results)
Research Products
(16 results)
