| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We found that soluble MD-1 was produced in white adipose tissue (WAT) from high-fat diet (HFD)-fed mice. To investigate roles of soluble MD-1, we generated MD-1 transgenic (Tg) mice that produced large amount of soluble MD-1 in sera. However, no significant differences between wild-type and MD-1 Tg mice were found in body weights, adipose tissue inflammation, and insulin resistance on a HFD.
We also demonstrated that isoliquiritigenin, a component of Glycyrrhiza uralensis, suppressed the expression of RP105/MD-1 and inflammatory cytokines. In vivo analyses revealed that supplementation of isoliquiritigenin inhibited HFD-induced inflammatory responses and IL-1β production in WAT, obesity, and insulin resistance.
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