Search for innate immune molecules and compounds that regulate adipose tissue inflammation
| Project/Area Number |
24590577
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | University of Toyama |
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Principal Investigator |
NAGAI Yoshinori 富山大学, 大学院医学薬学研究部(医学), 客員准教授 (30431761)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 免疫学 / 自然免疫 / 肥満 / 天然薬物 |
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| Outline of Final Research Achievements |
We found that soluble MD-1 was produced in white adipose tissue (WAT) from high-fat diet (HFD)-fed mice. To investigate roles of soluble MD-1, we generated MD-1 transgenic (Tg) mice that produced large amount of soluble MD-1 in sera. However, no significant differences between wild-type and MD-1 Tg mice were found in body weights, adipose tissue inflammation, and insulin resistance on a HFD.
We also demonstrated that isoliquiritigenin, a component of Glycyrrhiza uralensis, suppressed the expression of RP105/MD-1 and inflammatory cytokines. In vivo analyses revealed that supplementation of isoliquiritigenin inhibited HFD-induced inflammatory responses and IL-1β production in WAT, obesity, and insulin resistance.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Increased production of intestinal immunoglobulins in Syntenin-1-deficient mice.2015
Author(s)
Tamura K., Ikutani M., Yoshida T., Tanaka-Hayashi A., Yanagibashi T., Inoue R., Nagai Y., Adachi Y., Miyawaki T., Takatsu K., Mori H.
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Journal Title
Immunobiology
Volume: 220
Issue: 5
Pages: 597-604
DOI
Related Report
Peer Reviewed
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[Journal Article] Inflammation-induced endothelial cell-derived extracellukar vesicles modulate the cellular status of pericytes.2015
Author(s)
Yamamoto S., Niida S., Azuma E., Yanagibashi T., Muramatsu M., Huang TT., Sagara H., Higaki S., Ikutani M., Nagai Y., Takatsu K., Miyazaki K., Hamashima T., Mori H., Matsuda N., Ishii Y., Sasahara M.
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 8505-8505
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Deficiency of nicotinamide mononucleotide adenylyltransferase 3 (nmnat3) causes Hemolytic anemia by altering the glycolytic flow in mature erythrocytes.2014
Author(s)
Hikosaka K., Ikutani M., Shito M., Kazuma K., Gulshan M., Nagai Y., Takatsu K., Konno K., Tobe K., Kanno H., Nakagawa T.
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Journal Title
Journal of Biological Chemistry
Volume: 289
Issue: 21
Pages: 14796-14811
DOI
Related Report
Peer Reviewed
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[Journal Article] Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation.2014
Author(s)
Honda H., Nagai Y., Matsunaga T., Okamoto N., Watanabe Y., Tsuneyama K., Hayashi H., Fujii I., Ikutani M., Hirai Y., Muraguchi A., Takatsu K.
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Journal Title
Journal of Leukocyte Biology
Volume: 96
Issue: 6
Pages: 1087-1100
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Adipose Tissue Hypoxia Induces Inflammatory M1 Polarity of Macrophages in HIF-1a-Dependent and HIF-1a-Independent Manners in Obese Mice.2013
Author(s)
Fujisaka S, Usui I, Ikutani M, Aminuddin A, Takikawa A, Tsuneyama K, Mahmood A, Goda N, Nagai Y, Takatsu K, Tobe K..
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Journal Title
Diabetologia
Volume: 56(6)
Issue: 6
Pages: 1403-1412
DOI
Related Report
Peer Reviewed
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