Aberrant activation of interns in the pathogenesis of immune diseases
| Project/Area Number |
24590579
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Mie University |
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Principal Investigator |
SHIMAOKA Motomu 三重大学, 医学(系)研究科(研究院), 教授 (40281133)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Takayuki 三重大学, 大学院医学系研究科, 助教 (30378286)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 免疫 / 炎症 / 接着分子 / 細胞接着・炎症 / ケモカイン / アレルギー / ショック |
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| Outline of Final Research Achievements |
The unique feature of integrins is the ability to dynamically enhance affinity to bind ligands in opposing cells under shear stress. This study aimed to investigate how the aberrantly regulated integrin activation would affect leukocyte trafficking to inflamed tissues as well as how integrins cooperate with signaling elicited from other receptors such as connexins.
The results obtained in this investigation have provided a framework for better understanding of integrin activation in inflammatory disorders and a potential platform technology to mitigate tissue injury resulting from sustained integrin activation seen in chronic inflammation.
A few review papers published here would facilitate better public understanding of translational medicine and the critical importance of biomedical research.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease, emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory diseases.2014
Author(s)
Yamanaka K, Nakanishi T, Saito H, Maruyama J, Isoda K, Yokochi A, Imanaka-Yoshida K, Tsuda K, Shimaoka M, Mizutoni H, et al.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function- associated antigen 1 (LFA-1) antagonists.2014
Author(s)
Kollmann CS, Bai X, Tsai CH, Yang H, Lind KE, Skinner SR, Zhu Z, Israel DI, Shimaoka M, Evindar G, et al.
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Journal Title
Bioorg Med Chem
Volume: 22
Issue: 7
Pages: 2353-2365
DOI
Related Report
Peer Reviewed
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