Analyses of interaction between IL-18-induced helper NK cells and cytotoxic gamma delta T cells
| Project/Area Number |
24590581
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Nagasaki University |
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Principal Investigator |
TANAKA Yoshimasa 長崎大学, 医歯(薬)学総合研究科(薬学系), 准教授 (90280700)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | γδ型T細胞 / ブチロフィリン / 抗原 / イソペンテニルピロリン酸 / IL-18 / NK細胞 / T細胞受容体 / ブチロフィリン3A1 / 免疫療法 / 抗体 / 乳がん / HTLV-1 / 成人T細胞白血病 / 肺がん / ヘルパーNK細胞 / がん / 細胞療法 / IL-2 |
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| Outline of Final Research Achievements |
It was demonstrated that butyrophilin 3A1 played a critical role in the recognition by human gamma delta T cells of specific antigens. The present study suggests that a change in the structure of extracellular domain of butyrophilin 3A1 induced by binding of intracellularly accumulated isopentenyl diphosphate to intracellular domain of butyrophilin 3A1 is recognized by the human gamma delta T cell receptor. This finding argues that alternative systems of specific T cell recognition, complementing those for major histocompatibility complex-involved peptide antigen recognition by alpha beta T cells, exist for nonpeptide antigen-recognition by human gamma delta T cells.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Effects of zoledronic acid and the association between its efficacy and \gamma\delta T cells in postmenopausal women with breast cancer treated with preoperative hormonal therapy: a study protocol2014
Author(s)
Sumi E, Sugie T, Yoshimura K, Tada H, Ikeda T, Suzuki E, Tanaka Y, Teramukai S, Shimizu A, Toi M, Minato N
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Journal Title
Journal of Translational Medicine
Volume: 12
Issue: 1
Pages: 310-310
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Decreased Vg2Vd2 T cells associate with liver damage through regulating Th17 response in chronic hepatitis B patients2013
Author(s)
Xiaoli Wu, Ji-Yuan Zhang, Ang Huang, Yuan-Yuan Li, Song Zhang, Jun Wei, Siyuan Xia, Yajuan Wan, Weiwei Chen, Zheng Zhang, Yangguang Li, Ti Wen, Yan Chen, Yoshimasa Tanaka, Youjia Cao, Puyue Wang, Liqing Zhao, Zhenzhou Wu, Zheng Zhang, Fu-Sheng Wang, and Zhinan Yin
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Journal Title
J. Infect. Dis.
Volume: 208
Issue: 8
Pages: 1294-1304
DOI
Related Report
Peer Reviewed
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[Journal Article] Comparative analysis of gamma-delta T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid2013
Author(s)
Idrees, AM., Sugie, T., Inoue, C., Murata-Hirai, K., Okamura, H., Morita, CT. Minato, N., Toi, M., Tanaka, Y
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Journal Title
Cancer Science
Volume: (印刷中)
Issue: 5
Pages: 536-542
DOI
Related Report
Peer Reviewed
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[Journal Article] Zoledronic acid-induced expansion of γ δT cells from early-stage breast cancer patients : effect of IL-18 on helper NK cells2013
Author(s)
Sugie, T., Murata-Hirai, K., Iwasaki, M., Morita, C. T., Li, W., Okamura, H., Minato, N., Toi, M., Tanaka, Y.
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Journal Title
Cancer Immunol. Immunoth
Volume: (印刷中)
Issue: 4
Pages: 677-87
DOI
Related Report
Peer Reviewed
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[Journal Article] Zoledronate sensitizes neuroblastoma-derived tumor-initiating cells to cytolysis mediated by human gammadelta T cells2012
Author(s)
Nishio N, Fujita M, Tanaka Y, Maki H, Zhang R, Hirosawa T, Demachi-Okamura A, Uemura Y, Taguchi O, Takahashi Y, Kojima S and Kuzushima K.
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Journal Title
J Immunother
Volume: 35(8)
Issue: 8
Pages: 598-606
DOI
Related Report
Peer Reviewed
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[Presentation] Robust induction of gd T cells with anti-myeloma activity by lenalidomide and IPP in combination2013
Author(s)
Takeshi Harada, Cui Qu, Shingen Nakamura, Asuka Oda, Masami Iwasa, Shiro Fujii, Hirokazu Miki, Kumiko Kagawa, Hironobu Shibata, Shuji Ozaki, Yoshimasa Tanaka, Toshio Matsumoto and Masahiro Abe
Organizer
The 4th Japanese Society of Hematology International Meeting 2013
Place of Presentation
Yamatoya-Honten, Matsuyama, Ehime, Japan
Related Report
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[Presentation] Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate recognition by human Vg2Vd2 T cells2013
Author(s)
Craig T. Morita, Olivier Henry, Mark D. Distefano, Yen-Chih Wang, Johanna Raikkonen, Jukka Monkkonen, Yoshimasa Tanaka, and Hong Wang
Organizer
The American Association of Immunologists Annual Meeting 2013
Place of Presentation
Hawaii Convention Center, Honolulu, Hawaii, U.S.A.
Related Report
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