| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
It was demonstrated that butyrophilin 3A1 played a critical role in the recognition by human gamma delta T cells of specific antigens. The present study suggests that a change in the structure of extracellular domain of butyrophilin 3A1 induced by binding of intracellularly accumulated isopentenyl diphosphate to intracellular domain of butyrophilin 3A1 is recognized by the human gamma delta T cell receptor. This finding argues that alternative systems of specific T cell recognition, complementing those for major histocompatibility complex-involved peptide antigen recognition by alpha beta T cells, exist for nonpeptide antigen-recognition by human gamma delta T cells.
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