Characterization of KDEL receptor that regures T cell survival

• Project/Area Number: 24590583
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: Hokkaido University (2014); Osaka University (2012-2013)
• Principal Investigator: KAMIMURA DAISUKE 北海道大学, 遺伝子病制御研究所, 助教 (20391922)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: T細胞 / 細胞ストレス / 恒常性

Outline of Final Research Achievements

T cells are a central player in the acquired immune system, and their numbers are regulated to be constant in vivo. It has been known that the maintenance of this T-cell homeostasis is mediated by survival signals from cytokine IL-7 and T-cell receptor:MHC interactions. In this study, using a mutant mouse line, called T-Red, it is shown that the T-cell homeostasis is established by a balance between the survival signals and a death signal induced by integrated stress responses.

Research Products

• [Journal Article] Temporal expression of growth factors triggered by epiregulin regulates inflammation development. (2015)
  • Author(s): Harada, M., Kamimura, D., Arima, Y., Kohsaka, H., Nakatsuji, Y., Nishida, M., Atsumi, T., Meng, J., Bando, H., Singh, R., Sabharwal, L., Jiang, J. J., Kumai, N., Miyasaka, N., Sakoda, S., Yamauchi-Takihara, K., Ogura, H., Hirano, T. & Murakami, M.
  • Journal Title: J Immunol Volume: 194 Issue: 3 Pages: 1039-1046
  • DOI: 10.4049/jimmunol.1400562
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The reverse-direction method links mass experimental data to human diseases. (2014)
  • Author(s): Ogura, H., Atsumi, T., Bando, H., Sabharwal, L., Yamada, M., Jiang, J. J., Nakamura, A., Arima, Y., Kamimura, D. & Murakami, M
  • Journal Title: Archivum immunologiae et therapiae experimentalis Volume: 62 Issue: 1 Pages: 41-45
  • DOI: 10.1007/s00005-013-0255-9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Gateway Reflex, which is mediated by the inflammation amplifier, directs pathogenic immune cells into the CNS. (2014)
  • Author(s): Sabharwal, L., Kamimura, D., Meng, J., Bando, H., Ogura, H., Nakayama, C., Jiang, J. J., Kumai, N., Suzuki, H., Atsumi, T., Arima, Y. & Murakami, M.
  • Journal Title: Journal of biochemistry Volume: 156 Issue: 6 Pages: 299-304
  • DOI: 10.1093/jb/mvu057
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Early pathological alterations of lower lumber cords detected by ultra-high field MRI in a mouse multiple sclerosis model. (2014)
  • Author(s): Mori, Y, M. Murakami, Y. Arima, D. Zhu, Y. Terayama, Y. Komai, Y. Nakatsuji, D. Kamimura, and Y. Yoshioka
  • Journal Title: Int Immunol. Volume: 26 Issue: 2 Pages: 93-101
  • DOI: 10.1093/intimm/dxt044
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Disease-Association Analysis of an Inflammation-Related Feedback Loop. (2013)
  • Author(s): Murakami M, Harada M, Kamimura D
  • Journal Title: Cell Reports Volume: 3 Issue: 3 Pages: 946-59
  • DOI: 10.1016/j.celrep.2013.01.028
  • Peer Reviewed
• [Journal Article] IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation. (2013)
  • Author(s): Lee J, Nakagiri T
  • Journal Title: International Immunology Volume: 2 Issue: 5 Pages: 319-332
  • DOI: 10.1093/intimm/dxs158
  • Peer Reviewed
• [Journal Article] Autoimmune disorder phenotypes in HVCN1 gene deficient mice. (2013)
  • Author(s): Sasaki M, Tojo A, Okochi Y, Miyawaki N, Kamimura D, Yamaguchi A, Murakami M, Okamura Y.
  • Journal Title: Biochem J Volume: 450 Issue: 2 Pages: 295-301
  • DOI: 10.1042/bj20121188
  • Peer Reviewed
• [Journal Article] The gateway theory : bridging neural and immune interactions in the CNS (2013)
  • Author(s): Kamimura D, Yamada M, Harada M, et al.
  • Journal Title: Frontiers in Neuroscience Volume: 7 Pages: 204-204
  • DOI: 10.3389/fnins.2013.00204
  • Peer Reviewed
• [Presentation] Characterization of T-Red mutant mouse line having reduced naïve T cells (2014)
  • Author(s): 上村大輔
  • Organizer: 第43回日本免疫学会総会
  • Place of Presentation: 国立京都国際会館（京都府、京都市）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Characterization of an ENU mutant mouse line having reduced naïve T cells (2013)
  • Author(s): Daisuke Kamimura, Hideki Ogura, Yasunobu Arima, Lavannya Sabharwal, Moe Yamada, Mineko Tsuruoka, Takanori Hasegawa, Hisahiro Yoshida, Haruhiko Koseki, Toshiyuki Fukada, Toshio Hirano, and Masaaki Murakami
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
• [Presentation] Characterization of an ENU-mutant mouse with impaired T-cell homeostasis (2012)
  • Author(s): Daisuke Kamimura, Jing-jing Jiang, Shunji Mitani, Naoko Ueda, Mineko Tsuruoka, Hisahiro Yoshida, Haruhiko Koseki, Toshiyuki Fukada, Hideki Ogura, and Toshio Hirano, and Masaaki Murakami
  • Organizer: 第４１回日本免疫学会
  • Place of Presentation: 神戸国際会議場
• [Book] Cytokine Frontiers: Regulation of Immune Responses in Health and Disease (2014)
  • Author(s): Kamimura, D., H. Ogura, Y. Arima, T. Hirano, and M. Murakami.
  • Total Pages: 396
  • Publisher: Springer