| Project/Area Number |
24590634
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical sociology
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| Research Institution | Showa University |
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Principal Investigator |
IWASE MARIKO 昭和大学, 医学部, 助教 (70424273)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Yuki 昭和大学, 医学部, 講師 (40276572)
KURATA Norimitsu 昭和大学, 教養部, 教授 (80231299)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 一般用医薬品 / チトクロームP450 / セルフメディケーション / 薬物相互作用 |
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| Outline of Final Research Achievements |
OTC (Over the counter) drugs have been used for a long time period, however, there is a little information concerning to the drug-drug interaction. In the current study, we investigated the inhibitory effects of commonly used OTC drugs on cytochrome P450 (CYP) activities using human liver microsomes. The possibility of the OTC drugs to cause drug interactions with the prescribed drugs in clinical situation were predicted by using the equation recommended by The Ministry of Health, Labour and Welfare. The results showed that among the studied 26 OTC drugs, bromohexine hydrochloride, tipepidine hibenzate and difenidole hydrochloride extensively inhibited CYP2D6 activity, suggested the possibility of drug interaction at the commonly used clinical dosage level. Because these OTC drugs are considered to use concomitantly with various therapeutic agents, the appropriate medication interview to the patients to avoid the risks of adverse reaction.
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