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Research for genetic specificity of the Multi Drug-resistant Mycobacterium tuberculosis Spreading in Osaka Prefecture.

Research Project

Project/Area Number 24590651
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical sociology
Research InstitutionOsaka Prefectural Institute of Public Health

Principal Investigator

TAMARU Aki  大阪府立公衆衛生研究所, その他部局等, 主任研究員 (70270767)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Soukichi  新潟大学, 医学部細菌学教室, 教授 (30244073)
WADA Takayuki  長崎大学, 熱帯医学研究所, 助教 (70332450)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords多剤耐性結核菌 / 遺伝子型別 / ゲノム解析 / SNP解析 / 多剤耐性結核 / SNPs解析
Outline of Final Research Achievements

V02 strain: the spreading multi drug-resistant Mycobacterium tuberculosis stain in Osaka Prefecture, were subjected to genome-wide analysis by next-generation sequencing. Compared with H37Rv, 1,445 SNPs were common to all 15 isolates belonging to V02 strain. Although 51 SNPs were found among 15 isolates of V02 strain, and V02 strains were divided into two groups by two SNPs (A to C at 7582 and G to A at 3157508). These results shows the existence of V02 strains was not from one outbreak causing by one infectious source but the isolates of V02 may have common ancestor.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (6 results)

  • [Journal Article] 1.Direct detection of Mycobacterium avium in environmental water and scale samples by loop-mediated isothermal amplification.2014

    • Author(s)
      Nishiuchi Y, Tamaru A, Suzuki Y, Kitada S, Maekura R, Tateishi Y, Niki M, Ogura H, Matsumoto S
    • Journal Title

      J Water Health.

      Volume: 12 Issue: 2 Pages: 211-219

    • DOI

      10.2166/wh.2013.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ntra-subspecies sequence variability of the MACPPE12 gene in Mycobacterium avium subsp. Hominissuis2014

    • Author(s)
      Iwamoto T, Arikawa K, Nakajima C, Nakanishi N, Nishiuchi Y, Yoshida S, Tamaru A,Tamura Y, Hoshino Y, Yoo H, Park YK, Saito H, Suzuki Y
    • Journal Title

      Infect. Genet. Evolu.

      Volume: 21 Pages: 476-483

    • DOI

      10.1016/j.meegid.2013.08.010

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dominant Incidence of Multidrug and Extensively Drug-Resistant Specific Mycobacterium tuberculosis Clones in Osaka Prefecture, Japan.2012

    • Author(s)
      Tamaru, A., C. Nakajima, T. Wada, Y. Wang, M. Inoue, R. Kawahara, R. Maekura, Y. Ozeki, H. Ogura, K. Kobayashi, Y. Suzuki, and S. Matsumoto.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 8 Pages: e42505-e42505

    • DOI

      10.1371/journal.pone.0042505

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sensitivities of cipofloxacin-resistant Mycobacterium tuberculosis clinical isolates to fluoroquinolones : role of mutant DNA gyrase subunits in drug resistance2012

    • Author(s)
      Y.Suzuki, C.Nakajima, A Tamaru, H.Kim, et al
    • Journal Title

      International Journal of Antimicrobial Agents

      Volume: 39 Issue: 5 Pages: 435-439

    • DOI

      10.1016/j.ijantimicag.2012.01.007

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic diversity of Mycobacterium avium subsp. hominissuis strains isolated from humans, pigs, and human living environment2012

    • Author(s)
      D Iwamoto T, Nakajima C, Nishiuchi Y, Kato T, Yoshida S, Nakanishi N, Tamaru A, Tamura Y, Suzuki Y, Nasu M
    • Journal Title

      Infect. Genet. Evolu

      Volume: Vol.12 Issue: 4 Pages: 846-52

    • DOI

      10.1016/j.meegid.2011.06.018

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 当所における多剤耐性結核菌の発生状況と分子疫学:2007年以降とそれ以前の比較2015

    • Author(s)
      田丸亜貴
    • Organizer
      第90回日本結核学会総会
    • Place of Presentation
      長崎市
    • Year and Date
      2015-03-27 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] コンタミネーションが原因の結核菌検査誤判定例とその対策に関する考察2014

    • Author(s)
      田丸亜貴
    • Organizer
      第73回日本公衆衛生学会総会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高まん延地域の結核対策における分子疫学的解析2013

    • Author(s)
      田丸亜貴
    • Organizer
      日本公衆衛生学会総会
    • Place of Presentation
      三重県津市
    • Related Report
      2013 Research-status Report
  • [Presentation] Comparison of Mycobacterium tuberculosis Genotypes Isolated from Urban and Rural Regions in OSAKA Bay Shore Area in JAPAN.2013

    • Author(s)
      Aki Tamaru, Chie Nakajima and Yasuhiko Suzuki
    • Organizer
      US-JAPAN COOPERATIVE MEDICAL SCIENCE PROGRAM: TUBERCULOSIS AND LEPROSY PANEL MEETING IN JAPAN
    • Place of Presentation
      北海道 札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] 大阪府における多剤耐性結核の分子疫学2012

    • Author(s)
      田丸亜貴
    • Organizer
      第53回日本社会医学会総会
    • Place of Presentation
      大阪府高槻市
    • Related Report
      2012 Research-status Report
  • [Presentation] Outbreak of Mycobacterium bovis Infections of Japanese Shika Deer (Caervus nippon centralis) in Zoological garden in Osaka2012

    • Author(s)
      田丸亜貴、鈴木定彦、中島千恵、郡山孝則、坪田敏雄
    • Organizer
      Asian society for zoo and wildlife medicine society
    • Place of Presentation
      タイ バンコク
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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