Personalized medicine for schizophrenia: developement of PK-PD-PGx model
| Project/Area Number |
24590652
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SARUWATARI Jun 熊本大学, 大学院・医学薬学研究部, 講師 (30543409)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 統合失調症 / 遺伝子 / 薬物動態 / 臨床反応 / メタボリック症候群 / 薬物療法 / GSTK1 / 疾患感受性遺伝子 / 薬物反応性 |
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| Outline of Final Research Achievements |
We focused on an interaction between drug concentration of antipsychotics and receptor gene polymorphism for prediction of drug response in acute schizophrenia receiving resperidone. While there was a positive correction between drug concentration and improvement of positive symptoms in patients with Ins/Ins genotype in -141Ins/Del of DRD2 gene, an inverse correlation between drug concentration and improvement of negative symptoms in patients with Ins/Del or Del/Del was found. On the other hand, the long-term use of the antipsychotic caused side effects such as obesity and impaired glucose tolerance. There was a higher rate of metabolic syndrome in chronic schizophrenia patients with GSTT1 null. In addition, higher prevalence of metabolic syndrome and hypertension was observed in C allele carrier of CLOCK C3111T gene. It is, thus, reasonable to conclude that a combination of drug concentration and genetic information contributes to personalized medicine in schizophrenia.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Pregnane X receptor and hepatocyte nuclear factor 4alpha polymorphisms are cooperatively associated with carbamazepine autoinduction.2014
Author(s)
Saruwatari J, Yoshida S, Tsuda Y, Okada Y, Ogusu N, Yoshida K, Oniki K, Yasui-Furukori N, Kaneko S, Ishitsu T, Nakagawa K.
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Journal Title
Pharmacogenet Genomics
Volume: 24
Issue: 3
Pages: 162-171
DOI
Related Report
Peer Reviewed
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[Journal Article] Possible associations between antioxidant enzyme polymorphisms and metabolic abnormalities in patients with schizophrenia.2013
Author(s)
Saruwatari J, Yasui-Furukori N, Kamihashi R, Yoshimori Y, Oniki K, Tsuchimine S, Noai M, Sato Y, Nakagami T, Sugawara N, Saito M, Fujii A, Kajiwara A, Mihara S, Ogata Y, Kaneko S, Nakagawa K.
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Journal Title
Neuropsychiatr Dis Treat
Volume: 9
Pages: 1683-1698
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of age and disease on bone mass in Japanese patients with schizophrenia.2012
Author(s)
Sugawara N, Yasui-Furukori N, Umeda T, Tsuchimine S, Fujii A, Sato Y, Saito M, Furukori H, Danjo K, Matsuzaka M, Takahashi I, Kaneko S.
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Journal Title
Ann Gen Psychiatry
Volume: 11
Issue: 1
Pages: 5-5
DOI
Related Report
Peer Reviewed
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