• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Biological optimal dosing of anti-neoplastic in order to maximize therapeutic efficacy and safety

Research Project

Project/Area Number 24590656
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied pharmacology
Research InstitutionKyoto University

Principal Investigator

Ishiguro Hiroshi  京都大学, 医学(系)研究科(研究院), 准教授 (20422925)

Co-Investigator(Kenkyū-buntansha) TOI Masakazu  京都大学, 大学院医学研究科, 教授 (10207516)
TERAMUKAI Satoshi  京都府立医科大学, 医学研究科, 教授 (20359798)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsMedical Oncology / Pharamcokinetics / Supportive care / 臨床腫瘍学 / 臨床薬理学 / 薬物動態 / 薬力学 / 支持療法 / 抗悪性腫瘍薬
Outline of Final Research Achievements

For anti-cancer treatment, biologically optimal dosing in addition to state of art supportive care in order to aim for best drug efficacy is very important.
We have conducted several clinical trial aiming for better management for chemotherapy-induced nausea and vomiting, molecular targeted drug-related skin rash, 5HT3-induced constipation and published them at the major scientific conference or journal.
We also conducted clinical trial to find out biologially optimal dosing for anti-anti-neoplastics, such as decetaxel, afatinib irinotecan and TS-1. We also published them at the major scientific conference or journal.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (74 results)

All 2016 2015 2014 2013 2012

All Journal Article (37 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 19 results,  Open Access: 10 results,  Acknowledgement Compliant: 2 results) Presentation (26 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Book (11 results)

  • [Journal Article] Measuring motivation for medical treatment: confirming the factor structure of the Achievement Motivation Index for Medical Treatment (AMI-MeT)2016

    • Author(s)
      Taichi Hatta, Keiichi Narita, Kazuhiro Yanagihara, Hiroshi Ishiguro, Toshinori Murayama and Masayuki Yokode
    • Journal Title

      BMC Medical Informatics and Decision Making

      Volume: 16 Issue: 1 Pages: 22-22

    • DOI

      10.1186/s12911-016-0260-0

    • NAID

      120005758425

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Significant effect of age on docetaxel pharmacokinetics in Japanese female breast cancer patients by using the population modeling approach2016

    • Author(s)
      Onoue H, Yano I, Tanaka A, Itohara K, Hanai A, Ishiguro H, Motohashi H, Masuda S, Matsubara K
    • Journal Title

      Eur J Clin Pharmacol

      Volume: Epub ahead of print

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of a self-management program on antiemetic-induced constipation during chemotherapy among breast cancer patients:a randomized controlled clinical trial2016

    • Author(s)
      Akiko Hanai, Hiroshi Ishiguro, Takashi Sozu, Moe Tsuda, Hidenori Arai, Akira Mitani, Tadao Tsuboyama
    • Journal Title

      Breast Cancer Research and Treatment

      Volume: 155 Issue: 1 Pages: 99-107

    • DOI

      10.1007/s10549-015-3652-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 発熱性好中球減少の予防 up date2016

    • Author(s)
      古武 剛・石黒 洋
    • Journal Title

      CANCER BOAD of the BREAST

      Volume: 2(1) Pages: 47-50

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] 乳がん 標準治療とエビデンス2016

    • Author(s)
      中山美恵、石黒 洋
    • Journal Title

      月刊薬事2016年1月臨時増刊号

      Volume: 58(2) Pages: 61-74

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Phase I trial of afatinib plus in Japanese patients with advanced solid tumors, including breast cancer2015

    • Author(s)
      Mukai H, Masuda N, Ishiguro H, Mitsuma A, Shibata T, Yamamura J, Toi M, Watabe A, Sarashina A, Uttenreuther-Fischer M, Ando Y
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 76(4) Issue: 4 Pages: 739-50

    • DOI

      10.1007/s00280-015-2826-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Developnemt of breast cancer therapy:biomarker-driven and response-guided approaches in a neoadjuvant setting2015

    • Author(s)
      Toi M, Masuda N, Ishiguro H, Saji S, Ohno S, Chow LW.
    • Journal Title

      Int J Biol Markers

      Volume: 30(2)

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 薬物療法マネージメントのこつ 内分泌療法の副作用対策2015

    • Author(s)
      山口絢音、石黒 洋
    • Journal Title

      Cancer Board of the Breast

      Volume: 1(2) Pages: 51-54

    • NAID

      40021086656

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] ラパチニブによる肝障害に関連する遺伝子多型2015

    • Author(s)
      後藤 知之, 石黒 洋
    • Journal Title

      がん分子標的治療

      Volume: 13(1) Pages: 108-112

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 薬物療法マネージメントのこつ 妊孕性温存(fertility preservation)2015

    • Author(s)
      仁尾 万里華, 津田 萌, 石黒 洋
    • Journal Title

      Cancer Board of the Breast

      Volume: 1(1) Pages: 49-52

    • NAID

      40021077357

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] 抗がん剤の副作用と支持療法-より適切な抗がん剤の安全使用をめざして-】 系統別抗がん剤の副作用 内分泌療法薬 内分泌療法薬の作用機序と副作用 概論2015

    • Author(s)
      津田 萌, 石黒 洋, 佐治 重衡
    • Journal Title

      日本臨床

      Volume: 73(増2) Pages: 291-297

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] 【抗がん剤の副作用と支持療法―より適切な抗がん剤の安全使用を目指して―】系統別抗がん剤の副作用分子標的薬 小分子化合物 HER2阻害薬の副作用および支持療法2015

    • Author(s)
      川田有希子、河口浩介、石黒 洋
    • Journal Title

      日本臨床

      Volume: 73(増2) Pages: 240-244

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] がん診療と腫瘍内科医の役割 (特集 がんサバイバーシップ)2015

    • Author(s)
      古武剛,、石黒洋
    • Journal Title

      治療

      Volume: 97(10) Pages: 1347-1350

    • NAID

      40020602920

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] 【分子標的治療を含む併用療法】乳がんに対する分子標的治療と併用療法2015

    • Author(s)
      常盤麻里子、 石黒洋
    • Journal Title

      がん分子標的治療

      Volume: 13(3) Pages: 27-32

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] ラパチニブによる肝障害に関連する遺伝子多型2015

    • Author(s)
      後藤知之、石黒 洋
    • Journal Title

      がん分子標的治療

      Volume: 13 Pages: 108-112

    • Related Report
      2014 Research-status Report
  • [Journal Article] 薬物療法のマネージメントのこつ 妊孕性温存(fertility preservation)2015

    • Author(s)
      仁尾万理華、津田 萌、石黒 洋
    • Journal Title

      CANCER BOARD of the BREAST

      Volume: 1 Pages: 49-52

    • Related Report
      2014 Research-status Report
  • [Journal Article] 【抗がん剤の副作用と支持療法-より適切な抗がん剤の安全使用をめざして-】 系統別抗がん剤の副作用 内分泌療法薬 内分泌療法薬の作用機序と副作用 概論(解説/特集)2015

    • Author(s)
      津田 萌、石黒 洋、佐治重衡
    • Journal Title

      日本臨床

      Volume: 73 Pages: 291-297

    • Related Report
      2014 Research-status Report
  • [Journal Article] 【抗がん剤の副作用と支持療法-より適切な抗がん剤の安全使用をめざして-】系統別抗がん剤の副作用 分子標的薬 小分子化合物 HER2阻害薬の副作用および支持療法(解説/特集)2015

    • Author(s)
      川田有希子、河口浩介、石黒 洋
    • Journal Title

      日本臨床

      Volume: 73 Pages: 240-244

    • Related Report
      2014 Research-status Report
  • [Journal Article] Development of breast cancer therapy:biomarker-driven and response-guided approaches in a neoadjuvant setting2015

    • Author(s)
      Toi M, Masuda M, Ishiguro H, Saji S, Ohno S, Chow LW
    • Journal Title

      Int J Biol Markers

      Volume: 7 Issue: 2 Pages: 252-253

    • DOI

      10.5301/jbm.5000136

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Re:Denosumab for Patients With Persistent or Relapsed Hypercalcemia of Malignancy Despite Recent Bisphosphonate Treatment.2014

    • Author(s)
      Tuda M,Ishiguro H,Yano I,Toi M
    • Journal Title

      J Natl Cancer Inst

      Volume: 106

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevention Of Chemotherapy--Induced Nausea And Vomiting by Olanzapine in Japanese Female patients with Early Breast Cancer who had Poor Control With the Standard Antiemetic Regimen2014

    • Author(s)
      Nishimura T,Ishiguro H,Kawaguchi K,Sugie T,Tokiwa M,Takeuchi M,Toi M
    • Journal Title

      Cancer Stud Open Access

      Volume: 1

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 化学療法 副作用情報室 妊娠期乳癌に対する化学療法2014

    • Author(s)
      津田 萌、石黒 洋
    • Journal Title

      CANCER BOARD 乳癌

      Volume: 7 Pages: 51-54

    • Related Report
      2014 Research-status Report
  • [Journal Article] Survival of HER2-positive primary breast cancer patients treated by neoadjuvant chemotherapy plus trastuzumab: a multicenter retrospective observational study (JBCRG-C03 study).2014

    • Author(s)
      Takada M, Ishiguro H, Nagai S, Ohtani S, Kawabata H, Yanagita Y, Hozumi Y, Shimizu C, Takao S, Sato N, Kosaka Y, Sagara Y, Iwata H, Ohno S, Kuroi K, Masuda N, Yamashiro H, Sugimoto M, Kondo M, Naito Y, Sasano H, Inamato T, Morita S, Toi M on behalf of the JBCRG-C03 Collaborative Group.
    • Journal Title

      Breast Cancer Res Treat

      Volume: Volume 145, Issue 1 Issue: 1 Pages: 143-53

    • DOI

      10.1007/s10549-014-2907-9

    • NAID

      120005627665

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Re: Denosumab for Patients With Persistent or Relapsed Hypercalcemia of Malignancy Despite Recent Bisphosphonate Treatment.2014

    • Author(s)
      Tsuda M, Ishiguro H, Yano I, Toi M.
    • Journal Title

      J Natl Cancer Inst

      Volume: accepted for publication

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Orally Administered S-1 Suppresses Circulating Endothelial Cell Counts in Metastatic Breast Cancer Patients.2013

    • Author(s)
      Tsuji W, Ishiguro H, Tanaka S, Takeuchi M, Ueno T, Toi M.
    • Journal Title

      Int J Clin Oncol

      Volume: Epub ahead of print Issue: 3 Pages: 452-459

    • DOI

      10.1007/s10147-013-0570-5

    • NAID

      120005372985

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Colony-Stimulating Factors for Febrile Neutropenia.2013

    • Author(s)
      Ishiguro H, Toi M.
    • Journal Title

      N Engl J Med

      Volume: Vol.369, No.3 Issue: 3 Pages: 284-6

    • DOI

      10.1056/nejmc1306109

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cross-National Comparison of Medical Costs Shared by Payers and Patients: A Study of Postmenopausal Women with Early-Stage Breast Cancer Based on Assumption Case Scenarios and Reimbursement Fees.2013

    • Author(s)
      Hamada S, Hinotsu S, Ishiguro H, Toi M, Kawakami K.
    • Journal Title

      Breast Care

      Volume: Aug. Vol.8, No.4 Issue: 4 Pages: 282-8

    • DOI

      10.1159/000354249

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 外来化学療法におけるインフォームド・コンセントの観察研究 : 医療に関する達成動機と医師患者のIC主観評価との数量的関係2013

    • Author(s)
      八田太一、成田慶一、柳原一広、石黒洋、岸本寛史、林晶子、村山敏典、横出正之
    • Journal Title

      心身医学

      Volume: 53巻 1号 Pages: 76-76

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] がん薬物療法専門医(腫瘍内科医)になろう!2013

    • Author(s)
      石黒 洋
    • Journal Title

      増刊レジデントノート

      Volume: 15 Pages: 209-215

    • Related Report
      2013 Research-status Report
  • [Journal Article] 乳がんに対する抗体療法2013

    • Author(s)
      岡本奈津子、河口浩介、石黒洋
    • Journal Title

      最新醫學

      Volume: 69 Pages: 93-106

    • Related Report
      2013 Research-status Report
  • [Journal Article] 化学療法 副作用情報室 悪心・嘔吐・食欲不振対策update2013

    • Author(s)
      津田 萌、石黒 洋
    • Journal Title

      Cancer Board 乳癌

      Volume: 6巻1号 Pages: 68-71

    • Related Report
      2013 Research-status Report
  • [Journal Article] 化学療法 副作用情報室 Bone modifying agent(BMA)の副作用対策2013

    • Author(s)
      津田 萌、石黒 洋
    • Journal Title

      Cancer Board 乳癌

      Volume: 6巻2号 Pages: 152-154

    • Related Report
      2013 Research-status Report
  • [Journal Article] FECとAbraxaneの投与が著効した乳癌の1例2013

    • Author(s)
      芳林 浩史, 石黒 洋, 川口 佳奈子, 矢本 真子, 西村 友美, 山田 晴美, 南村 真紀, 西尾 直子, 中村 京平, 嶋田 功太郎, 小野 一雄, 加藤 博明
    • Journal Title

      癌と化学療法

      Volume: 40巻5号 Pages: 627-629

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antipsychotics-containing regimen as an alternative to standard antiemetics for delayed nausea induced by highly emetogenic chemotherapy.2013

    • Author(s)
      Ishiguro H, Kawaguchi K, Nishimura T, Toi M.
    • Journal Title

      J Clin Oncol

      Volume: Vol.31, No.10

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessments of CAD-generated tumor volumes measured using MRI in breast cancers before and after neoadjuvant chemotherapy.2012

    • Author(s)
      Takeda K, Kanao S, Okada T, Kataoka M, Ueno T, Toi M, Ishiguro H, Mikami Y, Togashi K.
    • Journal Title

      Eur J Radiol

      Volume: Vol.81, No.10

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetics and pharmacogenomics of selective estrogen receptor modulators in breast cancer patients.2012

    • Author(s)
      Ishiguro H, Toi M.
    • Journal Title

      Current Topics in Pharmacology

      Volume: Vol.16

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] How to dose cytotoxic chemotherapeutic drugs.2012

    • Author(s)
      Ishiguro H, Toi M.
    • Journal Title

      Current Topics in Pharmacology

      Volume: Vol.16

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Prevention of chemotherapy-induced nausea and vomiting by olanzapine containing antiemetic regimen without aprepitant in Japanese female patients with breast cancer2016

    • Author(s)
      Nishimura T, Ishiguro H, Nakakimura T, Fukui Y, Maekawa K, Nio M, Yamaguchi A, Nakayama Y, Rin S, Kotake T,Yanai S, Matsumoto Y, Takada M, Takeuchi M, Suzuki E,Sato F, Toi M
    • Organizer
      AOS 2016 Kyoto Breast Cancer Consensus Conference 2016(KBCCC)International Conference
    • Place of Presentation
      京都市国際交流会館/ウェスティン都ホテル京都
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The alteration of circulating endothelial progenitor cell counts could be independent predictive factor for pathological response to neoadjuvant chemotherapy in breast cancer patients2016

    • Author(s)
      Tanaka S, Ueno T,Ishiguro H,Toi M
    • Organizer
      AOS 2016 Kyoto Breast Cancer Consensus Conference 2016(KBCCC)International Conference
    • Place of Presentation
      京都市国際交流会館/ウェスティン都ホテル京都
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Significant suppression of serum estradiol concentrations during adjuvant aromatase inhibitor treatment in Japanese patients2016

    • Author(s)
      Tsuda M,IshiguroH, Saji S,Takeuchi M,Suzuki E,Takada M,Sato F, Toi M
    • Organizer
      AOS 2016 Kyoto Breast Cancer Consensus Conference 2016(KBCCC)International Conference
    • Place of Presentation
      京都市国際交流会館/ウェスティン都ホテル京都
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cisplatin based preoperative chemotherapy regimens have the potential to improve prognosis whether patients achieved pCR or not :A retrospective analysis from single-institution2016

    • Author(s)
      Yamaguchi A, Ishiguro H, Torii M,Takada M, Suzuki E,Takeuchi M, Sato F, Toi M
    • Organizer
      AOS 2016 Kyoto Breast Cancer Consensus Conference 2016(KBCCC)International Conference
    • Place of Presentation
      京都市国際交流会館/ウェスティン都ホテル京都
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pharmacogenomicspharmacokinetics study of selective estrogen-receptor modulators with intra-patient dose escalation for Japanese breast cancer patients2015

    • Author(s)
      Ohno S,Ishiguro H,Yamamoto Y,Takao S,Sato N,Fujisawa T,Kadoya T ,Kuroi K,Bando H,Teramura Y,Iwata H,Tanaka S,Toi M,
    • Organizer
      SAN ANTONIO BREAST CANCER SYMPOSIUM
    • Place of Presentation
      San Antonio, Texas
    • Year and Date
      2015-12-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がん医療における生存期間中央値の伝えられ方 (1) - 当意即妙を捉える方法論 - (2) - 当意即妙が機能する事例 -2015

    • Author(s)
      八田太一, 成田慶一, 三田村仰, 柳原一広, 石黒洋, 村山敏典, 横出正之
    • Organizer
      第57回日本身心医学会近畿地方会
    • Place of Presentation
      大阪大学中之島センター
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] HER2陽性乳癌における術前トラスツマブ+抗癌薬併用療法後の治療効果を予測する数理モデルの開発2015

    • Author(s)
      高田正泰、杉本昌弘、増田慎三、岩田広浩、黒井克昌、山城大泰、大野信真司、石黒洋、稲本俊、戸井雅和
    • Organizer
      第13回日本臨床腫瘍学会学術集会
    • Place of Presentation
      ロイトン札幌/ホテル札幌芸文館
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 化学療法抵抗性trinple negative 乳癌患者におけるシスプラチン併用時のエリブリン投与量斬新的漸増法の検討2015

    • Author(s)
      山口絢音、石黒洋、高田正泰、川島雅央、鳥井雅恵、戸井雅和
    • Organizer
      第13回日本臨床腫瘍学会学術集会
    • Place of Presentation
      ロイトン札幌/ホテル札幌芸文館
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] HER2陽性乳癌における術前Dual-HER2blockage療法±ホルモン療法の検討(Neo-LaTH,JBCRG-16試験)2015

    • Author(s)
      山本尚人、増田慎三、近藤直人、坂東裕子、黒井克昌、大野真司、宮本健志、檜垣健二、高野利実、井上賢一、中村力也、清水哲、石黒洋、青儀健二郎、天野定雄、山城大泰、笠井宏委、森田智視、桜井孝規、戸井雅和
    • Organizer
      第23回日本乳癌学会学術総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2015-07-02 – 2015-07-04
    • Related Report
      2014 Research-status Report
  • [Presentation] HER2陽性乳癌における術前Dual-HER2blockage両方±ホルモン療法の検討(Neo-LaTH,JBCRG-16試験)2015

    • Author(s)
      山本尚人、増田慎三、 近藤直人、 坂東裕子、 黒井克昌、 大野真司、 宮本健志、 檜垣健二、 高野利実、 井上賢一、 中村力也、 清水哲、 石黒洋、 青儀健二郎、 天野定雄、 山城大泰、 笠井宏委、 森田智視、 桜井孝規、 戸井雅和
    • Organizer
      第23回日本乳癌学会学術総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] pCRの意義を問う HER2陽性乳癌における術前Dual-HER2 blockage療法±ホルモン療法の検討(Neo-LaTH、JBCRG-16試験)2015

    • Author(s)
      山本尚人、増田慎三、 近藤直人、 坂東裕子、 黒井克昌、 大野真司、 宮本健志、 檜垣健二、 高野利実、 井上賢一、 中村力也、 清水哲、 石黒洋、 青儀健二郎、 天野定雄、 山城大泰、 笠井宏委、 森田智視、 桜井孝規、 戸井雅和
    • Organizer
      第23回日本乳癌学会学術総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of a self-exercise program on serotonin antagonist-induced constipation during chemotherapy in breast cancer patients: a randomized, controlled pilot trial2015

    • Author(s)
      A.Hanai, H. Ishiguro, T.Sozu, M.Tsuda, H Arai, A.Mitani, T.Tsuboyama
    • Organizer
      The 3rd International Symposium of Training Plan for Oncology Professionals
    • Place of Presentation
      Sheraton Miyako Hotel Osaka
    • Year and Date
      2015-02-07 – 2015-02-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Early response to neoadjuvant chemotherapy in breast cancer:MR Imaging for prediction of pCR2014

    • Author(s)
      津田 萌、高田正泰、杉江知治、金尾昌太郎、三上芳喜、上野貴之、竹内 恵、鈴木栄治、石黒 洋、戸井雅和
    • Organizer
      第12回日本臨床腫瘍学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-07-17 – 2014-07-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Optimal dosing of selective estrogen receptor modulators for breast cancer patients (Invited speaker)2014

    • Author(s)
      Ishiguro H.
    • Organizer
      Seoul-Kyoto Breast Cancer Education Seminar
    • Place of Presentation
      Seoul, South Korea
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 基底様(basal-like)乳癌における術前化学療法の検討2013

    • Author(s)
      鳥井 雅恵、石黒 洋、高田 正泰 、杉江 知治 、鈴木 栄治 、 竹内 恵 、上野 貴之 、金尾 昌太郎 、三上 芳喜 、戸井 雅和
    • Organizer
      第21回日本乳癌学会学術総会
    • Place of Presentation
      浜松
    • Related Report
      2013 Research-status Report
  • [Presentation] Dramatic and durable response to denosumab for humoral hypercalsemia of malignancy refractory to weekly zoledronic acid.2013

    • Author(s)
      Tsuda M, Ishiguro H, Sugie T, Yasoda A, Toi M.
    • Organizer
      Multinational Association of Supportive Care in Cancer (MASCC)
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Research-status Report
  • [Presentation] Determining possible cardiotoxicity risk modifiers (ACEI, beta-blockers, and G-CSF) in breast cancer patients receiving anthracycline and trastuzumab: a case-control study2013

    • Author(s)
      Namura M, Ishiguro H, Yamagami K, Abe H, Tsuyuki S, Yamauchi A, Inamoto T, Kan N, Yoshibayashi H, Suwa H, Ichinose Y, Kato H, Shinkura N, Toi M.
    • Organizer
      Multinational Association of Supportive Care in Cancer (MASCC)
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Research-status Report
  • [Presentation] Dramatic and durable response to denosumab given for humoral hypercalcemia with malignancy refractory to zoledronic acid2013

    • Author(s)
      M.Tsuda,H.Ishiguro,T Sugie,A Yasoda,M toi
    • Organizer
      11th Annual Meeting of the Japanese Society of Medical Oncology
    • Place of Presentation
      Sendai,Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Therapeutic drug monitoring of Docetaxel for a living donor liver transplantation recipient2013

    • Author(s)
      K.Kawaguchi,H.Ishiguro,I.Yano,H.Yamashiro,M.toi
    • Organizer
      11th Annual Meeting of the Japanese Society of Medical Oncology
    • Place of Presentation
      Sendai,Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Human epidermal growth factor receptor 2-targeted compounds (2): Clinical development of novel tyrosine kinase inhibitors2013

    • Author(s)
      Ishiguro H.
    • Organizer
      11th Annual Meeting of the Japanese Society of Medical Oncology JSMO/JASTRO Joint Symposium
    • Place of Presentation
      Sendai,Japan
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Predictive factors for pathologic complete response and disease-free survival after neoadjuvant chemotherapy with trastuzumab: a multicenter retrospective observational study in patients with HER2-positive primary breast cancer (JBCRG-C03 study).2013

    • Author(s)
      Takada M, Ishiguro H, Nagai S, Ohtani S, Kawabata H, Yanagita Y, Hozumi Y, Shimizu C, Takao S, Sato N, Kosaka Y, Sagara Y, Iwata H, Ohno S, Kuroi K, Masuda N, Yamashiro H, Sugimoto M, Kondo M, Naito Y, Sasano H, Inamoto T, Morita S, Toi M.
    • Organizer
      San Antonio Breast Cancer Symposium
    • Place of Presentation
      San Antonio, TX, U.S.A.
    • Related Report
      2013 Research-status Report
  • [Presentation] Phase I trial of afatinib plus vinorelbine in Japanese patients with advanced solid tumors including breast cancer.2013

    • Author(s)
      Masuda N, Mukai H, Ishiguro H, Mitsuma A, Shibata T, Yamamura J, Toi M, Watabe A, Sarashina A, Ebisawa R, Uttenreuther-Fischer M, Ando Y.
    • Organizer
      San Antonio Breast Cancer Symposium
    • Place of Presentation
      San Antonio, TX, U.S.A.
    • Related Report
      2013 Research-status Report
  • [Presentation] BOLERO-3: Everolimus Plus Trastuzumab and Vinorelbine in Asian Patients With HER2-Positive Metastatic Breast Cancer2013

    • Author(s)
      Toi M, Masuda N, Andre F, Ishiguro H, Fasolo A, Xu B, Jerusalem G, Shen K, Wilks S, O’Regan R, Isaacs C, Zhang Y, Taran T, Yap YS
    • Organizer
      San Antonio Breast Cancer Symposium
    • Place of Presentation
      San Antonio, TX, U.S.A.
    • Related Report
      2013 Research-status Report
  • [Presentation] Early response to neoadjuvant chemotherapy in breast cancer : MR Imaging for prediction of pCR.2013

    • Author(s)
      Tsuda M, Takada M, Sugie T, Kanao S, Mikami Y, Ueno T, Takeuchi M, Suzuki E, Ishiguro H, Toi M.
    • Organizer
      13th St. Gallen International Breast Cancer Conference 2013
    • Place of Presentation
      St. Gallen, Switzerland
    • Related Report
      2012 Research-status Report
  • [Presentation] Therapeutic drug monitoring of docetaxel for a living donor liver transplantation recipient.2013

    • Author(s)
      Kawaguchi K, Ishiguro H, Yano I, Yamashiro H, Toi M.
    • Organizer
      13th St. Gallen International Breast Cancer Conference 2013
    • Place of Presentation
      St. Gallen, Switzerland
    • Related Report
      2012 Research-status Report
  • [Presentation] A Multicenter Phase 2 Study (JO22997) Evaluating the Efficacy and Safety of Trastuzumab Emtansine in Japanese Patients With Heavily Pretreated HER-2-Positive Metastatic Breast Cancer.2012

    • Author(s)
      Masuda N, Ito Y, Takao S, Doihara H, Rai Y, Horiguchi J, Kohno N, Fujiwara Y, Tokuda Y, Watanabe J, Iwata H, Ishiguro H, Miyoshi Y, Matsubara M, Kashiwaba M.
    • Organizer
      San Antonio Breast Cancer Symposium
    • Place of Presentation
      San Antonio, TX, U.S.A.
    • Related Report
      2012 Research-status Report
  • [Book] Textbook of Palliative Medicine and Supportive Care, Second Edition2015

    • Author(s)
      Ishiguro H , Gomi H
    • Total Pages
      5
    • Publisher
      CRC Press
    • Related Report
      2015 Annual Research Report
  • [Book] What's New in oncology 改訂3版2015

    • Author(s)
      津田 萌、石黒 洋
    • Total Pages
      6
    • Publisher
      南山堂
    • Related Report
      2015 Annual Research Report
  • [Book] EBM がん化学療法・分子標的療法2015

    • Author(s)
      清水華子、石黒 洋
    • Total Pages
      5
    • Publisher
      中外医学社
    • Related Report
      2015 Annual Research Report
  • [Book] がん先進医療NAVIGATOR がん治療研究の最前線2015

    • Author(s)
      石黒 洋、戸井雅和
    • Total Pages
      3
    • Publisher
      日本医学出版社
    • Related Report
      2015 Annual Research Report
  • [Book] 入門腫瘍内科学改訂第2版2015

    • Author(s)
      石黒 洋
    • Total Pages
      5
    • Publisher
      篠原出版社
    • Related Report
      2015 Annual Research Report
  • [Book] Textbook of Palliative Medicine and Supportive Care,Scond Edition2015

    • Author(s)
      Ishiguro H, Gomi H
    • Total Pages
      1356
    • Publisher
      CRC Press
    • Related Report
      2014 Research-status Report
  • [Book] 入門腫瘍内科学改訂第2版2015

    • Author(s)
      石黒 洋
    • Total Pages
      234
    • Publisher
      篠原出版社
    • Related Report
      2014 Research-status Report
  • [Book] オンコロジークリニカルガイド 乳癌薬物療法2013

    • Author(s)
      河口浩介、津田萌、石黒洋
    • Total Pages
      450
    • Publisher
      南山堂
    • Related Report
      2013 Research-status Report
  • [Book] 症例から学ぶ乳癌 最新治療ストラテジー2013

    • Author(s)
      岡村見、石黒洋、戸井雅和
    • Total Pages
      173
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Research-status Report
  • [Book] JCCNB 乳がん白書20132013

    • Author(s)
      Michael Knauer、武井寛幸、石黒洋、林直輝
    • Total Pages
      157
    • Publisher
      株式会社日経メディカル開発
    • Related Report
      2013 Research-status Report
  • [Book] 先進医療NAVIGATOR II2013

    • Author(s)
      石黒洋、戸井雅和
    • Total Pages
      188
    • Publisher
      日本医学出版
    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi