| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Outline of Final Research Achievements |
We previously reported that chronic treatment of rats with ACTH may be an effective model of tricyclic antidepressant treatment-resistant conditions. Electroconvulsive stimuli and 8-OH-DPAT increased cell proliferation in both saline-treated and ACTH-treated rats. Electroconvulsive stimuli and 5-HT1A receptor full agonist, 8-OH-DPAT significantly decreased the duration of immobility following repeated administration of ACTH. Electroconvulsive stimuli treatment increased mature-brain-derived neurotrophic factor (BDNF) protein levels in the hippocampus of both saline-treated and ACTH-treated rats. Furthermore, electroconvulsive stimuli increased phospho-Ser133-CREB (pCREB) levels and the ratio of pCREB/CREB in both saline-treated and ACTH-treated rats. These findings suggest that the treatment-resistant antidepressant effects of electroconvulsive stimuli and 5-HT1A receptor full agonist may be attributed, at least in part, to an enhancement of hippocampal cell proliferation.
|
