• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The elucidation of depression and treatment-resistant depression for interaction of neuron and astrocyte function

Research Project

Project/Area Number 24590657
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied pharmacology
Research InstitutionOkayama University

Principal Investigator

KITAMURA YOSHIHISA  岡山大学, 大学病院, 准教授 (40423339)

Co-Investigator(Kenkyū-buntansha) ASANUMA Masato  岡山大学, 大学院医歯薬学総合研究科, 教授 (00273970)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords治療抵抗性うつ病 / 神経新生 / 電気けいれん療法 / セロトニン1A受容体 / 脳由来神経栄養因子 / 8-OH-DPAT / 電気けいれん / CREB / 海馬歯状回 / アストロサイト
Outline of Final Research Achievements

We previously reported that chronic treatment of rats with ACTH may be an effective model of tricyclic antidepressant treatment-resistant conditions. Electroconvulsive stimuli and 8-OH-DPAT increased cell proliferation in both saline-treated and ACTH-treated rats. Electroconvulsive stimuli and 5-HT1A receptor full agonist, 8-OH-DPAT significantly decreased the duration of immobility following repeated administration of ACTH. Electroconvulsive stimuli treatment increased mature-brain-derived neurotrophic factor (BDNF) protein levels in the hippocampus of both saline-treated and ACTH-treated rats. Furthermore, electroconvulsive stimuli increased phospho-Ser133-CREB (pCREB) levels and the ratio of pCREB/CREB in both saline-treated and ACTH-treated rats. These findings suggest that the treatment-resistant antidepressant effects of electroconvulsive stimuli and 5-HT1A receptor full agonist may be attributed, at least in part, to an enhancement of hippocampal cell proliferation.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Effects of imipramine and lithium on the expression of hippocampal Wnt 3a and cyclin D1 in ACTH-treated rats2014

    • Author(s)
      Kitamura Y, Hayashi H, Onoue Y, Kuwatsuka K, Miyake A, Miyazaki I, Asanuma M, Sendo T.
    • Journal Title

      Journal of Behavioral and Brain Sciences

      Volume: 4 Issue: 11 Pages: 483-490

    • DOI

      10.4236/jbbs.2014.411048

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of (+)-8-OH-DPAT on the duration of immobility during the forced swim test and hippocampal cell proliferation in ACTH-treated rats2014

    • Author(s)
      Miyake A., Kitamura Y., Miyazaki I., Asanuma M., Sendo T.
    • Journal Title

      Pharmacol. Biochem. Behav.

      Volume: 122 Pages: 240-245

    • DOI

      10.1016/j.pbb.2014.04.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of Bupropion and Pramipexole on Cell Proliferation in the Hippocampus of Adrenocorticotropic Hormone-Treated Rats2014

    • Author(s)
      Onoue, Y., Kuwatsuka, K., Miyazaki, I., Asanuma, M., Kitamura, Y. and Sendo, T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 37 Issue: 2 Pages: 327-330

    • DOI

      10.1248/bpb.b13-00749

    • NAID

      130003390932

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Mechanisms of Electroconvulsive Stimuli in BrdU-Positive Cells of the Dentate Gyrus in ACTH-Treated Rats2013

    • Author(s)
      Kuwatsuka, K., Hayashi, H., Onoue, Y., Miyazaki, I., Koyama, T., Asanuma, M., Kitamura, Y. and Sendo, T.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 122 Issue: 1 Pages: 34-41

    • DOI

      10.1254/jphs.13015FP

    • NAID

      10031177878

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ACTH反復投与ラットにおける5-HT1A受容体アゴニストの抗うつ効果および海馬神経新生に与える影響2013

    • Author(s)
      三宅彩香、北村佳久、服部紗代、小山敏広、宮崎育子、浅沼幹人、千堂年昭
    • Organizer
      第86回日本薬理学会 年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] ACTH反復投与ラットにおける5-HT1A受容体アゴニストの海馬神経新生および細胞内シグナリング伝達系に関する検討2012

    • Author(s)
      三宅彩香、小山敏広、宮崎育子、浅沼幹人、北村佳久
    • Organizer
      第6回次世代を担う若手医療科学シンポジウム
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Involvement of the 5-HT1A receptor function in the 8-OH-DPAT treatment on neurogenesis in ACTH-treated rats

    • Author(s)
      Kitamura Y., Miyake A, Hattori S., Koyama T., Miyazaki I., Asanuma M., Sendo T.
    • Organizer
      Neuroscience2013
    • Place of Presentation
      Washington DC(USA)
    • Related Report
      2013 Research-status Report
  • [Remarks] 岡山大学大学院医歯薬学総合研究科 臨床薬剤学分野・薬学部 臨床薬剤学分野

    • URL

      http://pharm.hospital.okayama-u.ac.jp/rinzai/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi