The elucidation of depression and treatment-resistant depression for interaction of neuron and astrocyte function
Project/Area Number |
24590657
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied pharmacology
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Research Institution | Okayama University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
ASANUMA Masato 岡山大学, 大学院医歯薬学総合研究科, 教授 (00273970)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 治療抵抗性うつ病 / 神経新生 / 電気けいれん療法 / セロトニン1A受容体 / 脳由来神経栄養因子 / 8-OH-DPAT / 電気けいれん / CREB / 海馬歯状回 / アストロサイト |
Outline of Final Research Achievements |
We previously reported that chronic treatment of rats with ACTH may be an effective model of tricyclic antidepressant treatment-resistant conditions. Electroconvulsive stimuli and 8-OH-DPAT increased cell proliferation in both saline-treated and ACTH-treated rats. Electroconvulsive stimuli and 5-HT1A receptor full agonist, 8-OH-DPAT significantly decreased the duration of immobility following repeated administration of ACTH. Electroconvulsive stimuli treatment increased mature-brain-derived neurotrophic factor (BDNF) protein levels in the hippocampus of both saline-treated and ACTH-treated rats. Furthermore, electroconvulsive stimuli increased phospho-Ser133-CREB (pCREB) levels and the ratio of pCREB/CREB in both saline-treated and ACTH-treated rats. These findings suggest that the treatment-resistant antidepressant effects of electroconvulsive stimuli and 5-HT1A receptor full agonist may be attributed, at least in part, to an enhancement of hippocampal cell proliferation.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Effects of Bupropion and Pramipexole on Cell Proliferation in the Hippocampus of Adrenocorticotropic Hormone-Treated Rats2014
Author(s)
Onoue, Y., Kuwatsuka, K., Miyazaki, I., Asanuma, M., Kitamura, Y. and Sendo, T.
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 37
Issue: 2
Pages: 327-330
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Mechanisms of Electroconvulsive Stimuli in BrdU-Positive Cells of the Dentate Gyrus in ACTH-Treated Rats2013
Author(s)
Kuwatsuka, K., Hayashi, H., Onoue, Y., Miyazaki, I., Koyama, T., Asanuma, M., Kitamura, Y. and Sendo, T.
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Journal Title
Journal of Pharmacological Sciences
Volume: 122
Issue: 1
Pages: 34-41
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed
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