The construction of a means to overcome cancerous multidrug resistance by mediating the post-translational regulators of drug-efflux transporters
Project/Area Number |
24590667
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied pharmacology
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Research Institution | Takasaki University of Health and Welfare |
Principal Investigator |
OGIHARA Takuo 高崎健康福祉大学, 薬学部, 教授 (80448886)
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Co-Investigator(Kenkyū-buntansha) |
KAORI Morimoto 高崎健康福祉大学, 薬学部, 講師 (90401009)
MASAHIRO Kajita 高崎健康福祉大学, 薬学部, 准教授 (40591871)
YOKO Idota 高崎健康福祉大学, 薬学部, 研究員 (90629594)
KENTARO Yano 高崎健康福祉大学, 薬学部, 助手 (40644290)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | P-糖タンパク / がん多剤耐性 / 裏打ちタンパク / 膜上発現 / 調節因子 / ERMタンパク / 組織選択性 / radixin / 多剤耐性 / 排出組織 / がん細胞 / 正常組織 / 輸送活性 / ラディキシン / 消化管吸収 / トランスポーター / 脳組織移行性 / シルニジピン / 脳保護作用 |
Outline of Final Research Achievements |
P-glycoprotein (P-gp) excretes many therapeutic drugs from the cytoplasm to outside the cells. Therefore, it is well known as a major factor in multidrug resistance of cancer cells. Our previous study demonstrated that radixin among ezrin, radixin and moesin (ERM proteins) regulated P-gp transport activity and membrane localization. In this study, we investigated the relationship between P-gp and ERM proteins in cancer cells from other organs. The transport activity of intestinal P-gp was regulated by radixin in both normal and cancer cells. On the other hand, it was suggested that none of the ERM proteins affected the renal P-gp in either normal or cancer cells. Thus, we hypothesize that the functional regulation mechanism of P-gp via ERM proteins varies between different organs, such as the intestine and kidney, but not between normal and cancer cells in the same organ.
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Report
(4 results)
Research Products
(31 results)
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[Presentation] P-glycoprotein Plays a Key Role in the Contractionary Effects against Brain Infarction of2014
Author(s)
Takumi Tomono, Kentaro Yano, Toshimitsu Motegi, Shinobu Takimoto, Mihoko Hagiwara, Yoko Idota, Takashi Kano, Hiroshi Arakawa, Kaori Morimoto, Chihaya Kakinuma, Akira Takahara, Takuo Ogihara
Organizer
19th North American ISSX/29th JSSX Meeting
Place of Presentation
サンフランシスコ
Year and Date
2014-10-19 – 2014-10-23
Related Report
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