Development of platinum nanoparticles as reactive oxygen species scavengers for the treatment of hepatic metastasis
| Project/Area Number |
24590670
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Akira 京都薬科大学, 薬学部, 教授 (00166779)
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| Research Collaborator |
KUSAMORI Kosuke
SAKAI Kosuke
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 薬学 / 薬剤学 / 薬物送達システム / ナノ粒子 / 白金 / 活性酸素 / 肝転移 / 肝疾患 |
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| Outline of Final Research Achievements |
Reactive oxygen species (ROS) are involved in the hepatic metastasis. To prevent hepatic metastasis, we prepared citric acid-protected platinum nanoparticles (Pt-NPs), which exhibited ROS-scavenging activities and selective delivery to a specific type of liver cell. Pt-NPs reduced the superoxide anion, hydrogen peroxide, and hydroxyl radical levels in solution. Pt-NPs predominantly accumulated in hepatic nonparenchymal cells after intravenous injections in mice. In a mouse model of hepatic metastasis, the number of tumor cells in the liver was effectively reduced by a bolus intravenous injection of Pt-NPs. These results indicate that Pt-NPs are promising compounds for preventing hepatic metastasis.
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Report
(4 results)
Research Products
(13 results)
