A functional search for pharmacogenomic biomarker of the drugs on inflammatory bowel disease, and suggestion of its utilization

Research Project

Project/Area Number	24590671
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Applied pharmacology
Research Institution	Hyogo University of Health Sciences
Principal Investigator	OHNO Masako 兵庫医療大学, 薬学部, 講師 (50467528)
Co-Investigator(Renkei-kenkyūsha)	AZUMA Junichi 兵庫医療大学, 薬学部, 教授 (30144463)
Project Period (FY)	2012-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	ファーマコゲノミクス / アザチオプリン / 炎症性腸疾患
Outline of Final Research Achievements	Azathioprine (AZA) is an important immunomodulator used for inflammatory bowel disease. Its use is unfortunately limited due to marked inter-individual differences in responses to the drug. In this study, we found the pharmacogenomic factors that may be involved in safety or efficacy during AZA therapy. The findings suggest that the SNPs contribute to the optimization of low-dose AZA treatment. Educational program was also designed through the study to nurture the clinical research mind of the pharmacy student.

Report

(5 results)