Development of a novel assay for prediction of response to anti-EGFR antibody therapy in colorectal cancer
Project/Area Number |
24590674
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
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Research Institution | Hokkaido University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 分子標的治療 / 治療抵抗性 / コンパニオン診断 / 大腸癌 / 治療効果予測 |
Outline of Final Research Achievements |
In this study, we attempted to develop a novel method to predict response to anti-EGFR therapy in colorectal cancer. A sensitive EGFR detection method using cetuximab and the simplified surrogate method were successfully established. However, these methods failed to enrich any responders to the therapy in RAS/BRAF wild-type colorectal cancer. We therefore explored novel predictive markers for the therapy by a comprehensive analysis of two different cell lines, KRAS wild-type and mutant, and identified twelve genes that changed between these cells. It is suggested that these candidate genes including a membrane protein related to nucleic acid metabolism might be predictive markers of anti-EGFR therapy.
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Report
(5 results)
Research Products
(33 results)
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[Journal Article] ZEB1 expression is associated with prognosis of intrahepatic cholangiocarcinoma2016
Author(s)
Terashita K, Chuma M, Hatanaka Y, Hatanaka K, Mitsuhashi T, Yokoo H, Ohmura T, Ishizu H, Muraoka S, Nagasaka A, Tsuji T, Yamamoto Y, Kurauchi N, Shimoyama N, Toyoda H, Kumada T, Kaneoka Y, Maeda A, Ogawa K, Natsuizaka M, Kamachi H, Kakisaka T, Kamiyama T, Taketomi A, Matsuno Y, Sakamoto N
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Journal Title
J Clin Pathol
Volume: in press
Issue: 7
Pages: 593-599
DOI
Related Report
Peer Reviewed
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[Journal Article] Comparative genetic analysis of a rare synchronous collision tumor composed of malignant pleural mesothelioma and primary pulmonary adenocarcinoma.2016
Author(s)
Naka T, Hatanaka Y, Marukawa K, Okada H, Hatanaka KC, Sakakibara-Konishi J, Oizumi S, Hida Y, Kaga K, Mitsuhashi T, Matsuno Y
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Journal Title
Diagn Pathol
Volume: 11
Issue: 1
Pages: 1-6
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] EGFR inhibitors prevent induction of cancer stem-like cells in esophageal squamous cell carcinoma by suppressing epithelial-mesenchymal transition.2015
Author(s)
Sato F, Kubota Y, Natsuizaka M, Maehara O, Hatanaka Y, Marukawa K, Terashita K, Suda G, Ohnishi S, Shimizu Y, Komatsu Y, Ohashi S, Kagawa S, Kinugasa H, Whelan KA, Rustgi AK, Nakagawa H, Sakamoto N.
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Journal Title
Cancer Biol Ther
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Immunohistochemical Validation and Expression Profiling of NKG2D Ligands in a Wide Spectrum of Human Epithelial Neoplasms.2015
Author(s)
Fujita H, Hatanaka Y, Sutoh Y, Suzuki Y, Oba K, Hatanaka KC, Mitsuhashi T, Otsuka N, Fugo K, Kasahara M, Matsuno Y.
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Journal Title
J Histochem Cytochem.
Volume: 63
Issue: 3
Pages: 217-227
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] CTNNB1 mutational analysis of solid-pseudopapillary neoplasms of the pancreas using endoscopic ultrasound-guided fine-needle aspiration and next-generation deep sequencing.2014
Author(s)
Kubota Y, Kawakami H, Natsuizaka M, Kawakubo K, Marukawa K, Kudo T, Abe Y, Kubo K, Kuwatani M, Hatanaka Y, Mitsuhashi T, Matsuno Y, Sakamoto N.
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Journal Title
J Gastroenterol.
Volume: in press
Issue: 2
Pages: 203-210
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Differential expression of progesterone receptor, FOXA1, GATA3, and p53 between pre- and postmenopausal women with estrogen receptor-positive breast cancer.2014
Author(s)
Hosoda M, Yamamoto M, Nakano K, Hatanaka KC, Takakuwa E, Hatanaka Y, Matsuno Y, Yamashita H
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Journal Title
Breast Cancer Res Treat.
Volume: 144
Issue: 2
Pages: 249-61
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Validity and reproducibility of Ki-67 assessment in gastrointestinal stromal tumors and leiomyosarcomas.2013
Author(s)
Ogino J, Asanuma H, Hatanaka Y, Matsuno Y, Gotoda H, Muraoka S, Tsuji T, Fukazawa Y, Yamashiro K, Kondo N, Iwaki H, Miyokawa N, Hasegawa T.
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Journal Title
Pathol Int
Volume: 63巻
Issue: 2
Pages: 102-107
DOI
Related Report
Peer Reviewed
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