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Microbiological and molecular epidemiological analyses of community-associated methicillin-resistant Staphylococcus aureus in Japan

Research Project

Project/Area Number 24590676
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionNara Medical University (2014)
Tohoku University (2012-2013)

Principal Investigator

YANO Hisakazu  奈良県立医科大学, 医学部, 教授 (20374944)

Co-Investigator(Kenkyū-buntansha) KUNISHIMA Hiroyuki  聖マリアンナ医科大学, 医学部, 准教授 (60339843)
Research Collaborator INOMATA Shinya  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsMRSA / CA-MRSA / 市中感染型MRSA
Outline of Final Research Achievements

In this study, the MRSA isolates were classified as CA-MRSA or hospital-associated (HA)-MRSA according to a clinical classification based on patient information and a molecular classification based on SCCmec typing. Additionally, we performed PFGE and MLST.
Of the 231 MRSA isolates, 28 and 78 were classified as CA-MRSA by the clinical and molecular classifications, respectively. The most frequently detected CA-MRSA clone was sequence type 5-SCCmec IV, which has not previously been reported in Japan. The numbers of detected CA-MRSA isolates differed between the molecular classification and the clinical classification and the CA-MRSA detection frequency and the presence of the ST5-SCCmec IV clone were distinctive features in Japan.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (25 results)

All 2015 2014 2013 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 1 results) Presentation (15 results) (of which Invited: 8 results) Book (1 results)

  • [Journal Article] A case of culture-negative endocarditis due to Streptococcus tigurinus2015

    • Author(s)
      Kanamori H, Kakuta R, Yano H, Suzuki T, Gu Y, Oe C, Inomata S, Aoyagi T, Hatta M, Endo S, Tokuda K, Weber DJ, Nakamura Y, Saiki Y, Kaku M
    • Journal Title

      J Infect Chemother

      Volume: 21 Issue: 2 Pages: 138-140

    • DOI

      10.1016/j.jiac.2014.08.014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of Smqnr and plasmid-mediated quinolone resistance determinants in clinical isolates of Stenotrophomonas maltophilia from Japan: novel variants of Smqnr2015

    • Author(s)
      Kanamori H, Yano H, Tanouchi A, Kakuta R, Endo S, Ichimura S, Ogawa M, Shimojima M, Inomata S, Ozawa D, Aoyagi T, Weber DJ, Kaku M
    • Journal Title

      New Microbes New Infect

      Volume: 3 Pages: 1-1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of the 7-valent pneumococcal conjugate vaccine on acute otitis media in Japanese children: Emergence of serotype 15A multi-drug resistant Streptococcus pneumoniae in middle ear fluid isolates2015

    • Author(s)
      Ozawa D, Yano H, Endo S, Hidaka H, Kakuta R, Okitsu N, Kanamori H, Ogawa M, Ichimura S, Shimojima M, Inomata S, Kaku M, and Katori Y
    • Journal Title

      Pediatr Infect Dis J

      Volume: 34 Pages: 1-1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of prior pandemic A(H1N1) 2009 virus infection on invasion of MDCK cells by community-associated methicillin-resistant Staphylococcus aureus2014

    • Author(s)
      Takayama Y, Yano H, Nojima Y, Nakano R, Okamoto R, Hirakata Y, Sunakawa K, Akahoshi T, and Kaku M
    • Journal Title

      J Infect Chemother

      Volume: 20 Issue: 1 Pages: 71-73

    • DOI

      10.1016/j.jiac.2013.07.012

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of Chlamydia trachomatis or Neisseria gonorrhoeae in otorhinolaryngology patients with pharyngeal symptoms2014

    • Author(s)
      Oda K, Yano H, Okitsu N, Chiba T, Hara Y, Kudo T, Ozawa D, Irimada M, and Ohyama K
    • Journal Title

      Sexually Transmitted Infections

      Volume: 90 Issue: 2 Pages: 99-99

    • DOI

      10.1136/sextrans-2013-051419

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High Frequency of Acinetobacter soli Among Acinetobacter Isolates Causing Bacteremia at a Japanese Tertiary Hospital2014

    • Author(s)
      Shiro Endo, Hisakazu Yano, Hajime Kanamori, Shinya Inomata, Tetsuji Aoyagi, Masumitsu Hatta, Yoshiaki Gu, Koichi Tokuda, Miho Kitagawa, Mitsuo Kaku
    • Journal Title

      Journal of Clinical Microbiology

      Volume: 52 Issue: 3 Pages: 911-915

    • DOI

      10.1128/jcm.03009-13

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of severe acute otitis media caused by mucoid Streptococcus pyogenes in a previously healthy adult2014

    • Author(s)
      Kakuta R, Yano H, Hidaka H, Miyazaki H, Irimada M, Oda K, Arai K, Ozawa D, Takahashi T, Kaku M, and Katori Y
    • Journal Title

      Tohoku J Exp Med

      Volume: 232 Pages: 301-304

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Helicobacter cinaedi causing infected abdominal aortic aneurysm2014

    • Author(s)
      Kakuta R, Yano H, Kanamori H, Shimizu T, Gu Y, Hatta M, Aoyagi T, Endo S, Inomata S, Oe C, Tokuda K, Ozawa D, Goto H, Katori Y, and Kaku M
    • Journal Title

      Emerg Infect Dis

      Volume: 20 Issue: 11 Pages: 1942-1945

    • DOI

      10.3201/eid2011.140440

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Twelve-year survey (2001-2012) of the antimicrobial susceptibility of Streptococcus pneumoniae isolates from otorhinolaryngology clinics in Miyagi Prefecture, Japan2014

    • Author(s)
      Ozawa D, Yano H, Hidaka H, Kakuta R, Komatsu M, Endo S, Kanamori H, Kaku M, and Katori Y
    • Journal Title

      J Infect Chemother

      Volume: 20 Issue: 11 Pages: 702-708

    • DOI

      10.1016/j.jiac.2014.07.014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 小児気道感染症におけるインフルエンザ菌のトピックス2015

    • Author(s)
      矢野寿一
    • Organizer
      第26回日本臨床微生物学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-01-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 感染症の新しい検査法、新しい検査とこれまでの検査の共存2014

    • Author(s)
      矢野寿一
    • Organizer
      第88回日本感染症学会学術講演会
    • Place of Presentation
      福岡
    • Year and Date
      2014-06-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 小児耳鼻咽喉科領域におけるインフルエンザ菌のトピックス2014

    • Author(s)
      矢野寿一
    • Organizer
      第9回小児耳鼻咽喉科学会
    • Place of Presentation
      浜松
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Molecular epidemiology and characteristics of extended-spectrum β-lactamase-producing Escherichia coli in the Japanese clinical setting2014

    • Author(s)
      Yano H, Tanouchi A, Endo S, Kanamori H, Aoyagi T, Hatta M, Gu Y, Tokuda K, Kitagawa M, and Kaku M
    • Organizer
      24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
    • Place of Presentation
      Barcelona
    • Year and Date
      2014-05-10 – 2014-05-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] First confirmed case of spondylodiscitis and epidural abscess due to Parvimonas micra: review of Parvimonas micra infection2014

    • Author(s)
      Endo S, Nemoto T, Yano H, Kanamori H, Aoyagi T, Hatta M, Gu Y, Tokuda K, Kitagawa M, and Kaku M
    • Organizer
      24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
    • Place of Presentation
      Barcelona
    • Year and Date
      2014-05-10 – 2014-05-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] One-year epidemiological and molecular analysis of community- and hospital-associated methicillin-resistant Staphylococcus aureus in a tertiary hospital in Japan using phage open-reading frame typing2014

    • Author(s)
      Inomata S, Tokuda K, Yano H, Ishizawa C, Endo S, Kanamori H, Aoyagi T, Hatta M, Gu Y, and Kaku M
    • Organizer
      24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
    • Place of Presentation
      Barcelona
    • Year and Date
      2014-05-10 – 2014-05-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Characterisation of ampicillin-resistant Haemophilus influenzae isolates in middle ear fluid from Japanese children with acute otitis media2014

    • Author(s)
      Kakuta R, Yano H, Hidaka H, Ogawa M, Tanouchi A, Ozawa D, Endo S, Kanamori H, Kaku M, and Katori Y
    • Organizer
      24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
    • Place of Presentation
      Barcelona
    • Year and Date
      2014-05-10 – 2014-05-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Molecular epidemiology of Acinetobacter spp. causing bacteraemia in Japanese community hospitals2014

    • Author(s)
      Endo S, Yano H, Kanamori H, Inomata S, Aoyagi T, Hatta M, Gu Y, Tokuda K, Kitagawa M, and Kaku M
    • Organizer
      24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
    • Place of Presentation
      Barcelona
    • Year and Date
      2014-05-10 – 2014-05-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] One-year epidemiological and molecular analysis of community- and hospital-associated methicillin-resistant Staphylococcus aureus in tertiary hospital in Japan using Phage-Open reading frame Typing2014

    • Author(s)
      Shinya Inomata, Koichi Tokuda, Hisakazu Yano, Chiyuki Ishizawa, Shiro Endo, Hajime Kanamori, Tetsuji Aoyagi, Masumitsu Hatta, Yoshiaki Gu, Mitsuo Kaku
    • Organizer
      ECCMID
    • Place of Presentation
      バルセロナ、スペイン
    • Related Report
      2013 Research-status Report
  • [Presentation] 小児科・耳鼻科領域でみられる耐性菌の現状と問題点2013

    • Author(s)
      矢野寿一
    • Organizer
      第1回中部地区耳鼻・小児疾患研究会
    • Place of Presentation
      沖縄
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 耳鼻科領域感染症でみられる薬剤耐性菌の現状と問題点2013

    • Author(s)
      矢野寿一
    • Organizer
      第24回岡山耳鼻咽喉科感染免疫研究会
    • Place of Presentation
      岡山
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 多剤耐性菌に関する最近のトピックス2013

    • Author(s)
      矢野寿一
    • Organizer
      感染症セミナー in 川越
    • Place of Presentation
      川越
    • Related Report
      2012 Research-status Report
  • [Presentation] MRSAの基礎と最近の話題

    • Author(s)
      矢野寿一
    • Organizer
      第12回宮城外科フォーラム
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 薬剤耐性菌の基礎と最近の話題~ESBL, MDRP, MRSAを中心に~

    • Author(s)
      矢野寿一
    • Organizer
      第15回仙塩地区院内感染症研究会
    • Place of Presentation
      多賀城
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 耳鼻咽喉科領域感染症でみられる耐性菌の現状と問題点

    • Author(s)
      矢野寿一
    • Organizer
      第42回和歌山感染症化学療法研究会
    • Place of Presentation
      和歌山
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 感染症診療update2015

    • Author(s)
      小澤大樹、矢野寿一
    • Total Pages
      2
    • Publisher
      日本医師会
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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