Clinicopathological features of malignant lymphoma in Miyagi study

• Project/Area Number: 24590677
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Tohoku University
• Principal Investigator: ICHINOHASAMA Ryo 東北大学, 大学病院, 教授 (30184625)
• Co-Investigator(Kenkyū-buntansha): FUKUHARA Noriko 東北大学, 大学病院, 講師 (10534167) ; ISHIZAWA Kenichi 山形大学, 大学院医学系研究科, 教授 (00359506)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 悪性リンパ腫 / 疫学

Outline of Final Research Achievements

A total of 3,043 cases of newly diagnosed malignant lymphoma in Miyagi between 2002 and 2012 were enrolled in this epidemiological study. The rate of each subtype was mostly similar to that in our previous report. The most frequent subtype of B-cell lymphoma was diffuse large B-cell lymphoma (DLBCL), followed by follicular lymphoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (38.6%, 19.7% and 7.5%).
To identify the biological prognostic factors in DLBCL, we analyzed biological parameters (BCL2, BCL6, c-MYC and BACH2). In cases with high BACH2 expression in GCB (38 cases) and non-GCB groups (38 cases), the 3-year overall survival (OS) rate was significantly shorter than that with low expression (71.7% vs 91.3%, P = 0.0256). In the DLBCL with MYC translocation (n=18), expression of BACH2 may be a prognostic marker (3y OS 75.0% vs 22.9%, P=0.132). BACH2, a B cell-specific transcriptional repressor, may plays a significant role in B cell lymphoma.

Research Products

• [Journal Article] びまん性大細胞型B細胞リンパ腫におけるBACH2発現の臨床病理学的意義 (2015)
  • Author(s): 市川 聡、福原 規子、一迫 玲、張替 秀郎
  • Journal Title: 血液内科 Volume: 70 Pages: 82-86
  • NAID: 40020341682
• [Journal Article] Analysis of clinical characteristics and prognostic factors for angioimmunoblastic T-cell lymphoma. (2015)
  • Author(s): Kameoka Y, Ishizawa Y, Ichinohasama R.
  • Journal Title: Int J Hematol. Volume: 未定
  • Peer Reviewed
• [Journal Article] Heparin-responsive angiopathy in the central nervous system caused by intravasular large B-cell lymphoma. (2015)
  • Author(s): Yoshida S, Fukuhara N, Aoki M.
  • Journal Title: J Neurol Sci. Volume: 352 Issue: 1-2 Pages: 117-119
  • DOI: 10.1016/j.jns.2015.03.026
  • Peer Reviewed
• [Journal Article] 本邦初のリンパ腫総合診断システム：READsystem 25年小史 データ保存方法の推移と考察を含む（解説） (2014)
  • Author(s): 一迫 玲
  • Journal Title: 病理と臨床 Volume: 32 Pages: 1055-1059
• [Journal Article] Association between BACH2 expression and clinical prognosis in diffuse large B-cell lymphoma. (2014)
  • Author(s): Ichikawa, S., Fukuhara, N., Katsushima, H., Takahashi, T., Yamamoto, J., Yokoyama, H., Sasaki, O., Fukuhara, O., Nomura, J., Ishizawa, K., Ichinohasama, R., Muto, A., Igarashi, K., and Harigae, H.
  • Journal Title: Cancer Science Volume: in press Issue: 4 Pages: 437-444
  • DOI: 10.1111/cas.12361
  • Peer Reviewed / Open Access
• [Journal Article] Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis. (2014)
  • Author(s): Suguro M, Yoshida N, Umino A, Kato H, Tagawa H, Nakagawa M, Fukuhara N, Karnan S, Takeuchi I, Hocking TD, Arita K, Karube K, Tsuzuki S, Nakamura S, Kinoshita T, Seto M.
  • Journal Title: Cancer Sci. Volume: 105 Issue: 7 Pages: 897-904
  • DOI: 10.1111/cas.12442
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A multicentre phase II study of vorinostat in patients with relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma. (2014)
  • Author(s): Ogura M, Ando K, Suzuki T, Ishizawa K, Oh SY, Itoh K, Yamamoto K, Au WY, Tien HF, Matsuno Y, Terauchi T, Yamamoto K, Mori M, Tanaka Y, Shimamoto T, Tobinai K, Kim WS.
  • Journal Title: Br J Haematol Volume: 165 Issue: 6 Pages: 768-776
  • DOI: 10.1111/bjh.12819
  • Peer Reviewed
• [Journal Article] Phase Ⅰ/Ⅱ study of brentuximab vedotin in Japanese patients with relapsed or refractory CD30-positive Hodgkin's lymphoma or systemic anaplastic large-cell lymphoma. (2014)
  • Author(s): Ogura M, Ishizawa K.
  • Journal Title: Cancer Sci. Volume: 105 Issue: 7 Pages: 840-846
  • DOI: 10.1111/cas.12435
  • Peer Reviewed
• [Journal Article] Multicenter phase II study of mogamulizumab (KW-0761), a defucosylated anti-cc chemokine receptor 4 antibody, in patients with relapsed peripheral T-cell lymphoma and cutaneous T-cell lymphoma. (2014)
  • Author(s): Ogura M, Ishida T, Hatake K, Taniwaki M, Ando K, Tobinai K, Fujimoto K, Yamamoto K, Miyamoto T, Uike N, Tanimoto M, Tsukasaki K, Ishizawa K, Suzumiya J, Inagaki H, Tamura K, Akinaga S, Tomonaga M, Ueda R.
  • Journal Title: J Clin Oncol Volume: 32 Issue: 11 Pages: 1157-1163
  • DOI: 10.1200/jco.2013.52.0924
  • Peer Reviewed
• [Journal Article] Prognostic biomarkers in patients with localized natural killer/T-cell lymphoma treated with concurrent chemoradiotherapy. (2014)
  • Author(s): Yamaguchi M, Takata K, Yoshino T, Ishizuka N, Oguchi M, Kobayashi Y, Isobe Y, Ishizawa K, Kubota N, Itoh K, Usui N, Miyazaki K, Wasada I, Nakamura S, Matsuno Y, Oshimi K, Kinoshita T, Tsukasaki K, Tobinai K.
  • Journal Title: Cancer Sci Volume: 105 Issue: 11 Pages: 1435-1441
  • DOI: 10.1111/cas.12526
  • Peer Reviewed
• [Journal Article] Fatal visceral varicella-zoster developing early after autologous hematopoietic stem cell transplantation for refractory diffuse large B-cell lymphoma. (2014)
  • Author(s): Ichikawa S, Fukuhara N, Ishizawa K.
  • Journal Title: J Clin Exp Hematop. Volume: 54 Pages: 237-241
  • NAID: 130004705271
  • Peer Reviewed
• [Journal Article] がん薬物療法の支持療法・副作用対策・リスク／コストベネフィット 腫瘍崩壊症候群 (2014)
  • Author(s): 石澤賢一
  • Journal Title: 腫瘍内科 Volume: 2 Pages: 159-167
• [Journal Article] 総説・腫瘍崩壊症候群と診療ガイドライン (2014)
  • Author(s): 石澤賢一
  • Journal Title: Japanese Jornal of Cancer and Chemotherapy Volume: 41 Pages: 135-140
• [Journal Article] 抗CD20抗体薬と抗CD52抗体薬 (2014)
  • Author(s): 石澤賢一
  • Journal Title: 最新医学 Volume: 69 Pages: 379-385
• [Journal Article] オファツムマブ (2014)
  • Author(s): 福原規子
  • Journal Title: 最新医学 Volume: 102 Pages: 108-114
• [Journal Article] Clinicopathological analysis of primary adrenal diffuse large b-cell lymphoma : Effectiveness of rituximab-containing chemotherapy including central nervous system prophylaxis (2013)
  • Author(s): Ichikawa S, Fukuhara N, Inoue A, Katsushima H, Ohba R, Katsuoka Y, Onishi Y, Yamamoto J, Sasaki O, Nomura J, Fukuhara O, Ishizawa K, Ichinohasama R, Harigae H
  • Journal Title: Exp Hematol Oncol Volume: 2 Issue: 1 Pages: 19-19
  • DOI: 10.1186/2162-3619-2-19
  • Peer Reviewed
• [Journal Article] Web介在/次世代型の病理診断システム 悪性リンパ腫疑い症例用/READsystemの場合 (2013)
  • Author(s): 一迫玲
  • Journal Title: 臨床と病理 Volume: 31 Pages: 805-807
• [Journal Article] 濾胞性リンパ腫の治療－いつ開始し、どう治療するか (2013)
  • Author(s): 福原規子、石澤賢一
  • Journal Title: mebio Volume: 30 Pages: 31-39
• [Journal Article] T-cell/histiocyte-rich large B-cell lymphoma of the thyroid. (2013)
  • Author(s): Ichikawa S, Ichinohasama R, et al.
  • Journal Title: Exp Hematol Oncol. Volume: 2 Issue: 1 Pages: 1-3
  • DOI: 10.1186/2162-3619-2-1
  • Peer Reviewed
• [Journal Article] CD4 and CD8 double-negative adult T-cell leukemia/lymphoma with monomorphic cells expressing CD99: A diagnostic challenge in a country non-endemic for human T-cell leukemia virus. (2013)
  • Author(s): Lin TH, Ichinohasama R, et al.
  • Journal Title: Pathol Int. Volume: 63 Issue: 2 Pages: 132-137
  • DOI: 10.1111/pin.12040
  • Peer Reviewed
• [Journal Article] Phase II study of ABV (doxorubicin with increased dose, bleomycin and vinblastine) therapy in newly diagnosed advanced-stage Hodgkin lymphoma: Japan Clinical Oncology Group study (JCOG9705). (2013)
  • Author(s): Ogura M, Ishizawa K, et al.
  • Journal Title: Leuk Lymphoma. Volume: 54 Issue: 1 Pages: 46-52
  • DOI: 10.3109/10428194.2012.705000
  • Peer Reviewed
• [Journal Article] Immunoglobulin G4-positive plasmablastic lymphoma. (2012)
  • Author(s): Yokoyama H, Ichinohasama R.
  • Journal Title: Leukemia Lymphoma Volume: 53 Issue: 10 Pages: 2075-2077
  • DOI: 10.3109/10428194.2012.668680
  • Peer Reviewed
• [Journal Article] CD20-positive and CD4/CD8-double-negative peripheral T-cell lymphoma of spleen complicated with severe disseminated intravascular coagulation and enteropathy. (2012)
  • Author(s): Ichikawa S, Ichinohasama R, et al.
  • Journal Title: J Clin Exp Hematop. Volume: 52 Pages: 133-136
  • NAID: 10031120438
  • Peer Reviewed
• [Journal Article] Philadelphia-negative acute promyelocytic leukemia in a patient with chronic myeloid leukemia in complete cytogenetic response after treatment with tyrosine kinase inhibitor. (2012)
  • Author(s): Inokura K, Onishi Y, Shimosegawa K, Okitsu Y, Katsuoka Y, Fujiwara T, Fukuhara N, Ishizawa K, Harigae H.
  • Journal Title: Annals of hematology Volume: 91 Issue: 11 Pages: 1825-1826
  • DOI: 10.1007/s00277-012-1477-3
  • Peer Reviewed
• [Journal Article] Concurrent chemoradiotherapy for localized nasal natural killer/T-cell lymphoma: an updated analysis of the Japan clinical oncology group study JCOG0211. (2012)
  • Author(s): Yamaguchi M, Ishizawa K, et al.
  • Journal Title: J Clin Oncol. Volume: 30 Issue: 32 Pages: 4044-4046
  • DOI: 10.1200/jco.2012.45.6541
  • Peer Reviewed
• [Journal Article] Safety and feasibility of high-dose ranimustine (MCNU), carboplatin, etoposide, and cyclophosphamide (MCVC) therapy followed by autologous stem cell transplantation for malignant lymphoma (2012)
  • Author(s): Kameoka Y, Takahashi N, Ishizawa K, Kato Y, Ito J, Sasaki O, Murai K, Noji H, Hirokawa M, Tajima K, Shichishima T, Ishida Y, Harigae H, Sawada K
  • Journal Title: Int J Hematol Volume: 96(5) Issue: 5 Pages: 624-630
  • DOI: 10.1007/s12185-012-1186-7
  • NAID: 10031126760
  • Peer Reviewed
• [Journal Article] どのような場合に低悪性度リンパ腫を無治療経過観察とするか (2012)
  • Author(s): 福原規子、石澤賢一
  • Journal Title: 血液内科 Volume: 64 Pages: 690-694
• [Journal Article] 未治療低腫瘍量濾胞性リンパ腫に対する標準治療と最新の臨床試験の動向 (2012)
  • Author(s): 福原規子
  • Journal Title: 血液内科 Volume: 65 Pages: 65-71
• [Journal Article] 濾胞性リンパ腫 (2012)
  • Author(s): 石澤賢一
  • Journal Title: 内科 Volume: 110 Pages: 213-217
• [Journal Article] 超高悪性度B細胞性リンパ腫に対する薬物療法 バーキットリンパ腫 (2012)
  • Author(s): 石澤賢一
  • Journal Title: 臨床腫瘍プラクティス Volume: 8 Pages: 253-257
• [Journal Article] 濾胞性リンパ腫の標準治療とresearch questions (2012)
  • Author(s): 石澤賢一
  • Journal Title: 臨床血液 Volume: 53 Pages: 1624-1633
  • NAID: 10031123851
• [Presentation] The clinical signilicance of BACH2 expression in diffuse large B-cell lymphoma (2014)
  • Author(s): Ichikawa Satoshi,Fukuhara Noriko
  • Organizer: 日本血液学会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] FR Therapy followed by 90Y-ibritumomab tiuxetan for relapsed indolent B Cell lymphoma, phase 1 study. (2014)
  • Author(s): Himuro M, Fukuhara N, Ishizawa K.
  • Organizer: 日本血液学会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Prognostic biomarkers in patients with localized NK/T-cell lymphoma treated with RT-DeVIC (2014)
  • Author(s): Tanaka K, Ishizawa K.
  • Organizer: 日本血液学会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] A nationwide survey of patients with adult T Cell leukemia/lymphoma(ATL)in Japan:2010-2011. (2014)
  • Author(s): Nosaka K, Ishizawa K.
  • Organizer: 日本血液学会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Phase I study of darinaparsin in Japanese patients with relapsed or refractory PTCL. (2014)
  • Author(s): Uchida T, Ishizawa K.
  • Organizer: 日本血液学会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] リンパ系腫瘍“Watch & Waite”は現在でも標準治療か？“濾胞性リンパ腫における“Watch & Waite”の役割” (2014)
  • Author(s): 石澤賢一
  • Organizer: 日本臨床腫瘍学会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-07-17 – 2014-07-19
  • Invited
• [Presentation] 腫瘍崩壊症候群の治療 (2014)
  • Author(s): 石澤賢一
  • Organizer: 日本臨床腫瘍学会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-07-17 – 2014-07-19
  • Invited
• [Presentation] 多発脳神経障害で発症し進行性の馬尾病変をきたした原発性神経リンパ腫症の一例 (2014)
  • Author(s): 加藤 浩貴、福原 規子、石澤賢一
  • Organizer: 日本リンパ網内系学会
  • Place of Presentation: 山形国際ホテル（山形市）
  • Year and Date: 2014-06-19 – 2014-06-21
• [Presentation] 骨髄生検でB－リンパ芽球性H白血病/リンパ腫と濾胞性リンパ腫が同時に認められた－ (2014)
  • Author(s): 勝嶌 浩紀、福原 規子、一迫 玲
  • Organizer: 日本病理学会
  • Place of Presentation: 広島国際会議場（広島市）
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] Weber-Christian病として治療中にsubcutaneous panniculitis-like T cell lymphomaが出現した一例 (2013)
  • Author(s): 勝嶌浩紀、一迫玲
  • Organizer: 日本リンパ網内系学会学術集会
  • Place of Presentation: 京都市
• [Presentation] 悪性リンパ腫治療の進歩、アグレッシブリンパ腫の治療 (2013)
  • Author(s): 石澤賢一
  • Organizer: 第51回日本癌治療学会学術集会
  • Place of Presentation: 京都市
  • Invited
• [Presentation] Latest research outcomes and future development of antibody therapyCD20とCD52を標的とするB細胞性慢性リンパ性白血病の抗体療法 (2013)
  • Author(s): 石澤賢一
  • Organizer: 第11回日本臨床腫瘍学会学術集会
  • Place of Presentation: 仙台市
  • Invited
• [Presentation] A clinicopathological analysis of lymphoproliferative disorders in rheumatoid arthritis (2013)
  • Author(s): 鴨川由紀子、福原規子、石澤賢一、一迫玲
  • Organizer: 第11回日本臨床腫瘍学会学術集会
  • Place of Presentation: 仙台市
• [Presentation] Clinicopathological analysis of primary adrenal diffuse large B-cell lymphoma (2013)
  • Author(s): 市川聡、福原規子、石澤賢一、一迫玲
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] A case of B lymphoblastic leukemia/lymphoma with complex karyotype involving t(14;18)(q32;q21) (2013)
  • Author(s): 近藤愛子、福原規子、石澤賢一、一迫玲
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] The efficacy of consolidation radioimmunotherapy in patients with relapsed indolent B cell lymphoma (2013)
  • Author(s): 氷室真仁、福原規子、石澤賢一、一迫玲
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] A Long Term Observation Of Rheumatoid Arthritis Who Developed Methotrexate Related Lymphoproliferative Disorders. (2013)
  • Author(s): 鴨川由紀子、福原規子
  • Organizer: Rheumatology/Association of Rheumatology Health Professionals Annual Meeting
  • Place of Presentation: 米国、サンディエゴ
• [Presentation] A clinicopathological analysis of extranodal NK/T-cell lymphoma in younger adults: MIYAGI study (2012)
  • Author(s): 福原規子、石澤賢一、一迫玲
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都市
• [Presentation] Allogeneic HSCT in adult patients with EBV-associated T/NK-cell LPD, ENKL, and ANKL (2012)
  • Author(s): 大西康、福原規子、石澤賢一、一迫玲
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都市
• [Presentation] Composite 5q- syndrome and acute lymphoblastic leukemia (2012)
  • Author(s): 大橋圭一、福原規子、石澤賢一
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都市
• [Presentation] Successful treatment for MDS developed from MonoMAC syndrome with GATA2 mutation by RIST (2012)
  • Author(s): 小野寺 晃一、福原規子、石澤賢一
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都市
• [Presentation] 濾胞性リンパ腫の標準治療とResearch Questions (2012)
  • Author(s): 石澤賢一
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都市
  • Invited
• [Book] リンパ腫アトラス第4版 (2014)
  • Author(s): 一迫玲、福原規子 森 茂郎 他
  • Total Pages: 407
  • Publisher: 文光堂
• [Book] EBM 血液疾患の治療 2015-2016 (2014)
  • Author(s): 石澤賢一、金倉謙 他
  • Total Pages: 556
  • Publisher: 中外医学社
• [Book] リンパ腫・骨髄腫の最新療法 (2014)
  • Author(s): 石澤賢一、金倉謙 他
  • Total Pages: 344
  • Publisher: 中山書店